Degradable tooth extraction wound filling composition and preparation method and application thereof
A technology for filling composition and tooth extraction wound, which is applied in the field of biomedical materials for oral care, can solve the problems of unstable tooth extraction socket, short action time, poor plasticity, etc., and achieves no pressing, small foreign body sensation, and good plasticity. Effect
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Embodiment 1
[0029] A degradable tooth extraction wound filling composition, comprising the following raw materials in parts by weight: 6 g of calcium stearate, 3 g of alginic acid / chitosan complex, 2 g of bioactive glass, and 6 g of tocopherol acetate;
[0030] Preparation method of degradable tooth extraction wound filling composition: Weigh the components according to the formula, mechanically mix the dry solid components, gradually add the liquid component tocopherol acetate after mixing, mechanically mix at room temperature, and process to a uniform putty in the form of a degradable tooth extraction wound filling composition. Physical picture such as figure 1 As shown, the degradable tooth extraction wound filling composition of this embodiment can be arbitrarily deformed in the tooth socket, and can fully fill especially the irregular tooth socket.
[0031] The preparation method of the alginic acid / chitosan complex in this example is as follows: dissolving 0.1 g of sodium alginate ...
Embodiment 2
[0034] Degradable tooth extraction wound filling composition, comprising the following raw materials in parts by weight: 5 g of calcium stearate, 4 g of alginic acid / chitosan complex, 2 g of bioactive glass, 5 g of tocopherol acetate, and 1 g of poloxamer (Pluronic L35);
[0035] The preparation method of the degradable tooth extraction wound filling composition is the same as that of Example 1.
[0036] The preparation method of the alginic acid / chitosan complex in this example is the same as that in Example 1.
[0037] The bioactive glass in this example is the same as Example 1.
[0038] The physical characteristics of the composition obtained in this example are similar to those of the composition in Example 1, but the water resistance is weakened, the swelling time is shortened in Example 1, and the product viscosity of the composition in this example is increased.
[0039] The amount of time the composition remains in the extraction socket can be controlled by adjusting...
Embodiment 3
[0042] A degradable tooth extraction wound filling composition, comprising the following raw materials in parts by weight: 4 g of calcium stearate, 6 g of alginic acid / chitosan complex, 1 g of bioactive glass, and 6 g of tocopherol acetate;
[0043] The preparation method of the degradable tooth extraction wound filling composition is the same as that of Example 1.
[0044] The preparation method of the alginic acid / chitosan complex in this example is as follows: preparing 20 mL of sodium alginate-acetic acid aqueous solution with a concentration of 0.3% pH=5 and 5 mL of a chitosan-acetic acid aqueous solution with a concentration of 0.15% pH=5, The chitosan-acetic acid aqueous solution was slowly dropped into the sodium alginate-acetic acid aqueous solution under ultrasonic conditions, and after stirring for 30 minutes, the sodium alginate / chitosan gel microspheres were precipitated, and the gel microspheres were obtained by centrifugation for 20 minutes. The gel microspheres...
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