Tumor precise and personalized drug treatment method and application

Abstract

The invention relates to a tumor precise and personalized drug treatment method and application, in particular to a method for researching tumors, evaluating the drug effect of an anti-tumor drug, testing the drug effect sensitivity of the anti-tumor drug and screening an anti-tumor treatment scheme by culturing tumor tissues of a patient in vitro. Proper primary tumor samples are selected and cultured in a microenvironment simulating growth of in-vivo sample tumors, so that drug testing can be performed quickly. According to the method, the problems of long time consumption and poor data correlation of tumor personalized treatment scheme screening and antitumor drug evaluation are solved, the in-vivo real environment is better met under the hypoxic culture condition, meanwhile, the used tumor tissue is not digested and dispersed in vitro, the components and characters of the tumor tissue are reserved, and the efficacy of the tumor tissue is ensured. In addition, the consumption of samples and reagents is remarkably reduced, a plurality of experiment related parameters can be obtained at the same time at a time, and expected data can be obtained within 5 days.

Description

Technical field [0001] The present invention relates to the technical field of precision treatment, in particular to a method for culturing tumor models in vitro and using the tumor models to study tumors, evaluate the efficacy of anti-tumor drugs, test the sensitivity of anti-tumor drugs, and screen anti-tumor treatment plans . Background technique [0002] At present, for most different patients suffering from the same disease, the treatment method is to use the same medicine and standard dosage, but in fact, different patients have great differences in the treatment effects and adverse reactions. Sometimes this difference can even be fatal. . Commonly used anti-tumor chemotherapy drugs are less than 70% effective in treating patients, and about 20%-35% of patients have received inappropriate drug treatment. If tumor treatment can treat the same disease with different treatments, different from person to person, and implement individualized treatment, it will greatly improve ...

AI Technical Summary

Problems solved by technology

It also solves the problems of traditional culture methods such as long time-consuming, easy contamination of samples, and low sensitivity, and provides the possibility for the development of drug sensitivity experiments for clinical tumor unidirectional drug use and combined drug use.

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