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Porous gradient scaffold and preparation method based on primitive and diamond surface structural units

A technology of curved surface structure and gradient, applied in the field of biomedical implant materials, can solve the problems of the large gap in the performance of human bone tissue and the single structure of the bionic scaffold, so as to improve the biocompatibility, avoid local stress concentration, and shorten the design cycle. Effect

Active Publication Date: 2022-02-22
UNIV OF SCI & TECH BEIJING
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The main purpose of the present invention is to provide a porous gradient support based on Primitive and Diamond curved surface structural units and a preparation method. The porous gradient support with a mixed lattice is formed by combining an inner support structure and an outer support structure, and has good mechanics and Biocompatibility, giving full play to the respective advantages of Primitive and Diamond surface structural units, that is, Primitive curved surface structural units have high strength and can replace compact bone to provide support strength; Diamond curved surface structural units have high permeability and can replace cancellous bone to promote Material transport, and the structure of the structural unit is based on the implicit function expression, which improves the accuracy of design and forming, so as to solve the technical problems of the single structure of the bionic scaffold in the prior art and the large gap between the performance and the performance of human bone tissue

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  • Porous gradient scaffold and preparation method based on primitive and diamond surface structural units
  • Porous gradient scaffold and preparation method based on primitive and diamond surface structural units
  • Porous gradient scaffold and preparation method based on primitive and diamond surface structural units

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preparation example Construction

[0089] The present invention also discloses a method for preparing a mixed lattice porous gradient scaffold based on Primitive and Diamond curved surface structural units. The preparation method specifically includes the following steps:

[0090] S1, Constructing structural expressions: According to the required structure and performance characteristics of the implant, determine the size and porosity of the Primitive and Diamond surface structural units that need to be selected, and then determine the expressions of the inner stent structure and the outer stent structure , and select the appropriate S-type function, connect the expressions of the inner layer support structure and the outer layer support structure through the S-type transition function, and obtain the expression of the mixed lattice porous gradient structure based on Primitive and Diamond surface structural units;

[0091] S2, Constructing the gradient structure: input the expression of the mixed lattice porous ...

Embodiment 1

[0100] A mixed lattice porous gradient scaffold based on Diamond and Primitive surface structural units, the scaffold is a columnar porous structure with a size of The porosity gradient along the radial direction is 50%-80%-50%, including the inner stent structure 1 and the outer stent structure 2, and the inner stent structure 1 and the outer stent structure 2 are connected by an S-shaped transition function; The expression of the S-type transition function is

[0101] The porosity of the inner support structure 1 is 80%, forming a high-porosity and low-density area in the inner layer; the inner support structure 1 is formed by multiple Diamond surface structural unit arrays, and the corresponding implicit function expression is

[0102]

[0103] The size of the Diamond surface structure unit is 2mm, expressed by the implicit function controlled;

[0104] The porosity of the outer support structure 2 is 50%, forming a low-porosity and high-density area in the outer...

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Abstract

The invention provides a porous gradient support based on Primitive and Diamond curved surface structural units and a preparation method thereof. The porous gradient support includes an inner layer support structure and an outer layer support structure, and the inner layer support structure is composed of a plurality of Diamond curved surface structural units along the The three-dimensional array of length, width and height is formed, and the outer support structure is formed by a plurality of Primitive curved surface structural units along the three-dimensional array of length, width and height; the outer support structure is arranged on the outside of the inner support structure , and the porosity of the porous gradient scaffold changes in a gradient from the inner scaffold structure to the outer scaffold structure. The porous gradient scaffold with mixed lattice has good mechanics and biocompatibility.

Description

technical field [0001] The invention relates to the technical field of biomedical implant materials, in particular to a porous gradient support based on Primitive and Diamond curved surface structural units and a preparation method. Background technique [0002] In daily life, due to aging, sports trauma, disease and other reasons, it often leads to large-scale defects of human bones, which seriously reduces people's quality of life. Artificial prosthesis replacement surgery is an important method for the treatment of large-scale bone defects. However, most of the currently developed porous prosthetic scaffolds are traditional straight-rod-based single-lattice scaffolds, which cannot match the human body well in terms of mechanics and biocompatibility. On the one hand, the straight-rod-based lattice structure is prone to stress concentration at the node positions between the rods, and fails prematurely under the action of cyclic stress, and the specific surface area of ​​the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/28
CPCA61F2/28A61F2/30942A61F2002/3097A61F2002/30985A61F2250/0023
Inventor 路新徐伟侯辰锦于爱华潘宇刘博文张策张嘉振曲选辉
Owner UNIV OF SCI & TECH BEIJING