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Composition for promoting myogenesis, containing processed ginseng extract

A ginseng extraction and composition technology, applied in the field of compositions for promoting muscle differentiation, can solve problems such as unrecorded and implied inhibition of myostatin and the like

Pending Publication Date: 2021-01-15
GREEN CROSS HEALTH SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, Korean Patent No. 1595426 describes a composition for treating sarcopenia comprising a processed ginseng extract with increased content of ginsenoside Rh2 and ginsenoside Rg3, but does not describe or suggest that the present invention suppresses Myostatin and its effect on promoting muscle differentiation

Method used

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  • Composition for promoting myogenesis, containing processed ginseng extract
  • Composition for promoting myogenesis, containing processed ginseng extract
  • Composition for promoting myogenesis, containing processed ginseng extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094]

[0095] 250 g of ginseng powder and 750 g of wheat bran were added, and sterilized with an autoclave at 121° C. and 1.5 atmospheres. Add 2L of sterile water to the sterilized medium and mix, then inoculate the Aspergillus niger suspension (5×10 5 spore / medium weight g), and cultured at 28°C for 7 days. After the cultivation was completed, 0.02M sodium acetate buffer solution was added and mixed, and the medium was then filtered. The filtered culture solution was filtered and concentrated using an ultrafiltration membrane (above 100 kDa) to obtain 60 g of enzyme solution. 30 g of the enzyme solution was added to 200 g of the ginseng powder of Comparative Example 1, and after culturing at 28° C. for 18 hours, ethanol was added to precipitate the enzyme, and the supernatant was concentrated. After adding 2 L of purified water to 200 g of the above concentrate, 250 g of citric acid was added, and stirred at 50° C. for 18 hours. After the reaction was completed, 70% et...

Embodiment 2

[0096]

[0097] 250 g of ginseng powder and 750 g of wheat bran were added, and sterilized with an autoclave at 121° C. and 1.5 atmospheres. Add 2L of sterile water to the sterilized medium and mix, then inoculate the Aspergillus niger suspension (5×10 5 spore / medium weight g), and cultured at 28°C for 7 days. After the cultivation was completed, 0.02M sodium acetate buffer solution was added and mixed, and the medium was then filtered. The filtered culture solution was filtered and concentrated using an ultrafiltration membrane (above 100 kDa) to obtain 60 g of enzyme solution. 30 g of the enzyme solution was added to 200 g of the ginseng concentrate of Comparative Example 2, and after culturing at 28° C. for 18 hours, ethanol was added to precipitate the enzyme, and the supernatant was concentrated. After adding 2 L of purified water to 200 g of the above concentrate, 250 g of citric acid was added, and stirred at 50° C. for 18 hours. After the reaction was completed, 7...

Embodiment 3

[0098]

[0099] 250 g of ginseng powder and 750 g of wheat bran were added, and sterilized with an autoclave at 121° C. and 1.5 atmospheres. Add 2L of sterile water to the sterilized medium and mix, then inoculate the Aspergillus niger suspension (5×10 5 spore / medium weight g), and cultured at 28°C for 7 days. After the cultivation was completed, 0.02M sodium acetate buffer solution was added and mixed, and the medium was then filtered. The filtered culture solution was filtered and concentrated using an ultrafiltration membrane (above 100 kDa) to obtain 60 g of enzyme solution. 30 g of the enzyme solution was added to 200 g of the ginseng concentrate powder of Comparative Example 3, and after culturing at 28° C. for 18 hours, ethanol was added to precipitate the enzyme, and the supernatant was concentrated. After adding 2 L of purified water to 200 g of the above concentrate, 250 g of acetic acid was added, and stirred at 50° C. for 8 hours. After the reaction was comple...

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PUM

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Abstract

The present invention relates to a composition for promoting myogenesis, containing, as an active ingredient, a processed ginseng extract in which a trace amount of a ginsenoside ingredient is increased. It has been ascertained that the processed ginseng extract promotes the differentiation of myoblasts into muscle and inhibits muscle atrophy caused by myostatin, which is a myogenesis inhibitory factor, and thus it is expected that a composition for preventing or treating muscle disorder-related diseases, having excellent effects, can be developed.

Description

technical field [0001] The present invention relates to a composition for promoting muscle differentiation comprising processed ginseng extract, and more specifically, to a composition for preventing or treating muscle diseases comprising processed ginseng extract as an active ingredient , the trace amount of ginsenoside components having the effect of promoting muscle differentiation in the processed ginseng extract increases. Background technique [0002] Muscle is the largest tissue in the human body. Ensuring an appropriate amount of muscle in the human body is essential in maintaining the structure of the human body, enabling the individual organs of the body to perform their respective functions, and preventing various diseases. [0003] Muscle is mainly divided into smooth muscle (smooth muscle), cardiac muscle (cardiac muscle), skeletal muscle (skeletal muscle). Skeletal muscles make up a significant portion of our overall body and facilitate the movement of our bo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K31/704A23L33/105A61P21/00
CPCA61P21/00A23L33/105A23V2002/00A61K2236/00A61K36/258A23V2200/316A61K31/704A23V2250/2124A23L33/40A61K9/0056A61K2236/19A61K2236/51
Inventor 朴宣奎金点溶刘泳孝张珉廷吴畅泽林玟姝李宽洙李夷李允赫俞载喆
Owner GREEN CROSS HEALTH SCI
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