Cyclodextrin hyperbranched derivative and preparation method thereof

Abstract

The invention discloses a cyclodextrin hyperbranched derivative and a preparation method thereof. The preparation method comprises the steps: with cyclodextrin as a starting raw material, carrying outring-opening reaction on glycidyl under the alkaline condition so as to prepare cyclodextrin grafted hyperbranched polyglycerol; then reacting the cyclodextrin grafted hyperbranched polyglycerol withepoxy chloropropane to obtain cyclodextrin grafted hyperbranched polyglycerol glycidyl ether; and finally, grafting epoxy groups on hyperbranched polyglycerol glycidyl ether molecules by utilizing molecular ring-opening cyclodextrin with primary amine or secondary amine groups to obtain the cyclodextrin hyperbranched derivative. According to the preparation method, epoxy groups are modified on cyclodextrin hyperbranched polyglycerol, and then amino ring-opening epoxy groups on micromolecular amine are used for performing micromolecular amine modification, so that the cationic property of amino is retained; meanwhile, hydroxyl is generated by epoxy ring opening, so that the hydrophilicity of the final cyclodextrin hyperbranched derivative is ensured.

Description

technical field [0001] The invention relates to a cyclodextrin derivative and a preparation method thereof, in particular to a cyclodextrin hyperbranched derivative and a preparation method thereof. Background technique [0002] Cyclodextrin (CD) is a general term for cyclic oligosaccharides formed by 6 or more glucopyranose molecules forming a ring through α-1,4-glycosidic bonds, which can be acted on by cyclodextrin glucosyltransferase produced by starch. The most common are α-CD, β-CD, and γ-CD, which consist of 6, 7, and 8 glucopyranose units, respectively. Cyclodextrin is widely used in food, medicine, agriculture, cosmetics and other fields due to its unique truncated cone structure, which is hydrophilic on the outside and hydrophobic on the inside, and can form clathrates with specific molecules. [0003] There are strong hydrogen bonds between the molecules of CD, which limits the water solubility of cyclodextrin, and the ability to include and bind guest molecules...

AI Technical Summary

Problems solved by technology

The β-cyclodextrin derivatives constructed by this method, on the one hand, have a relatively limited degree of hyperbranching, resulting in a limited number of hydroxyl values ​​that can be linked with small molecular amines; on the other hand, β-cyclodextrin hyperbranched Molecular amines are linked by urethane bonds. Each small molecular amine linked will consume one hydroxyl group, and small molecular amines will also consume one amino group.

This will inevitably lead to the loss of cationicity of β-cyclodextrin derivatives, and insufficient hydrophilicity, especially under high pH conditions.

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