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Preparation method of hawthorn leaf aqueous extract

A technology of hawthorn extract and hawthorn leaf, which is applied in the field of preparation of hawthorn leaf water extract, can solve the problem of losing the effective components of hawthorn leaf, achieve the effect of improving the purification rate, promoting dissolution, and improving the purification rate

Inactive Publication Date: 2020-11-27
江西纳弗堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the main components in hawthorn leaves are flavonoids, organic acid compounds, saponins, and polysaccharides. Except for flavonoids, which are easily soluble in alcohol, most of the other components are more soluble in water. Medicinal ingredients in hawthorn leaves

Method used

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  • Preparation method of hawthorn leaf aqueous extract
  • Preparation method of hawthorn leaf aqueous extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 100g hawthorn leaves are pulverized, water is added, and tetrabutyl phosphate alanine ionic liquid is added to obtain a mixed material liquid, the amount of water added is 7 times of the mass of hawthorn leaves; the addition of tetrabutyl phosphate alanine ionic liquid The amount is 0.7 times of the mass of hawthorn leaves; air is blown into the mixture liquid, and the air velocity is 30ml / min; the mixture liquid is heated by microwave for 60s in an ultrasonic environment, and heated once every 10s; ultrasonic power is 200W, and ultrasonic temperature is 40 °C; first separate the foam on the mixed material liquid, then centrifuge the mixed material liquid after removing the foam, take the supernatant and concentrate it to obtain a primary extract;

[0026] Add the primary extract to the propanol-ammonium sulfate dual-phase system, the mass fraction of propanol in the propanol-ammonium sulfate dual-phase system is 30%, and the mass fraction of ammonium sulfate is 10%;

...

Embodiment 2

[0032] 100g hawthorn leaves are pulverized, water is added, and tetrabutyl phosphate alanine ionic liquid is added to obtain a mixed material liquid, the amount of water added is 8 times of the mass of hawthorn leaves; the addition of tetrabutyl phosphate alanine ionic liquid The amount is 0.9 times of the quality of hawthorn leaves; air is blown into the mixture liquid, and the airflow speed is 120ml / min; the mixture liquid is heated by microwave for 80s in an ultrasonic environment, and heated once every 20s; the ultrasonic power is 300W, and the ultrasonic temperature is 50 °C; first separate the foam on the mixed material liquid, then centrifuge the mixed material liquid after removing the foam, take the supernatant and concentrate it to obtain a primary extract;

[0033] Add the primary extract to the propanol-ammonium sulfate two-phase system, the mass fraction of propanol in the propanol-ammonium sulfate two-phase system is 40%, and the mass fraction of ammonium sulfate ...

Embodiment 3

[0039] 100g hawthorn leaves are pulverized, water is added, and tetrabutyl phosphate alanine ionic liquid is added to obtain a mixed material liquid, the amount of water added is 10 times of the mass of hawthorn leaves; the addition of tetrabutyl phosphate alanine ionic liquid The amount is 1.5 times of the mass of hawthorn leaves; air is blown into the mixture liquid, and the air velocity is 200ml / min; the mixture liquid is heated by microwave for 100s in an ultrasonic environment, and heated once every 25s; the ultrasonic power is 400W, and the ultrasonic temperature is 80 °C; first separate the foam on the mixed material liquid, then centrifuge the mixed material liquid after removing the foam, take the supernatant and concentrate it to obtain a primary extract;

[0040] Add the primary extract to the propanol-ammonium sulfate dual-phase system, the mass fraction of propanol in the propanol-ammonium sulfate dual-phase system is 60%, and the mass fraction of ammonium sulfate ...

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Abstract

The invention discloses a preparation method of a hawthorn leaf aqueous extract, and belongs to the field of traditional Chinese medicine and pharmacy. A hawthorn extract comprises flavone and polysaccharide. The preparation method comprises the following steps of crushing hawthorn leaves, adding water, adding ionic liquid, blowing air into mixed liquor, at the same time, performing ultrasonic / microwave cooperative treatment, separating foams from the mixed liquor, then performing centrifugal separation on the mixed liquor after foam removal, taking supernatant, and performing concentration toobtain a primary extracting solution; adding a propanol-ammonium sulfate biphase system to the primary extracting solution, wherein the propanol-ammonium sulfate biphase system comprises a propanol top phase and an ammonium sulfate bottom phase, performing stirring to enable flavone in the hawthorn aqueous extract to enter the propanol top phase and polysaccharide in the hawthorn aqueous extractto enter the ammonium sulfate bottom phase, performing standing, and performing separation on the two phases; and step III, respectively performing extracting on a propanol phase containing flavone and an ammonium sulfate phase containing polysaccharide so as to obtain the flavone and the polysaccharide. The hawthorn leaf aqueous extract disclosed by the invention is high in contents of the flavone and the polysaccharide.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a method for preparing an aqueous extract of hawthorn leaves. Background technique [0002] Hawthorn leaves are the dried leaves of the Rosaceae plant Shanlihong or Hawthorn. Hawthorn leaves are sour in taste and calm in nature, and belong to the liver meridian. They have the effects of promoting blood circulation, removing blood stasis, regulating qi and dredging channels. Among them, the main components in hawthorn leaves are flavonoids, organic acid compounds, saponins, and polysaccharides. Except for flavonoids, which are easily soluble in alcohol, most of the other components are more soluble in water. Medicinal ingredients in hawthorn leaves. Contents of the invention [0003] The object of the present invention is to at least solve one of the technical problems existing in the prior art, and provide a preparation method of the water extract of hawthorn leave...

Claims

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Application Information

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IPC IPC(8): A61K36/734A61P7/00A61P9/00A61P9/06A61P25/28A61P1/08A61P27/16C08B37/00A61K127/00
CPCA61K36/734A61K2236/333A61K2236/51A61K2236/53A61P1/08A61P7/00A61P9/00A61P9/06A61P25/28A61P27/16C08B37/0003
Inventor 宋细忠李小丽陈述耀王德红谭群习梅兰黄成尹炜简勇学钱丽梅郭磊夫
Owner 江西纳弗堂制药有限公司
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