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Mixed lattice porous gradient scaffold and preparation method

A gradient and lattice technology, applied in the field of biomedical implant materials, can solve the problems of large gaps in human bone tissue performance and single structure, and achieve favorable cell adhesion, high controllability, and favorable specific surface area Effect

Active Publication Date: 2022-02-11
UNIV OF SCI & TECH BEIJING
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The main purpose of the present invention is to provide a mixed lattice porous gradient scaffold and its preparation method. The porous gradient scaffold with mixed lattice adopts multiple scaffold structures and is formed by transitional connection through S-shaped functions, and the scaffold structure adopts multiple curved surfaces. The formation of structural unit arrays makes the porous gradient scaffold have good mechanical and biocompatibility, and fully utilizes the advantages of the curved surface structure. It can replace compact bone to provide support strength and replace cancellous bone to promote material transport, and the structure of the curved surface structural unit is controllable , to improve the accuracy of design and forming, to solve the technical problems of single bionic scaffold structure and performance gap with human bone tissue in the prior art

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  • Mixed lattice porous gradient scaffold and preparation method

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preparation example Construction

[0088] The invention also discloses a preparation method of the mixed lattice porous gradient scaffold, which specifically includes the following steps:

[0089] S1, constructing the structure expression, according to the required structure and performance characteristics of the implant, determine the size and porosity of the Primitive and Gyroid surface structural units that need to be selected, and then determine the structure of the inner stent structure 1 and the outer stent structure 2 expression, and connect the expressions of the inner support structure 1 and the outer support structure 2 through the S-type transition function to obtain the expression of the mixed lattice porous gradient structure based on Primitive and Gyroid surface structural units;

[0090] S2. Construct the gradient structure, input the expression of the mixed lattice porous gradient structure and the size and shape parameters of the gradient scaffold into MATHEMATICA software for visualization, and...

Embodiment 1

[0099] A hybrid lattice porous gradient scaffold based on Primitive and Gyroid surface structural units, the porous gradient scaffold is a columnar porous structure with a size of The porosity gradient along the radial direction is 50%-70%-50%, including the inner stent structure 1 and the outer stent structure 2, and the inner stent structure 1 and the outer stent structure 2 are connected by an S-shaped transition function; Among them: the expression of the S-type transition function is

[0100] The porosity of the inner support structure 1 is 70%, forming a high-porosity and low-density area in the inner layer; the inner support structure 1 is formed by a plurality of Gyroid surface structural unit arrays, and the corresponding implicit function expression is:

[0101]

[0102] The size of the Gyroid surface structure unit is 2mm, expressed by the implicit function Get under control.

[0103] The porosity of the outer support structure 2 is 50%, forming an outer ...

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Abstract

The invention provides a mixed lattice porous gradient scaffold and a preparation method thereof. The mixed lattice porous gradient scaffold includes a plurality of scaffold structures, and the plurality of scaffold structures are connected by a smooth transition through an S-shaped function; each of the The support structure is formed by arraying a plurality of curved surface structural units along three dimensions of length, width and height, and the curved surface structural unit is controlled by an implicit function expression; among the plurality of support structures, each curved surface in the support structure The structure of the structural unit is different from that of the curved surface structural unit in the other stent structures. The porous gradient scaffold has good mechanical and biocompatibility, gives full play to the advantages of the curved surface structure, can replace compact bone to provide support strength and replace cancellous bone to promote material transport, and the structure of the curved surface structure unit is controllable, which improves the design and Forming accuracy.

Description

technical field [0001] The invention relates to the technical field of biomedical implant materials, in particular to a mixed lattice porous gradient scaffold and a preparation method. Background technique [0002] Titanium and titanium alloys have low elastic modulus, high specific strength, excellent corrosion resistance and good biocompatibility, and are widely used in the field of bone repair. However, its elastic modulus value (~110GPa) is still much higher than that of natural bone (cancellous bone 0.01~3GPa, compact bone 3~30GPa), and the phenomenon of "stress shielding" will appear after implantation, resulting in no Bacteria loosen, thereby causing the implant to fail prematurely; and the structure is dense, and the biocompatibility is poor. [0003] Through the design of the porous structure, that is, adjusting the porosity, pore size, shape and distribution of the pores, implant materials with good mechanical and biocompatibility can be obtained, that is, implant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06F30/17A61L27/06A61L27/56B22F10/28B22F3/11B22F5/00B33Y10/00B33Y80/00G06T17/00G06F113/10
CPCA61L27/56A61L27/06B22F3/11B22F5/00B33Y10/00B33Y80/00G06F30/17G06T17/00A61L2430/02G06F2113/10
Inventor 路新徐伟于爱华侯辰锦潘宇刘博文张嘉振
Owner UNIV OF SCI & TECH BEIJING