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Toothpaste for developing oral helicobacter pylori and preparation method thereof

A technology of Helicobacter pylori and oral cavity, which is applied in the field of biomedicine, can solve the problems of cumbersome detection methods and inability to detect in vivo, and achieve the effect of good stability and simple preparation process

Inactive Publication Date: 2021-01-26
SHANGHAI UNIV OF MEDICINE & HEALTH SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this detection method is cumbersome and cannot be detected in vivo. If a convenient detection method and product are developed, there are still certain challenges

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Preparation of chromogenic gold nanoparticles

[0023] Add ethylenediamine to the nano-gold sol with a mass fraction of 1% and a particle size of 5nm surface carboxyl groups, and use a cell ultrasonic pulverizer to ultrasonically disperse with a power of 600w and a time of 15min; then add 1% sodium copper chlorophyllin and Aptamer, add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) and N-hydroxysuccinimide (NHS) with a mass concentration of 1%, and stir for 12 Hours, washed and dried to prepare a color developer.

[0024] (2) Preparation of toothpaste developed by oral Helicobacter pylori

[0025] The ingredients and mass ratio are: silicon dioxide friction agent 40%, sodium chloride 1%, carboxymethyl cellulose 0.8%, sodium lauryl sulfate 1.0%, glycerin 10%, sweet orange oil 0.6%, peppermint essence 0.1%, 1% color developer, and water as the balance, after fully stirring and standing still, it can be filled into toothpaste.

[0026] Plaque appears green.

Embodiment 2

[0028] (1) Preparation of chromogenic gold nanoparticles

[0029] Add ethylenediamine to the nano-gold sol with a mass fraction of 5% and a particle size of 5nm and surface carboxyl groups, and use a cell ultrasonic pulverizer to ultrasonically disperse with a power of 400w and a time of 20min; then add 1% tartrazine and aptamer respectively, Add 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) and N-hydroxysuccinimide (NHS) with a mass concentration of 1%, stir and react for 12 hours, wash and dry Dry to prepare a color developer.

[0030] (2) Preparation of toothpaste developed by oral Helicobacter pylori

[0031] The ingredients and mass ratio are: calcium carbonate friction agent 30%, potassium chloride 1%, carboxymethyl cellulose 1.5%, sodium lauryl sulfate 3.0%, glycerin 25%, sweet orange oil 7.5%, white tea essence 0.5% %, 2% color developer, and water as the balance, after being fully stirred and left to stand, it is filled into toothpaste.

[0032] Plaque appear...

Embodiment 3

[0034] (1) Preparation of chromogenic gold nanoparticles

[0035] Add ethylenediamine to the nano-gold sol with a mass fraction of 5% and a particle size of 5nm and a carboxyl group on the surface, and use a cell ultrasonic pulverizer to ultrasonically disperse it with a power of 300w and a time of 30min; then add 1% erythrosine and appropriate Ligand, adding 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) and N-hydroxysuccinimide (NHS) with a mass concentration of 1%, stirred for 12 hours , washed and dried to prepare a color developer.

[0036] (2) Preparation of toothpaste developed by oral Helicobacter pylori

[0037] The ingredients and mass ratio are: silicon dioxide friction agent 50%, sodium chloride 5%, carboxymethyl cellulose 1.0%, sodium lauryl sulfate 5.0%, glycerin 20%, sweet orange oil 7.5%, orange flavor 0.5% essence, 5% color developer, and water as the balance. After fully stirring and standing still, it is filled into toothpaste.

[0038] Plaque appear...

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Abstract

The invention provides a coloring agent for developing oral helicobacter pylori and a preparation method thereof. The preparation method specifically comprises the following steps of: connecting the coloring agent and an aptamer to the surface of nanogold to prepare a color-developing nano material; and adding the nano material into toothpaste to prepare the toothpaste for developing oral helicobacter pylori. The toothpaste provided by the invention has the advantages that (1) the prepared toothpaste has a color developing effect on helicobacter pylori and can reflect the condition of dental plaque; and (2) the preparation process is simple and the obtained product is good in stability.

Description

technical field [0001] The invention relates to a biological staining agent and a preparation method thereof, which is used for the staining of oral Helicobacter pylori and a preparation method of the toothpaste, belonging to the field of biomedicine. Background technique [0002] Toothpaste is one of the commonly used oral products. Its functions mainly include two parts. One is to remove bad breath and peculiar smell, antibacterial and anti-inflammatory, so as to make breath fresh and refreshing. At present, natural plant toothpaste is a class of toothpaste that contains natural plant extracts and has effects such as anti-inflammatory, deodorant, and pain relief. The active ingredients in natural plant toothpaste can be absorbed through the oral mucosa when brushing teeth, organically combining tooth cleaning and prevention of dental diseases, and play a better role in removing bad breath, preventing oral inflammation, strengthening teeth, and removing bacteria on the toot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/19A61K8/41A61K8/58A61K8/60A61Q11/00
CPCA61K8/19A61K8/606A61K8/41A61K8/58A61Q11/00A61K2800/413A61K2800/45
Inventor 朱君吴宁李伟
Owner SHANGHAI UNIV OF MEDICINE & HEALTH SCI
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