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Preparation method of whole ganoderma lucidum spore oil nanoemulsion rich in ganoderic acid

A technology of Ganoderma lucidum spore oil and Ganoderma lucidum spore powder, which is applied in the field of medicine, can solve problems such as difficulty in making nanoemulsions, achieve the effects of easy quality control, saving production costs, and avoiding component damage

Inactive Publication Date: 2020-12-08
江苏圣典医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN 200410017468.8 discloses a supercritical CO 2 Extraction method, although this method uses the ganoderma fruiting bodies and ganoderma spores that are crushed into particles as raw materials, but in supercritical CO 2 During the extraction, edible ethanol was used as a carrier to participate in the extraction, and the obtained extract was in the form of ointment, which contained not only lipid components, but also water-soluble polysaccharides, which was quite different from the composition of Ganoderma lucidum spore oil, and the oil Difficult to make pastes into nanoemulsions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1. Determination method of ganoderma acid B in whole ganoderma spore oil or pure ganoderma spore oil

[0064] Whole Ganoderma lucidum spore oil contains a variety of chemical components, among which Ganoderma lucidum triterpene acids (Ganoderma acids) compounds are one of the main active ingredients, which have various pharmacological effects such as anti-tumor, liver protection, detoxification, and anti-aging; Whole Ganoderma lucidum spores The oil contains all the fat-soluble ingredients contained in Ganoderma lucidum and Ganoderma lucidum spores, and there are at least 20 kinds of Ganoderma acid components in the oil. At present, the more accurate determination method of ganoderma acid in ganoderma lucidum spore oil mostly adopts high performance liquid chromatography (HPLC) method.

[0065] Determination of ganoderma acid B in whole ganoderma spore oil or pure ganoderma lucidum spore oil: Determination of chromatographic conditions and system suitability tes...

Embodiment 2

[0070] Embodiment 2. One of preparation method of whole ganoderma lucidum spore oil and nanoemulsion thereof

[0071] Take 3.9 kg of Ganoderma lucidum, pulverize it into 200-mesh superfine powder through a superfine pulverizer, and obtain about 3.6 kg of Ganoderma lucidum superfine powder; take another 3.2 kg of Ganoderma lucidum spore powder, and freeze and ultrafinely break the wall to obtain about 98% of the wall-breaking rate. Broken ganoderma lucidum spore powder is about 3.0kg. Take the obtained Ganoderma lucidum superfine powder and broken Ganoderma lucidum spore powder, add 60g of starch, mix evenly, dry-press the granules directly with a dry-press granulator, the main pressure is 5MPa, and the side pressure is 0.6MPa to make granules of 0.2-0.3cm, and sieve. Sieve the fine powder above 60 mesh, and then granulate the fine powder in the same way. The obtained whole Ganoderma lucidum spore powder particles were placed in a supercritical carbon dioxide extraction kettle...

Embodiment 3

[0078] Embodiment 3. The second preparation method of Ganoderma lucidum spore oil and nanoemulsion thereof

[0079] Take 5.1kg of Ganoderma lucidum, pulverize it into 200 mesh superfine powder through a superfine pulverizer, and obtain about 4.5kg of Ganoderma lucidum superfine powder; take another 3.2kg of Ganoderma lucidum spore powder, and freeze and ultrafinely break the wall to obtain about 98.7% of the wall breaking rate. Broken ganoderma lucidum spore powder is about 3.0kg. Take the obtained Ganoderma lucidum superfine powder and broken Ganoderma lucidum spore powder, add 70g of dextrin, mix evenly, dry-press the granules directly with a dry-press granulator, the main pressure is 5MPa, and the side pressure is 0.5MPa to make granules of 0.2-0.3cm, and sieve , sieve to remove the fine powder above 60 mesh, and then granulate the fine powder by the same method. The obtained whole Ganoderma lucidum spore powder particles were placed in a supercritical carbon dioxide extra...

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Abstract

The invention discloses a preparation method of whole ganoderma lucidum spore oil nanoemulsion rich in ganoderic acid. The preparation method comprises the following steps of: (1), by taking whole ganoderma lucidum spore powder as a raw material, performing dry pressing one-step granulation, and performing supercritical CO<2> extraction in a supercritical CO<2> extraction kettle so as to obtain light yellow whole ganoderma lucidum spore oil rich in ganoderic acid; and (2), preparing the whole ganoderma lucidum spore oil nanoemulsion from the whole ganoderma lucidum spore oil and an auxiliary agent. The whole ganoderma lucidum spore oil is rich in the effective component ganoderic acid with an anti-tumour effect; and the content of the representative component ganoderic acid B of the ganoderma lucidum spore oil is more than three times of that of pure ganoderma lucidum spore oil. According to the preparation method in the invention, the application resources of ganoderma lucidum and ganoderma lucidum spore powder are expanded; and furthermore, the content of ganoderic acid in the ganoderma lucidum spore oil is greatly increased. The method provided by the invention is simple in technological process, convenient to operate and suitable for industrial production; and the product is stable in quality and convenient in quality control, and can be used for medicines and foods.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a preparation method of whole ganoderma lucidum spore oil nanoemulsion rich in ganoderma acid. Background technique [0002] Ganoderma lucidum has a history of medicinal and edible use in my country for thousands of years. It is a traditional traditional Chinese medicine that strengthens the body and strengthens the body. Class Polyporaceae (Polyporaceae) Ganoderma (Ganoderma) fungus G. lucidum. karst and Zizhi G. japonicum Lloyd. Amino acids, vitamins, alkaloids and inorganic ions. Among them, ganoderma triterpene acids are components with strong physiological activity in ganoderma, and ganoderma acid A is the main representative component of ganoderma triterpene acids in ganoderma. The triterpenoid components of Ganoderma lucidum are poor in water solubility, and because of the tough texture of Ganoderma lucidum, it is difficult to break and chop. Therefore, lipid components...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/074A61K9/107A61K47/24A61K47/10A61P35/00B82Y5/00
CPCA61K9/0053A61K9/1075A61K36/074A61K47/10A61K47/24A61K2236/37A61P35/00B82Y5/00
Inventor 陈苏云
Owner 江苏圣典医药科技有限公司
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