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Synthesis process of high-quality span-80

A synthesis process and technology of Span, which is applied in the field of synthesis process of high-quality Span 80, can solve the problems of difficult application, low solubility, toxicity, etc., and achieve the effect of simplified process and good quality

Pending Publication Date: 2020-11-20
IANGSU COLLEGE OF ENG & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the relatively small solubility of sorbitol in oleic acid, most of the reactions have adopted organic solvents, and most of the organic solvents have certain toxicity, which brings difficulties to the application.

Method used

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  • Synthesis process of high-quality span-80
  • Synthesis process of high-quality span-80
  • Synthesis process of high-quality span-80

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0029] A kind of synthetic technique of high-quality Span 80, comprises the steps:

[0030] (1) Weigh 10g of anhydrous sorbitol powder and 0.1g of etherification catalyst AlCl 3 Carry out the etherification reaction at 150°C under vacuum (vacuum degree not less than 0.096MPa) and nitrogen protection, and take samples to measure the hydroxyl value after reacting for 120 minutes;

[0031] (2) When the hydroxyl value is at 1300-1400mgKOH / g, add 25g oleic acid (the molar ratio of anhydrous sorbitol to oleic acid is 1:1.61) and 0.2g esterification catalyst Z 2 (esterification catalyst Z 2 by NaOH and Na 2 CO 3 composition, the mass ratio of the two is 5:2) the esterification reaction is also carried out at 200°C under vacuum and nitrogen protection, and the acid value is measured by sampling after 150 minutes of reaction;

[0032] (3) When the acid value is less than or equal to 7mgKOH / g, stop the reaction, then cool down with cooling water, and stop vacuuming when the temperat...

specific Embodiment 2

[0039] A kind of synthetic technique of high-quality Span 80, comprises the steps:

[0040] (1) Weigh 10g of anhydrous sorbitol powder and 0.12g of etherification catalyst AlCl 3 Carry out the etherification reaction at 150°C under vacuum (vacuum degree not less than 0.096MPa) and nitrogen protection, and take samples to measure the hydroxyl value after reacting for 90 minutes;

[0041] (2) When the hydroxyl value is at 1300-1400mgKOH / g, add 25g oleic acid (the molar ratio of anhydrous sorbitol to oleic acid is 1:1.61) and 0.24g esterification catalyst Z 2 (esterification catalyst Z 2 by NaOH and Na 2 CO 3 composition, the mass ratio of the two is 5:2) the esterification reaction is also carried out at 200°C under vacuum and nitrogen protection, and the acid value is measured by sampling after 150 minutes of reaction;

[0042] (3) When the acid value is less than or equal to 7mgKOH / g, stop the reaction, then cool down with cooling water, and stop vacuuming when the tempera...

specific Embodiment 3

[0050] A kind of synthetic technique of high-quality Span 80, comprises the steps:

[0051] (1) Weigh 10g anhydrous sorbitol powder and 0.15g etherification catalyst ZnCl 2 Carry out the etherification reaction at 150°C under vacuum (vacuum degree not less than 0.096MPa) and nitrogen protection, and take samples to measure the hydroxyl value after reacting for 150 minutes;

[0052] (2) When the hydroxyl value is at 1300-1400mgKOH / g, add 25g oleic acid (the molar ratio of anhydrous sorbitol to oleic acid is 1:1.61) and 0.3g esterification catalyst Z 2 (esterification catalyst Z 2 by NaOH and Na 2 CO 3 composition, the mass ratio of the two is 5:2) the esterification reaction is also carried out at 200°C under vacuum and nitrogen protection, and the acid value is measured by sampling after 150 minutes of reaction;

[0053] (3) When the acid value is less than or equal to 7mgKOH / g, stop the reaction, then cool down with cooling water, and stop vacuuming when the temperature i...

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Abstract

The invention discloses a synthesis process of high-quality span-80. The process comprises the following steps: weighing a certain amount of anhydrous sorbitol powder and a certain amount of etherification catalyst, carrying out etherification dehydration reaction at a certain temperature under the conditions of vacuum pumping and nitrogen protection, and after reacting for a period of time, carrying out sampling and measuring the hydroxyl value; when the hydroxyl value is reduced to a specified range, adding oleic acid having a certain ratio with anhydrous sorbitol and a certain amount of esterification catalyst into the reaction material and carrying out esterification reaction at a certain temperature under the conditions of vacuum pumping and nitrogen protection, and carrying out sampling to measure the acid value after the reaction is carried out for a period of time; when the acid value is reduced to a certain value, stopping the reaction, then introducing cooling water for cooling, and when the temperature is reduced to a certain temperature, stopping vacuumizing; and continuously cooling to room temperature, standing for a period of time, and carrying out reduced pressure suction filtration to obtain a filtrate, namely the product. The product synthesized by the method has the advantages of light color, few byproducts, good transparency and fluidity, reasonable distribution of internal esters, no need of decolorization treatment and the like.

Description

technical field [0001] The invention belongs to the field of fine chemicals, and in particular relates to a synthesis process of high-quality Span 80. Background technique [0002] Span 80, also known as Span-80, has a chemical name of sorbitan monooleate, which is formed by esterifying sorbitol with oleic acid after dehydration, and its hydrophilic-lipophilic balance value (HLB value) is 4.3 , can be miscible with oil to become water-in-oil (W / O) emulsifier. It is a non-ionic surfactant with excellent emulsifying, dispersing, foaming, and wetting properties. In addition to being used as a food additive, it can be used as a solubilizer in the pharmaceutical industry. At present, although there are many domestic manufacturers, there are quality problems such as poor coloring, uneven reaction products, many sediments, and high freezing points to varying degrees. The imported Span 80 is expensive, which also affects economic benefits. [0003] According to domestic and fore...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/20
CPCC07D307/20
Inventor 张民
Owner IANGSU COLLEGE OF ENG & TECH
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