Application of ganoderma acid a and its derivatives or ganoderma total triterpenoids in the preparation of medicines for treating eye diseases

A technology of Ganoderma lucidum total triterpenes and Ganoderma acid, which is applied in the field of biomedicine, can solve the problems of cataract, achieve clear effect, alleviate lacrimal gland and corneal lesions, and have high safety effects

Active Publication Date: 2021-09-07
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is still no effective drug treatment for cataract, and surgery is the only treatment at present

Method used

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  • Application of ganoderma acid a and its derivatives or ganoderma total triterpenoids in the preparation of medicines for treating eye diseases
  • Application of ganoderma acid a and its derivatives or ganoderma total triterpenoids in the preparation of medicines for treating eye diseases
  • Application of ganoderma acid a and its derivatives or ganoderma total triterpenoids in the preparation of medicines for treating eye diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 Ganoderma lucidum total triterpenes

[0023] Take Ganoderma lucidum fruiting bodies, dry at 70°C for 6 hours, pulverize, and pass through a No. 3 sieve to obtain coarse powder. Take the coarse powder, put it into the chromatography column, make the column height ratio between 12:1, add 10 times the amount of petroleum ether, soak for 24 hours, collect the seepage, then add 10 times the amount of ethanol and water successively, and collect the seepage respectively , combined petroleum ether and ethanol leaching seepage; combined seepage through ADS-8 macroporous resin, followed by elution with 20%, 30%, 40%, 50%, 75% and 100% ethanol solution , flow rate 1.5bv, collect the eluent eluted with ethanol with a volume fraction above 50%, and recover the solvent under reduced pressure. Through preparative grade OSD-C18 column, further refining, collect 10 kinds of ganoderma acid (ganoderic acid C, ganoderma acid C2, ganoderma acid G, ganocid ac...

Embodiment 2

[0024] Embodiment 2 pharmacodynamic experiment

[0025] 1. Instruments and reagents

[0026] 1.1 Feed production

[0027] The mouse maintenance feed (Beijing Huafukang Biotechnology Co., Ltd.) was crushed, and the total triterpenes of Ganoderma lucidum and an appropriate amount of water were added, and mixed evenly. The feed contains Ganoderma acid C, Ganoderma acid C2, Ganoderma acid G, Ganoderma acid B, Ganoderma acid B, Ganoderma acid A, Ganoderma acid H, Ganoderma acid D, Ganoderma acid D, Ganoderma acid F, the specific contents are shown in Table 1 , thus obtaining a feed containing total triterpenoids of Ganoderma lucidum.

[0028] Table 1

[0029]

[0030] The maintenance feed for mice (Beijing Huafukang Biotechnology Co., Ltd.) was crushed, and Ganoderma acid A and an appropriate amount of distilled water were added, and mixed evenly. The ganoderma acid A contained in the feed is 0.005 mg per gram of feed, thereby obtaining the ganoderma acid A-containing feed. ...

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Abstract

The invention discloses the application of ganoderma acid A and its derivatives or ganoderma total triterpenes in the preparation of medicines for treating eye diseases. Drugs or functional products composed of ganoderma acid A or its derivatives or ganoderma triterpenoids can significantly reduce lacrimal gland and corneal lesions in naturally aging mice, and the body's metabolism level is closer to the youthful state, and can prevent cataracts and eye degeneration Sexual lesions and other eye diseases, the effect is clear, and the safety is high.

Description

Technical field: [0001] The invention belongs to the field of biomedicine, and specifically relates to the application of ganoderma acid A and its derivatives or ganoderma total triterpenes in the preparation of medicines for treating eye diseases. Background technique: [0002] Ganoderma lucidum is the dry fruiting body of Ganoderma lucidum (Leyss.ex Fr.) Karst. or Ganoderma sinense Zhao, Xu et Zhang of Polyporaceae. Lung deficiency cough and asthma, fatigue and shortness of breath, not thinking about eating and drinking embolism. In my country, Ganoderma lucidum has been used medicinally for 2,000 years. "Shen Nong's Materia Medica" lists Ganoderma lucidum as the top grade, which has the effects of calming the nerves, improving sleep, and benefiting essence. Pharmacological studies have shown that Ganoderma lucidum triterpenes and polysaccharides are the two main pharmacologically active components of Ganoderma lucidum. Ganoderic acid and ganoderma enoic acid are a class ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/575A61K36/074A61P27/02A61P27/12
CPCA61K31/575A61K36/074A61P27/02A61P27/12
Inventor 王东东陈地灵郭殷锐祁龙凯唐晓萃谢意珍李良秋吴清平
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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