Preparation method of whole ganoderma lucidum spore oil nanoemulsion rich in ganoderic acid

Abstract

The invention discloses a preparation method of whole ganoderma lucidum spore oil nanoemulsion rich in ganoderic acid. The preparation method comprises the following steps of: (1), by taking whole ganoderma lucidum spore powder as a raw material, performing dry pressing one-step granulation, and performing supercritical CO<2> extraction in a supercritical CO<2> extraction kettle so as to obtain light yellow whole ganoderma lucidum spore oil rich in ganoderic acid; and (2), preparing the whole ganoderma lucidum spore oil nanoemulsion from the whole ganoderma lucidum spore oil and an auxiliary agent. The whole ganoderma lucidum spore oil is rich in the effective component ganoderic acid with an anti-tumour effect; and the content of the representative component ganoderic acid B of the ganoderma lucidum spore oil is more than three times of that of pure ganoderma lucidum spore oil. According to the preparation method in the invention, the application resources of ganoderma lucidum and ganoderma lucidum spore powder are expanded; and furthermore, the content of ganoderic acid in the ganoderma lucidum spore oil is greatly increased. The method provided by the invention is simple in technological process, convenient to operate and suitable for industrial production; and the product is stable in quality and convenient in quality control, and can be used for medicines and foods.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a preparation method of whole ganoderma lucidum spore oil nanoemulsion rich in ganoderma acid. Background technique [0002] Ganoderma lucidum has a history of medicinal and edible use in my country for thousands of years. It is a traditional traditional Chinese medicine that strengthens the body and strengthens the body. Class Polyporaceae (Polyporaceae) Ganoderma (Ganoderma) fungus G. lucidum. karst and Zizhi G. japonicum Lloyd. Amino acids, vitamins, alkaloids and inorganic ions. Among them, ganoderma triterpene acids are components with strong physiological activity in ganoderma, and ganoderma acid A is the main representative component of ganoderma triterpene acids in ganoderma. The triterpenoid components of Ganoderma lucidum are poor in water solubility, and because of the tough texture of Ganoderma lucidum, it is difficult to break and chop. Therefore, lipid components...

AI Technical Summary

Problems solved by technology

Chinese patent CN 200410017468.8 discloses a supercritical CO 2 Extraction method, although this method uses the ganoderma fruiting bodies and ganoderma spores that are crushed into particles as raw materials, but in supercritical CO 2 During the extraction, edible ethanol was used as a carrier to participate in the extraction, and the obtained extract was in the form of ointment, which contained not only lipid components, but also water-soluble polysaccharides, which was quite different from the composition of Ganoderma lucidum spore oil, and the oil Difficult to make pastes into nanoemulsions