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Phenylephrine hydrochloride containing liquid composition

A technology of phenylephrine hydrochloride and phenylephrine, which is applied in the field of liquid compositions containing phenylephrine hydrochloride and liquid compositions containing oxyepinephrine hydrochloride. issues of stability

Inactive Publication Date: 2020-12-15
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention patent of the above-mentioned patent number 2007800151423 applied for protection regardless of the mixture of phenylephrine hydrochloride and any additional drug active substances, and the stable pH range of the liquid medicine was 6.5-7.5, without considering the influence of the existence of individuality on the stability of the liquid medicine , that is, different additional active pharmaceutical substances and thus different excipients will affect the stability of a single composition

Method used

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  • Phenylephrine hydrochloride containing liquid composition
  • Phenylephrine hydrochloride containing liquid composition
  • Phenylephrine hydrochloride containing liquid composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1 (investigate the stability of the medicinal liquid of composition 1 under different pH value conditions)

[0053] prescription:

[0054] name Prescription amount name Prescription amount brompheniramine maleate 0.30g Phosphate buffer Appropriate amount Dextromethorphan Hydrobromide 0.50g Disodium edetate 0.20g Phenylephrine Hydrochloride 0.15g Anhydrous citric acid 4.05g glycerin 120.00g allura red 13.00mg polyethylene glycol 4000 120.00g Bright blue 5,30mg sucrose 350.00g grape essence 3ml Sorbic acid 1.01g Add purified water to 1000ml

[0055] Prepare 1000ml according to the described preparation method: first, add co-solvent and thickener into a clean container, add brompheniramine maleate and dextromethorphan hydrobromide, stir until dissolved, and obtain an additional drug active substance solution ; in another container, add solvent, phenylephrine hydrochloride, flavor...

Embodiment 2

[0062] Embodiment 2 (investigate the stability of the medicinal solution of composition 2 when different pH values)

[0063] name Prescription amount name Prescription amount Acetaminophen 28.00g Phosphate buffer Appropriate amount Dextromethorphan Hydrobromide 0.15g Disodium edetate 0.20g Phenylephrine Hydrochloride 0.35g Propyl gallate 1.55g Guaifenesin 18.00g allura red 11.00mg glycerin 100.00g Bright blue 3,30mg sucrose 250.00g apple flavor 2.00ml Sorbic acid 0.75g Add purified water to 1000ml

[0064] Prepare 1000ml according to the described preparation method. First, add cosolvent and thickener into a clean container, add paracetamol, guaiacol glyceryl ether, and dextromethorphan hydrobromide, and stir until dissolved to obtain additional Pharmaceutical active substance solution; in another container, add solvent, phenylephrine hydrochloride, flavoring agent, preservative, complexing agen...

Embodiment 3

[0071] Example 3 (to investigate the stability of the medicinal solution of composition 3 at different pH values).

[0072] prescription:

[0073] name Prescription amount name Prescription amount Chlorpheniramine maleate 0.30g Phosphate buffer Appropriate amount Dextromethorphan Hydrobromide 1.20g microcrystalline cellulose 8.0g Phenylephrine Hydrochloride 0.50g sodium benzoate 1.55g Acetaminophen 0.05g allura red 11.00mg glycerin 100.00g Sorbitol 650g Sucralose 2,36g apple flavor 2.00ml xanthan gum 1.50g Add purified water to 1000ml Disodium edetate 2.3g

[0074] Prepare 1000ml according to the preparation method, at first, join solubilizer, thickener in the clean container, add chlorpheniramine maleate, acetaminophen, dextromethorphan hydrobromide, stir until dissolving, obtain Additional drug active substance solution; in another container, add solvent, phenylephrine hydrochloride,...

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Abstract

The invention provides six liquid compositions containing phenylephrine hydrochloride. The six liquid compositions contain the following active substances: a composition 1: phenylephrine hydrochloride, brompheniramine maleate and dextromethorphan hydrobromide; a composition 2: phenylephrine hydrochloride, acetaminophen, guaiacol glyceryl ether and dextromethorphan hydrobromide; a composition 3: phenylephrine hydrochloride, chlorpheniramine maleate, acetaminophen and dextromethorphan hydrobromide; a composition 4: phenylephrine hydrochloride, acetaminophen and dextromethorphan hydrobromide; a composition 5: phenylephrine hydrochloride, acetaminophen and diphenhydramine hydrochloride; and a composition 6: phenylephrine hydrochloride, acetaminophen and guaiacol glyceryl ether. The inventor finds that the stability of the six liquid compositions is related to the pH value through research. The liquid composition can be used for treating respiratory diseases caused by cold, including virusinfection, such as influenza and cold, as well as allergy, sinusitis, rhinitis and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical technology research and development, and specifically relates to a liquid composition containing oxyepinephrine hydrochloride. More specifically, there are six liquid compositions containing phenylephrine hydrochloride. The stability of these six liquid compositions is related to the pH of the medicinal liquid. value related. Background technique [0002] Phenylephrine hydrochloride is an α-adrenergic receptor agonist, which has the effect of constricting blood vessels and raising blood pressure. It is a strong vasoconstrictor and is used as a nasal decongestant and electrocardiographic agent. Phenylephrine hydrochloride Toxin can also cause pulmonary vasoconstriction, and subsequent increase in pulmonary artery pressure, vasoconstriction under the respiratory mucosa, etc., often combined with antiallergic drugs, expectorants, antitussives, antipyretics, etc. to treat fever caused by colds , stuffy ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/137A61K45/06A61K31/485A61K31/09A61K31/167A61K31/135A61K31/4402A61K47/04A61K47/02A61K47/12A61K9/00A61P11/00A61P31/12A61P31/16A61P37/08A61P11/02
CPCA61K9/0053A61K31/09A61K31/135A61K31/137A61K31/167A61K31/4402A61K31/485A61K45/06A61K47/02A61K47/12A61P11/00A61P11/02A61P31/12A61P31/16A61P37/08A61K2300/00
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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