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Composition, preparation method of pseudo-ginseng extract, and application of pseudo-ginseng extract

A technology of composition and extract, which is applied in the field of medicine to achieve the effect of reducing blood viscosity, good drug effect and improving therapeutic effect

Pending Publication Date: 2020-12-04
CHENGDU HUASUN GRP INC LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, it is difficult for the pharmaceutical preparations based on this notoginseng triol saponin to exert better targeted drug effects for specific diseases.

Method used

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  • Composition, preparation method of pseudo-ginseng extract, and application of pseudo-ginseng extract
  • Composition, preparation method of pseudo-ginseng extract, and application of pseudo-ginseng extract
  • Composition, preparation method of pseudo-ginseng extract, and application of pseudo-ginseng extract

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preparation example Construction

[0035] The invention discloses a composition, a preparation method of the Panax notoginseng extract and the application of the Panax notoginseng extract, and those skilled in the art can learn from the content of this article and appropriately improve the process parameters to achieve. It should be particularly pointed out that all similar substitutions and modifications are obvious to those skilled in the art, and they are deemed to be included in the present invention. The method and application of the present invention have been described through the preferred preparation examples, and it is obvious that relevant persons can make changes or appropriate changes and combinations of the methods and applications described herein without departing from the content, spirit and scope of the present invention to achieve and application of the technology of the present invention.

[0036] The composition provided by the present invention, the preparation method of the Panax notogins...

preparation Embodiment 1

[0039] A preparation method of notoginseng saponin, comprising the following steps:

[0040] S1, take 150kg of Panax notoginseng (origin: Wenshan, Yunnan Province) for cleaning and impurity removal, add 200kg of saturated calcium hydroxide aqueous solution to soak for 1.5h at 35°C and take out, then rinse the Panax notoginseng with clear sterile water , and then soaking Panax notoginseng with carbendazim for 25min at room temperature and taking it out to obtain treated Panax notoginseng;

[0041]S2, pulverize the Panax notoginseng treated in step S1 with a universal pulverizer (purchased from Shanghai Tianhe Pharmaceutical Machinery Factory, model GF-300) to obtain Panax notoginseng powder, and the particle size of Panax notoginseng powder is 2~10 meshes;

[0042] S3, adopt the ethanol of 62wt% to soak the Panax notoginseng powder in step S2 for 19h and then fill the Panax notoginseng powder into the percolation equipment to obtain the Panax notoginseng powder to be percolated...

preparation Embodiment 2

[0045] The difference from Preparation Example 1 is that in step S3, the volume ratio of ethanol to the Panax notoginseng powder is 5:1. In step S4, ethanol with a concentration of 65wt% is added, and the volume ratio of ethanol to the Panax notoginseng powder is 5:1. The weight of the obtained PTS was 7.1 kg.

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Abstract

The invention relates to the field of medicines, in particular to a composition, a preparation method of a pseudo-ginseng extract, and an application of the pseudo-ginseng extract. The composition comprises notoginsenoside R1, ginsenoside Rg1 and ginsenoside Re, wherein the weight ratio of notoginsenoside R1 to ginsenoside Rg1 to ginsenoside Re is (2.05-2.5):(7.5-9.4):1. The invention also provides an application of the composition in the preparation of medicines for preventing and / or treating cardiovascular and cerebrovascular diseases. The preparation method of the pseudo-ginseng extract comprises the following steps: taking pseudo-ginseng, performing cleaning and impurity removal, then performing pretreatment, crushing, mixing with ethanol for soaking and percolating, collecting a percolation solution, and concentrating and filtering to obtain the pseudo-ginseng extract. The composition provided by the invention can effectively treat cardiovascular and cerebrovascular diseases, andcan generate better treatment effects compared with an existing Panaxtriol saponin composition.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a composition, a preparation method of a Panax notoginseng extract and an application of the Panax notoginseng extract. Background technique [0002] Panax notoginseng (Burk.) F.H.chen, also known as Panax notoginseng, Panax notoginseng, Panax notoginseng, mountain lacquer, Jinbuhuan or blood ginseng, etc., is a perennial herb of the Araliaceae (Araliaceae) genus Panax Linn , because it is dug three to seven years after sowing and each plant has three petioles, each petiole has seven leaves, hence the name Panax notoginseng. Its stems, leaves and flowers can be used as medicine, and it is a unique and precious Chinese medicinal material in China. According to relevant literature records, Panax notoginseng has been used for nearly 600 years and cultivated for nearly 500 years. Panax notoginseng is known as "Gold is not exchanged" and "Sacred Grass of the South" because it has been recogni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P9/00A61P9/10
CPCA61K31/704A61P9/00A61P9/10A61K36/258A61K2300/00
Inventor 吴晖晖夏木秀王恒郑洪军王必武徐志毅
Owner CHENGDU HUASUN GRP INC LTD
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