A kind of processing method of matrine
A processing method and technology of matrine, applied in the field of phytochemistry, can solve problems such as rising, achieve the effects of reducing production cost, reducing raw material loss rate, increasing binding performance and adsorption capacity
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[0044] The present invention also provides a preparation method of a metal complex of matrine, comprising: mixing matrine and ferric chloride, then adding absolute ethanol at a ratio of 1g:10-20mL of solid to liquid, stirring and dissolving , reflux at high temperature, then dropwise add hydrochloric acid solution until there is no precipitation in the reaction system, lower the temperature, let it stand for cooling for 10-12 hours, filter, then rinse the precipitate with absolute ethanol for 1-2 times, and then use absolute ethanol for heavy Crystallization yielded a yellow matrine-iron complex.
[0045] In a specific implementation scenario, the molar ratio of matrine and ferric chloride is 1:1-1.2, and the concentration of hydrochloric acid solution is 1-1.2mol / L; the temperature of the above-mentioned high-temperature reflux is 80-100°C, and the time is 40 -60min.
[0046] The invention also provides a composition for preparing antineoplastic drugs, which contains the met...
Embodiment 1
[0050] A processing method of matrine, comprising the following steps:
[0051] 1) Dissolve matrine and methylene succinic acid in a chloroform-dodecanol system with 5 times the weight and a volume ratio of 1:1, and then add pentaerythritol triacrylate, salicylic hydroxamic acid, and trimethoxyallyl Base silane and azobisisobutyronitrile, vortex mixed for 30 minutes to form a homogeneous system, then flow nitrogen gas with a flow rate of 2.5 L / min for 20 minutes, and then place the system in a closed environment with a temperature of 50 ° C for 2.5 hours, and the reaction is over Finally, elute the template molecule matrine with a volume ratio of 9:1 methanol:acetic acid, then dry, grind, and pass through a 200-mesh sieve to obtain the molecularly imprinted material; the above-mentioned matrine, methylene succinic acid, The weight ratio of pentaerythritol triacrylate, salicylhydroxamic acid, trimethoxyallyl silane and azobisisobutyronitrile is 0.1:1.7:6.7:0.003:0.005:0.05;
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Embodiment 2
[0058] A kind of processing method of matrine, and the difference of embodiment 1 only lies in:
[0059] In step 1), the weight ratio of matrine, methylene succinic acid, pentaerythritol triacrylate, salicylhydroxamic acid, trimethoxyallyl silane and azobisisobutyronitrile is 1.3:7.5:33: 0.03:0.015:2.5; the system was reacted in a closed environment at a temperature of 45°C for 3 hours to prepare a molecularly imprinted material;
[0060] Step 2) in, the raw material selects the mountain bean root for use;
[0061] In step 3), molecularly imprinted materials 0.75 times the weight of the raw materials are added to the soaking liquid to form a mixed system, and then the mixed system is sent to the ultrasonic extraction equipment. The output power of the ultrasonic wave is 500W, the frequency is 20kHz, and the extraction temperature is 25 Under the condition of ℃, extract for 25 minutes, the intermittent auxiliary operation of the above ultrasonic wave is as follows: the number ...
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