Preparation method of thioester compounds

A compound and thioester technology, applied in the fields of organic chemistry, chemical instruments and methods, organic chemistry, etc., can solve problems such as unpleasant smell and catalyst poisoning, and achieve strong designability, easy operation and good reaction applicability. Effect
CN112239384AActive Publication Date: 2021-01-19ZHEJIANG SCI-TECH UNIV
8 Cites 4 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG SCI-TECH UNIV
Publication Date
2021-01-19

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a preparation method of thioester compounds, wherein the method comprises the following steps: adding nickel trifluoromethanesulfonate, 4,4'-di-tert-butyl-2,2'-dipyridyl, carbonyl molybdenum, potassium carbonate, zinc iodide, water, arylboronic acid and sulfonyl chloride into an organic solvent, gathering, reacting at the temperature of 120 DEG C for 16 hours, and after thereaction is completed, carrying out after-treatment to obtain the thioester compound. The preparation method has the advantages of simple operation, cheap and easily available reaction starting raw materials, strong substrate designability, wide substrate functional group tolerance range, high reaction efficiency, and no need of additional oxidants and reducing agents by using sulfonyl chloride as a sulfur source. Various thioester compounds can be synthesized according to actual requirements, so that the practicability of the method is widened while the operation is convenient.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of organic synthesis, in particular to a preparation method of a thioester compound. Background technique

[0002] Thioester compounds are a very important class of skeleton molecules, which exist in various natural products and drug molecules (Tetrahedron Lett. 1996, 37, 4305-4308). Its special structure enables thioester compounds to have significant physiological activity and are widely used in the fields of medicine and pesticides (J. Med. Chem. 2014, 57, 2832-2842). Thioester compounds are also of great significance in organic synthesis. As an air-stable and convenient acyl donor, they have been widely used in the synthesis of various aldehydes, ketones, esters and amides. In addition, thioester compounds have also been successfully applied to protein synthesis (Science 1994, 266, 776-779).

[0003]

[0004] The method of synthesizing thioester compounds in current literature reports is mainly to directly ob...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More