Chitosan-based antibacterial wound dressing with excellent mechanical properties and antibacterial properties

A wound dressing, chitosan technology, applied in medical science, bandages, etc., can solve problems affecting application effect, complex processing technology and synthesis technology, biocompatibility, etc., achieve good skin adhesion, help On the mechanical properties, the effect of reducing the crosslinking density

Active Publication Date: 2020-11-24
HUNAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above methods still require more complex processing technology and synthesis technology, and need to introduce other substances, which will definitely affect the biocompatibility of the membrane itself, and then affect its application effect.

Method used

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  • Chitosan-based antibacterial wound dressing with excellent mechanical properties and antibacterial properties
  • Chitosan-based antibacterial wound dressing with excellent mechanical properties and antibacterial properties
  • Chitosan-based antibacterial wound dressing with excellent mechanical properties and antibacterial properties

Examples

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Effect test

Embodiment 1

[0028] A chitosan-based antibacterial wound dressing with excellent mechanical properties and antibacterial properties, the preparation process of which is as follows:

[0029] (1) Preparation of chitosan heterogeneous solution: Lithium hydroxide, potassium hydroxide, urea, and deionized water were prepared in a certain mass ratio to form a uniform lye, and a certain mass of chitosan powder was weighed and added at room temperature Place in the lye and stir for 2.5h until fully swollen and then freeze at -30°C for 6h, then thaw and stir at 25°C, and form a heterogeneous solution I after standing for 6 hours; wherein the mass fraction of chitosan 5%; the mass ratio of lithium hydroxide, potassium hydroxide, urea, and deionized water in the lye is 5:7:8:81;

[0030] (2) Preparation of composite solution: Add aldehyde-terminated four-arm polyethylene glycol, amino-terminated four-arm polyethylene glycol, and polyethylene glycol-terminated eight-arm cage silsesquioxane to heteroge...

Embodiment 2

[0040] A chitosan-based antibacterial wound dressing with excellent mechanical properties and antibacterial properties, the preparation process of which is as follows:

[0041] (1) Preparation of chitosan heterogeneous solution: Lithium hydroxide, potassium hydroxide, urea, and deionized water were prepared in a certain mass ratio to form a uniform lye, and a certain mass of chitosan powder was weighed and added at room temperature Place in the lye and stir for 2.4h until fully swollen and then freeze at -30°C for 6.5h, then thaw and stir at 24°C, and form a heterogeneous solution I after standing for 7 hours; wherein the mass of chitosan The fraction is 4.5%; the mass ratio of lithium hydroxide, potassium hydroxide, urea, and deionized water in the lye is 4.5:7.5:8.5:82;

[0042] (2) Preparation of composite solution: Add aldehyde-terminated four-arm polyethylene glycol, amino-terminated four-arm polyethylene glycol, and polyethylene glycol-terminated eight-arm cage silsesqui...

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Abstract

The invention relates to a chitosan-based antibacterial wound dressing with excellent mechanical properties and antibacterial properties. The chitosan-based antibacterial wound dressing is prepared through firstly, dissolving chitosan in an alkaline solution so as to achieve a partial-dissolved partial-self-assembled-sphere heterogeneous solution, then, adding a cross-linker aldehyde-group-terminated four-arm polyethylene glycol and additives, i.e., amino-terminated four-arm polyethylene glycol and polyethylene-glycol-group-terminated eight-arm cage-shaped silsesquioxane, carrying out cross-linking forming, then, carrying out soaking treatment by employing an aqueous solution of ammonium sulfate, thereby obtaining a final product. The film has good biocompatibility, antibacterial property,skin adhesivity, absorption swellability and water retention property, also has good mechanical properties and can independently serve as an antibacterial wound dressing.

Description

technical field [0001] The invention relates to a chitosan-based hydrogel antibacterial wound dressing, in particular to a chitosan-based antibacterial wound dressing with excellent mechanical properties, biocompatibility and antibacterial properties. Background technique [0002] The surface of open wounds in the human body is prone to infection. How to effectively reduce the probability of wound infection and promote wound recovery and tissue refunctionalization is a hotspot and difficulty that needs to be solved urgently in the medical field. Traditional dressings such as gauze and bandages are composed of dry fabrics that absorb permeation The degree of fluid output is limited, and the newly formed tissue is easily damaged during removal, causing secondary injury. Hydrogels are a good form of choice for wound dressings due to their swelling, water-retaining, and easy-to-remove properties. Chitosan itself has good antibacterial and cytocompatibility, and is often used ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08J5/18C08J7/02C08J3/26C08L5/08C08L71/02C08L83/06
CPCA61L26/0052A61L26/008A61L26/0066C08J5/18C08J7/02C08J3/246C08J2305/08C08J2471/02C08J2483/06A61L2300/232A61L2300/404C08L5/08C08L71/02C08L83/06
Inventor 陈一卢嘉威刘文勇
Owner HUNAN UNIV OF TECH
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