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Drug composition for treating or inhibiting solid tumor and drug box containing composition

A composition and drug technology, applied in the field of anti-solid tumors, to achieve the effects of effective treatment, high effectiveness, and controllable preparation

Inactive Publication Date: 2021-02-02
CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thus, there is still a need to develop new immunization strategies to meet urgent clinical needs that cannot be met by existing technologies

Method used

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  • Drug composition for treating or inhibiting solid tumor and drug box containing composition
  • Drug composition for treating or inhibiting solid tumor and drug box containing composition
  • Drug composition for treating or inhibiting solid tumor and drug box containing composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0172] Example 1: Preparation of the graft

[0173] In the following examples, the tissues used are selected from one or more of the following groups: 1) natural tissues extracted from animals. Such as muscle, blood, spinal cord; 2) animal natural tissue components containing cells and intercellular matrix. For example, cell-enriched components of animal natural tissues (such as blood) (such as blood cells to concentrate blood); 3) engineered tissues derived from natural tissues containing cells and intercellular matrix.

[0174] In the following examples, the cell preparations used are selected from one or more of natural cell preparations and / or engineered cells derived from connective tissue and / or semi-solid tissues other than connective tissue. For example, white blood cell pellets, red blood cell pellets, and platelet pellets are obtained from natural blood separations according to the prior art. Another example is to extract and prepare hematopoietic stem cells from t...

Embodiment 1a

[0195] Example 1a: 20 g of porcine spinal cord tissue obtained from membrane-containing porcine spinal cord tissue extraction (puncture extraction or dissection to remove the outer membrane), is the injectable semi-fluid preparation X1 in the above table.

[0196] If X1 is placed in a cup with a breathable lid and steamed in steam (about 100°C) for 30 minutes, the preparation X2 in the above table can be obtained.

Embodiment 1b

[0197] Embodiment 1b: 20g of lean meat pieces from mice are extracted through tissue (stripping off fat, membranes, tendons, blood vessels), and the muscle tissue of the mice obtained is a semi-solid tissue, which is then placed in a blender to break (rotating speed 3000-10000 rev / min, total time 1-3 minutes), just obtain the muscle tissue granule (preparation X5 in the above table) that the cross-sectional average size is less than 1mm×1mm, discernible by naked eyes. The rotational speed and time of shearing and crushing can be set such that the cross-sectional average size of the particles obtained is ≥ 100 nm, preferably 500 nm-0.8 mm or 1 μm-0.8 mm. Preparation X5 deforms irreversibly under pressure and is semifluid.

[0198] If X5 is further placed in a cup with a breathable lid, steamed in steam (about 100°C) for 10 minutes, the preparation X6 in the above table can be obtained.

[0199] If X5 is further placed in a plastic bag and sealed, placed in liquid nitrogen (low...

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Abstract

The invention relates to a drug composition for treating or inhibiting solid tumor, a drug box containing the composition and an anti-solid tumor method. The drug composition includes a graft outsidetumor and an anti-transplantation drug for genetically identical tumor transplantation.

Description

technical field [0001] The present invention relates to a drug combination for treating or inhibiting solid tumors, a medicine box containing the combination, and a method for fighting solid tumors. Background technique [0002] Various substances have been used to make tumor vaccines. Microbial substances were first used in the development of solid tumor vaccines. As early as 1891, William B. Coley (William B. Coley) discovered that the inactivated Streptococcus pyogenes and Serratia marcescens (Coley toxin) had curative effect on certain tumors. Bacillus Calmette-Guerin (BCG) has a similar effect. Since then, researchers have found that live, attenuated or genetically modified obligate or facultative anaerobic bacteria (such as Clostridium, Salmonella, Bifidobacterium, and Escherichia) can release certain Antigens activate the body's immune system and can also selectively multiply within tumors (can be used as colonization vectors). At the latest in 1912, another resea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K39/00A61P35/00A61P37/06
CPCA61K39/0011A61K45/06A61P35/00A61P37/06A61K2300/00
Inventor 邹方霖邹礼常王建霞王艺羲
Owner CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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