Degradable tooth extraction wound filling composition and preparation method and application thereof

A technology for filling composition and tooth extraction wound, which is applied in the field of biomedical materials for oral care, can solve the problems of unstable tooth extraction socket, short action time, poor plasticity, etc., and achieves no pressing, small foreign body sensation, and good plasticity. Effect

Active Publication Date: 2022-08-05
诺一迈尔(山东)医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the technical problem of short action time caused by the poor plasticity and good water solubility of the existing tooth extraction socket filling composition, which cannot be stabilized in the tooth extraction socket, a degradable tooth extraction wound filling composition and its preparation method and application are provided

Method used

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  • Degradable tooth extraction wound filling composition and preparation method and application thereof
  • Degradable tooth extraction wound filling composition and preparation method and application thereof
  • Degradable tooth extraction wound filling composition and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] A degradable tooth extraction wound filling composition, comprising the following raw materials in parts by weight: 6 g of calcium stearate, 3 g of alginic acid / chitosan complex, 2 g of bioactive glass, and 6 g of tocopherol acetate;

[0030] Preparation method of degradable tooth extraction wound filling composition: Weigh the components according to the formula, mechanically mix the dry solid components, gradually add the liquid component tocopherol acetate after mixing, mechanically mix at room temperature, and process to a uniform putty in the form of a degradable tooth extraction wound filling composition. Physical picture such as figure 1 As shown, the degradable tooth extraction wound filling composition of this embodiment can be arbitrarily deformed in the tooth socket, and can fully fill especially the irregular tooth socket.

[0031] The preparation method of the alginic acid / chitosan complex in this example is as follows: dissolving 0.1 g of sodium alginate ...

Embodiment 2

[0034] Degradable tooth extraction wound filling composition, comprising the following raw materials in parts by weight: 5 g of calcium stearate, 4 g of alginic acid / chitosan complex, 2 g of bioactive glass, 5 g of tocopherol acetate, and 1 g of poloxamer (Pluronic L35);

[0035] The preparation method of the degradable tooth extraction wound filling composition is the same as that of Example 1.

[0036] The preparation method of the alginic acid / chitosan complex in this example is the same as that in Example 1.

[0037] The bioactive glass in this example is the same as Example 1.

[0038] The physical characteristics of the composition obtained in this example are similar to those of the composition in Example 1, but the water resistance is weakened, the swelling time is shortened in Example 1, and the product viscosity of the composition in this example is increased.

[0039] The amount of time the composition remains in the extraction socket can be controlled by adjusting...

Embodiment 3

[0042] A degradable tooth extraction wound filling composition, comprising the following raw materials in parts by weight: 4 g of calcium stearate, 6 g of alginic acid / chitosan complex, 1 g of bioactive glass, and 6 g of tocopherol acetate;

[0043] The preparation method of the degradable tooth extraction wound filling composition is the same as that of Example 1.

[0044] The preparation method of the alginic acid / chitosan complex in this example is as follows: preparing 20 mL of sodium alginate-acetic acid aqueous solution with a concentration of 0.3% pH=5 and 5 mL of a chitosan-acetic acid aqueous solution with a concentration of 0.15% pH=5, The chitosan-acetic acid aqueous solution was slowly dropped into the sodium alginate-acetic acid aqueous solution under ultrasonic conditions, and after stirring for 30 minutes, the sodium alginate / chitosan gel microspheres were precipitated, and the gel microspheres were obtained by centrifugation for 20 minutes. The gel microspheres...

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Abstract

The invention relates to a degradable tooth extraction wound filling composition, a preparation method and application thereof, and is characterized in that it comprises the following raw materials in parts by weight: 20-60 parts of calcium stearate, 10-40 parts of alginic acid / chitosan composite, biological 5 to 30 parts of active glass, 10 to 60 parts of tocopherol acetate, and 0 to 30 parts of poloxamer; including the following steps: mechanically mixing calcium stearate, alginic acid / chitosan composite, bioactive glass, poloxamer loxamer, then add tocopherol acetate, mix evenly to form a marl-like mixture, and obtain a degradable tooth extraction wound filling composition after shaping, packaging and sterilization; Composition for preventing tooth extraction complications. The degradable tooth extraction wound filling composition of the invention is a putty-like material that can be arbitrarily shaped and deformed, can fill tooth extraction sockets of any shape, has a long action time, stabilizes the hemostatic effect, and at the same time has the functions of repairing and bacteriostasis.

Description

technical field [0001] The invention relates to the technical field of biomedical materials for oral care, in particular to a degradable tooth extraction wound filling composition and a preparation method and application thereof. Background technique [0002] In oral and maxillofacial surgery, tooth extraction is the most basic and widely used operation. Like other operations, it will cause varying degrees of damage to local soft and hard tissues, causing bleeding, swelling, pain, infection and other symptoms and signs. Post-bleeding is the most common postoperative complication that, if not managed properly, can lead to more serious complications. The compression method is currently the most commonly used method for hemostasis of tooth extraction wounds. Usually, cotton balls or gauze balls are placed in the tooth extraction wounds and occluded for a period of time to achieve the purpose of compression and hemostasis. However, this hemostatic method has certain risks, such...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/02A61L31/14A61L31/16A61L24/02A61L24/00A61L24/08
CPCA61L31/129A61L31/026A61L31/16A61L31/14A61L24/0015A61L24/0094A61L24/02A61L24/001A61L2400/04A61L2300/41A61L2300/418A61L2300/402
Inventor 李明郭刚孟洋王丽朱晓强
Owner 诺一迈尔(山东)医学科技有限公司
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