Vitamin detector quality control product composition and application thereof

A vitamin and composition technology, which is applied in the field of quality control of vitamin inspection items, can solve problems such as high maintenance costs, high technical requirements, and complex structures, and achieve low detection costs, good signal reproducibility, and stable chemical properties.

Pending Publication Date: 2020-11-06
中芯维康医疗科技(重庆)有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, it is particularly important to simultaneously determine the content of multiple vitamins. High performance liquid chromatography (HPLC) and liquid chromatography-tandem mass spectrometry (LC-MS / MS) can be used to simultaneously determine multiple vitamins. However, due to factors such as expensive instruments, high maintenance costs, complex structures and high technical requirements for operators, this method is limited in the popularization of this method in clinical vitamin monitoring.

Method used

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  • Vitamin detector quality control product composition and application thereof
  • Vitamin detector quality control product composition and application thereof
  • Vitamin detector quality control product composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 vitamin detector quality control product composition

[0024] Ferrocene: 0.1μmol / L—1000μmol / L;

[0025] Potassium hexafluorophosphate: 0.1μmol / L-0.0001μmol / L or tetrabutylamine hexafluorophosphate 0.1μmol / L-0.0001μmol / L or sodium hexafluorophosphate;

[0026] Organic solvents: ethanol or ether or methanol.

Embodiment 2

[0027] Embodiment 2 Imprecision measurement

[0028] The vitamin detector quality control product prepared by the vitamin detector quality control product composition of Example 1 was continuously detected 10 times by the vitamin detector quality control product, high school and low three concentration levels, and the average value, standard deviation and variation were calculated respectively. Coefficient, where (the concentration range of the quality control product at the high concentration level is 80-105 μmol / L, the concentration range of the quality control product at the medium concentration level is: 40-75 μmol / L, and the concentration range of the quality control product at the low concentration level is: 1-105 μmol / L. 35μmol / L). Day-to-day imprecision determination: the quality control products of three concentrations were measured once a day for 20 consecutive days, and the mean value, standard deviation and coefficient of variation were calculated.

[0029] Vitami...

Embodiment 3

[0048] Embodiment 3 stability test

[0049] The quality control products were measured once every working day, and the measurement was carried out continuously for 6 months, and the average value and standard deviation of each month were calculated respectively. The results are shown in Table 4.

[0050] Table 4 Stability Test

[0051]

[0052] To sum up, the different indicators detected all meet the requirements of quality control products, therefore, the scheme of the present invention is completely feasible.

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Abstract

The invention belongs to the field of vitamin inspection project quality control, and particularly relates to a vitamin detector quality control product composition and application thereof. The vitamin detector quality control product is composed of the following components: ferrocene, a salt solution and an organic solvent. The vitamin detector quality control product composition and the qualitycontrol product provided by the invention are stable in chemical property, simple and rapid to operate, small in repeated detection variability, high in accuracy and stability and low in detection cost, the effective period of the quality control product is as long as 12 months, accurate calibration of a vitamin detector is facilitated, and the stability and reliability of detection data are guaranteed.

Description

technical field [0001] The invention belongs to the field of quality control of vitamin inspection items, and in particular relates to a vitamin detector quality control product composition and an application thereof. Background technique [0002] The human body has very little demand for vitamins. Long-term deficiency of primary or secondary vitamins will lead to physiological dysfunction of the human body and induce various diseases; on the contrary, excessive intake can easily cause overload accumulation and even poisoning. Vitamin content in the body is an effective indicator of nutritional status, and vitamin intake is particularly important for pregnant women, infants and young children. As a means of evaluating rational drug use, vitamin monitoring can improve the safety and effectiveness of vitamin use and realize the individualization of vitamin treatment, which has gradually been valued by clinicians. In routine clinical testing, due to the wide range of vitamin c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/416G01N27/30G01N27/327G01N27/48
CPCG01N27/4163G01N27/308G01N27/3277G01N27/48
Inventor 谢静陈星云许佳王培勇廖彦剑
Owner 中芯维康医疗科技(重庆)有限责任公司
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