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Application of Prunella vulgaris in combination with antibiotics in the preparation of anti-multidrug-resistant Staphylococcus aureus drugs

A technology of staphylococcus and Prunella vulgaris, which is applied in the direction of antibacterial drugs, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve obvious synergistic effects and reduce dosage

Active Publication Date: 2022-03-01
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the use of these synthetic compounds to control food spoilage and pathogenic bacteria is highly controversial due to reports that they can cause respiratory illness or other health problems

Method used

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  • Application of Prunella vulgaris in combination with antibiotics in the preparation of anti-multidrug-resistant Staphylococcus aureus drugs
  • Application of Prunella vulgaris in combination with antibiotics in the preparation of anti-multidrug-resistant Staphylococcus aureus drugs
  • Application of Prunella vulgaris in combination with antibiotics in the preparation of anti-multidrug-resistant Staphylococcus aureus drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] After Prunella vulgaris was crushed, distilled water was added at a material-to-liquid ratio of 1:10, placed on a magnetic stirrer and stirred at room temperature for 2 hours, then stirred at 100°C for 2 hours, centrifuged at 10,000×g for 40 minutes, and the supernatant was filtered through filter paper to obtain The supernatant was concentrated by rotary evaporation and then vacuum-concentrated and dried to obtain the Prunella vulgaris extract.

[0026] The aforementioned Prunella vulgaris extract and erythromycin are used in combination in a weight ratio of 1.25:0.064 as an anti-multidrug-resistant Staphylococcus aureus drug.

Embodiment 2

[0028] The Prunella vulgaris extract obtained in Example 1 was mixed with erythromycin at a weight ratio of 1:0.070 to make a powder as an anti-multidrug-resistant Staphylococcus aureus drug.

Embodiment 3

[0030] The Prunella vulgaris extract obtained in Example 1 was mixed with penicillin at a weight ratio of 1:0.020, and corresponding pharmaceutical excipients were added to make tablets, which were used as anti-multidrug-resistant Staphylococcus aureus drugs.

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Abstract

The invention discloses the application of Prunella vulgaris combined with antibiotics in the preparation of anti-multidrug-resistant Staphylococcus aureus medicaments. The present invention can play a significant synergistic effect by using Prunella vulgaris in combination with antibiotics, reduces the dosage of antibiotics, reduces the minimum inhibitory concentration (MIC) of erythromycin to 1 / 2 of that used alone, and the MIC of penicillin can be reduced to 1 / 4 of the drug used alone can effectively play a combined anti-multidrug-resistant Staphylococcus aureus effect.

Description

technical field [0001] The invention relates to the application field of traditional Chinese medicine, in particular to a pharmaceutical composition for resisting drug-resistant bacteria. Background technique [0002] Foodborne illness caused by consumption of food or beverages contaminated with pathogenic microorganisms is one of the major health challenges facing the world. The survival of microorganisms in food is an important issue, which can cause food spoilage and deterioration of quality, leading to infection and disease. WHO's first global estimate of foodborne disease finds almost 1 in 10 people fall ill each year from eating contaminated food, killing 420,000 people, with children under five at particularly high risk , 125,000 children die each year from foodborne illnesses. Staphylococcus aureus is one of the most common food-related pathogens, invading the human body and causing skin infections, food poisoning and other diseases. [0003] Multidrug-resistant S...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/43A61K36/536A61P31/04A61K31/7048
CPCA61K36/536A61K31/7048A61K31/43A61P31/04A61K2300/00
Inventor 杨杏芬黎姿茵司徒琛池慧钦王延
Owner SOUTHERN MEDICAL UNIVERSITY
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