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Visual radioactive carbon microsphere as well as preparation method and application thereof

A technology of radiocarbon and carbon microspheres, applied in the field of medicine, can solve the problems of inconsistent distribution and metabolic behavior of contrast agents and radioactive microspheres, inconvenient clinical use, and inability to accurately monitor the location of radioactive microspheres for a long time, and achieve visualization. Therapeutic, high-efficiency loading effect

Active Publication Date: 2020-11-13
CHENGDU NEW RADIOMEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these contrast techniques can only be used for short-term imaging, and the contrast agent and the therapeutic drug are two different drugs or individuals, so there are at least two problems: 1. It is necessary to give contrast agent alone to achieve imaging, which brings great inconvenience to clinical use. Big inconvenience; 2. Inconsistent distribution and metabolic behavior of contrast agents and radioactive microspheres in the body cannot accurately monitor the position of radioactive microspheres for a long time, etc.

Method used

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  • Visual radioactive carbon microsphere as well as preparation method and application thereof
  • Visual radioactive carbon microsphere as well as preparation method and application thereof
  • Visual radioactive carbon microsphere as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] A visible suspension of radioactive carbon microspheres, each 1ml of the solution contains: carbon microspheres 10-500mg, therapeutic radionuclide activity 5-500mCi, radioactive zirconium[ 89 Zr] activity 0.1-100mCi, small organic molecules 0-100mg, first solution 0.1-1.0ml.

[0064] Specifically, the carbon microspheres are spherical or non-spherical carbon materials rich in micropores and mesopores prepared by any method, with a diameter of 0.05-1000 μm, preferably 20-60 μm. The visualized carbon microsphere products prepared by carbon microspheres with different particle sizes can be used for visual treatment of different solid tumor lesions due to different administration methods and different distributions in tissues, organs and lesions.

[0065] Specifically, the small organic molecule is 5-sulfosalicylic acid, 5-nitrosalicylic acid or a small molecule with a similar structure obtained through simple chemical modification.

[0066] Specifically, the first solutio...

Embodiment 2

[0069] A preparation method of visualized radiocarbon microsphere suspension, the method comprises the following steps:

[0070] Mix the radionuclide solution for treatment with the small molecule aqueous solution and let it stand for 2min-20min;

[0071] Adsorb the therapeutic radionuclide in the above mixed solution with carbon microspheres and let stand for 2min-20min;

[0072] Mix and react the carbon microspheres after absorbing therapeutic radionuclides with sodium phosphate solution, let stand for 2min-20min, wash and separate the solid and liquid to obtain the first intermediate;

[0073] Mix the first intermediate with the organic small molecule aqueous solution with a pH value of 1-14, preferably 3.5-6.5, and then let it stand for 2min-20min to obtain the first intermediate solution;

[0074] Adding the radioactive zirconium with a pH value of 1-14, preferably 3.5-7.5, in the first intermediate solution [ 89 Zr] ion solution, after mixing evenly, let it stand for 2...

Embodiment 3

[0077] A preparation method of visualized radiocarbon microsphere suspension, the method comprises the following steps:

[0078] Use carbon microspheres to adsorb organic small molecules in an organic small molecule aqueous solution with a pH value of 1-14, preferably 3.5-6.5;

[0079] Adsorption of radioactive zirconium by the above-mentioned carbon microspheres after adsorption of small organic molecules[ 89 Zr], obtain the third intermediate;

[0080] Using the third intermediate to adsorb the therapeutic radionuclide in the mixed solution of the therapeutic radionuclide and the organic small molecule aqueous solution;

[0081] Mixing and reacting the third intermediate after absorbing therapeutic radionuclides with sodium phosphate solution, washing and separating solid and liquid to obtain the fourth intermediate; and

[0082] Add the first solution to the fourth intermediate, mix evenly, and carry out moist heat sterilization after sub-packaging. The sterilization cond...

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Abstract

The invention belongs to the technical field of medicines, and discloses a visual radioactive carbon microsphere suspension as well as a preparation method and application thereof. Every 1 ml of the visual radioactive carbon microsphere suspension comprises 10-500 mg of carbon microspheres, 5-500 mCi of radionuclide activity for treatment, 0.1-100 mCi of radionuclide activity for imaging, 0-100 mgof organic small molecules and 0.1-1.0 ml of a first solution. The preparation method mainly comprises the following step of adsorbing small organic molecules, radionuclide for treatment and zirconium [<89>Zr] for imaging by using the carbon microspheres; the visual radioactive carbon microsphere suspension disclosed by the invention can simultaneously realize local radioactive treatment and real-time development of solid tumor lesions to realize visualized treatment of tumors, and a novel radioactive carbon microsphere product integrating diagnosis and treatment is provided.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a suspension of visualized radioactive carbon microspheres and its preparation method and application. Background technique [0002] In recent years, local minimally invasive radiotherapy has played an increasingly important role in clinical treatment, especially in the treatment of unresectable liver cancer, prostate cancer, kidney cancer and other solid tumors. [0003] At present, the radioactive microsphere products used clinically for local minimally invasive radiotherapy for advanced liver cancer mainly include yttrium [ 90 Y] resin microspheres SIR-Spheres® (Sirtex Medical Limited, Australia) and yttrium [ 90 Y] Glass microspheres TheraSphere® (BTG, UK). Due to radioactive yttrium [ 90 Y] nuclide is a pure β nuclide, which can only produce gamma rays for imaging through bremsstrahlung, so it can only provide Blurred images (such as figure 1 As shown), the in vivo dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/12A61K51/04A61P35/00
CPCA61K51/1217A61K51/0402A61P35/00A61K51/1251A61K2123/00
Inventor 赵小生张钧张驰翔路静刘强强罗显进赵世强马文亮葛强蔡继鸣
Owner CHENGDU NEW RADIOMEDICINE TECH CO LTD