A kind of bone regeneration composite material and preparation method thereof
A composite material, bone regeneration technology, applied in tissue regeneration, prosthesis, medical science and other directions, can solve the problem of the mechanical properties of regenerative membrane materials need to be improved, and achieve good biodegradability, good biocompatibility, and short molding time. Effect
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Embodiment 1
[0050] 1) Synthesis of hydrophilic and hydrophobic segmented polymers
[0051] Put 1,8-octanediol and citric acid into a 250mL three-necked flask according to the molar ratio of 1:1, put it into an oil bath, adjust the temperature to 165°C, and let in nitrogen until the three substances are completely After melting, the temperature of the oil bath was adjusted to 140 °C, and the reaction was continued for 3 h. After the reaction, 100 mL of absolute ethanol was added to dissolve it completely, then the polymer prepolymer was precipitated with ultrapure water at a ratio of 1:1, and centrifuged at a centrifugal speed of 10,000 rpm / min for 10 min to retain the precipitate. The pellet centrifugation was repeated three times. Put it into a vacuum drying oven at 40°C to remove residual moisture to obtain a purified hydrophilic and hydrophobic segmented polymer.
[0052] 2) Double Bonding of Hydrophilic and Hydrophobic Fragmented Polymers
[0053] Add itaconic acid to the prepared ...
Embodiment 2
[0057] 1) Synthesis of hydrophilic and hydrophobic segmented polymers
[0058] Put 1,8-octanediol and citric acid into a 250mL three-necked flask according to the molar ratio of 1:1, put it into an oil bath, adjust the temperature to 165°C, and let in nitrogen until the three substances are completely After melting, the temperature of the oil bath was adjusted to 140 °C, and the reaction was continued for 3 h. After the reaction, 100 mL of absolute ethanol was added to dissolve it completely, then the polymer prepolymer was precipitated with ultrapure water at a ratio of 1:1, and centrifuged at a centrifugal speed of 10,000 rpm / min for 10 min to retain the precipitate. The pellet centrifugation was repeated three times. Put it into a vacuum drying oven at 40°C to remove residual moisture to obtain a purified hydrophilic and hydrophobic segmented polymer.
[0059] 2) Double Bonding of Hydrophilic and Hydrophobic Fragmented Polymers
[0060] Dissolve the hydrophilic and hydro...
Embodiment 3
[0064] 1) Synthesis of hydrophilic and hydrophobic segmented polymers
[0065] Put 1,8-octanediol and citric acid into a 250mL three-necked flask according to the molar ratio of 1:1, put it into an oil bath, adjust the temperature to 165°C, and let in nitrogen until the three substances are completely After melting, the temperature of the oil bath was adjusted to 140 °C, and the reaction was continued for 3 h. After the reaction, 100 mL of absolute ethanol was added to dissolve it completely, then the polymer prepolymer was precipitated with ultrapure water at a ratio of 1:1, and centrifuged at a centrifugal speed of 10,000 rpm / min for 10 min to retain the precipitate. The pellet centrifugation was repeated three times. Put it into a vacuum drying oven at 40°C to remove residual moisture to obtain a purified hydrophilic and hydrophobic segmented polymer.
[0066] 2) Double Bonding of Hydrophilic and Hydrophobic Fragmented Polymers
[0067] Add itaconic acid to the prepared ...
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