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Preparation method of water-soluble astaxanthin nanoemulsion and preparation method of heating type anti-fatigue eyeshade

A kind of astaxanthin, water-soluble technology, applied in the field of materials, can solve the problems of poor solubility, instability, and limit the practical application of natural astaxanthin, and achieve the effect of improving visual fatigue, high temperature stability, prevention and visual fatigue

Active Publication Date: 2020-12-15
ZHEJIANG OCEAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, natural astaxanthin is fat-soluble, has poor solubility in water-soluble systems, and is unstable under environmental factors such as light and heating, which will greatly limit the practical application of natural astaxanthin

Method used

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  • Preparation method of water-soluble astaxanthin nanoemulsion and preparation method of heating type anti-fatigue eyeshade
  • Preparation method of water-soluble astaxanthin nanoemulsion and preparation method of heating type anti-fatigue eyeshade
  • Preparation method of water-soluble astaxanthin nanoemulsion and preparation method of heating type anti-fatigue eyeshade

Examples

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Effect test

Embodiment 1

[0030] This implementation case shows a preparation method of a water-soluble astaxanthin nanoemulsion according to the following steps: Tween 80 is used as an emulsifier, and absolute ethanol is used as a co-emulsifier. The specific method is as follows:

[0031] 1) Mix Tween 80: absolute ethanol at a mass ratio of 1:1, stir magnetically at room temperature until fully dissolved, and record it as solution A.

[0032] 2) The astaxanthin extract was dissolved in absolute ethanol to reach a mass concentration of 10 mg / mL, which was recorded as astaxanthin ethanol solution.

[0033] 3) Add the astaxanthin ethanol solution to the solution A while stirring at room temperature according to the mass ratio of 1:2, and the obtained mixed solution is referred to as the solution B.

[0034] 4) Add corn oil to solution B at a ratio of 1:8 by mass to solution B, stir magnetically at room temperature until uniform, and record it as solution C.

[0035] 5) Add deionized water to solution C ...

Embodiment 2

[0037] This implementation case shows a preparation method of a water-soluble astaxanthin nanoemulsion according to the following steps: Tween 80 is used as an emulsifier, and absolute ethanol is used as a co-emulsifier. The specific method is as follows:

[0038] 1) Mix Tween 80: absolute ethanol at a mass ratio of 2:1, stir magnetically at room temperature until fully dissolved, and record it as solution A.

[0039] 2) The astaxanthin extract was dissolved in absolute ethanol to reach a mass concentration of 12 mg / mL, which was recorded as astaxanthin ethanol solution.

[0040] 3) The astaxanthin ethanol solution was added to the A solution at room temperature with stirring according to the mass ratio of 1:3, and the obtained mixed solution was recorded as the B solution.

[0041] 4) Add corn oil to solution B according to the mass ratio of 10%, stir magnetically at room temperature until uniform, and record it as solution C.

[0042] 5) Add deionized water into solution C ...

Embodiment 3

[0044] This implementation case shows a preparation method of a water-soluble astaxanthin nanoemulsion according to the following steps: Tween 80 is used as an emulsifier, and absolute ethanol is used as a co-emulsifier. The specific method is as follows:

[0045] 1) Mix Tween 80: absolute ethanol at a mass ratio of 1:2, stir magnetically at room temperature until fully dissolved, and record it as solution A.

[0046] 2) The astaxanthin extract was dissolved in absolute ethanol to reach a mass concentration of 13 mg / mL, which was recorded as astaxanthin ethanol solution.

[0047] 3) Add the astaxanthin ethanol solution to the A solution in a ratio of 1:4 by mass at room temperature while stirring, and add the mixed solution to the A solution, and record the mixed solution as the B solution.

[0048] 4) Add corn oil to solution B at a mass ratio of 1:12 to solution B, stir magnetically at room temperature until uniform, and record it as solution C.

[0049] 5) Add deionized wa...

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Abstract

The invention discloses a preparation method of a water-soluble astaxanthin nanoemulsion. The method is biological, environment-friendly, simple and easy to implement; the prepared astaxanthin nanoemulsion can be mutually dissolved with water according to any proportion, has relatively high temperature stability, and can be mixed with a hydrophilic matrix material according to the proportion requirement, for example, the astaxanthin nanoemulsion can be mutually dissolved with an aqueous solution system; the retention rate of the astaxanthin still reaches 90% or above after the astaxanthin nanoemulsion is heated at 60 DEG C for 4 h, and a heating type anti-fatigue eyeshade prepared from the astaxanthin nanoemulsion can give full play to the anti-oxidation and anti-fatigue effects of the astaxanthin and can prevent and improve eye discomfort symptoms such as asthenopia and dry eyes and the like.

Description

technical field [0001] The invention belongs to the field of materials, and in particular relates to a preparation method of a water-soluble astaxanthin nanoemulsion and a preparation method of a fever-type anti-fatigue eye mask. Background technique [0002] The chemical name of Astaxanthin is 3,3′-dihydroxy-4,4′-diketone-β,β′-carotene, which is an orange-red ketone carotenoid. Natural astaxanthin has super strong antioxidant activity, its antioxidant activity is 10 times stronger than β-carotene and lutein, and 100 times stronger than natural vitamin E[1-2]. Astaxanthin can not only inhibit the oxidation of food lipids induced by free radicals, but also has many biological activities such as scavenging free radicals in the body, anti-cancer, anti-tumor, and improving the body's immunity. In addition, astaxanthin has a certain preventive effect on some skin cancers and eye diseases. Therefore, astaxanthin has a very broad application prospect in food, medicine and other f...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/26A61K31/122A61P27/02A61P39/06A61F9/00A61F9/04
CPCA61K9/1075A61K9/0048A61K47/26A61K31/122A61P27/02A61P39/06A61F9/045A61F9/0008
Inventor 宋茹杨舒怡韦荣编
Owner ZHEJIANG OCEAN UNIV