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Preparation method and application of core-shell structure microcapsule particles

A core-shell structure and microcapsule technology is applied in the field of preparation of core-shell structure microcapsule particles, which can solve the problems of difficulty in assembly and single shape of the microcapsule, and achieve the effects of good digestion effect, slow digestion effect and application prospect improvement.

Active Publication Date: 2021-02-02
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hydrophilic-hydrophobic core-shell structure microcapsules can further enrich and enhance the functional properties of microcapsules by integrating the hydrophilic and hydrophobic characteristics of the two materials inside and outside, and regulating the shape of the microcapsules. The opposite sex makes it difficult to assemble, and the shape of the microcapsule is relatively simple

Method used

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  • Preparation method and application of core-shell structure microcapsule particles
  • Preparation method and application of core-shell structure microcapsule particles
  • Preparation method and application of core-shell structure microcapsule particles

Examples

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Embodiment 1

[0038]Example 1: Preparation of spherical hydrophilic-hydrophobic core-shell microcapsule particles.

[0039] 1) Preparation of hydrophilic nucleosome gel particles: prepare 100 g (1% w / w) of sodium alginate solution with ultrapure water (the concentration of sodium alginate can be 1-3% (w / w), the present embodiment Preferred 1% (w / w)) and calcium chloride solution 200g (5% w / w) (the concentration of calcium chloride solution can be 5-10% (w / w), the preferred 5% (w / w) of present embodiment w)), and adjust the pH of the prepared sodium alginate and calcium chloride solution to 4 (the pH range can be 3-5, preferably 4 in this embodiment). Draw the sodium alginate solution through a syringe (the needle diameter is 0.19mm, 0.3mm, 0.45mm, 0.6mm and 1.2mm), and drop it drop by drop at 0.3mL / min at a distance of 5cm from the surface of the 5% (w / w) calcium chloride solution , standing still for 30 minutes to prepare spherical hydrophilic nucleosome gel particles of different sizes. ...

Embodiment 2

[0043] Example 2: Preparation of ellipsoidal hydrophilic-hydrophobic core-shell microcapsule particles.

[0044] 1) Preparation of hydrophilic nucleosome gel particles: prepare 100 g (1% w / w) of sodium alginate solution with ultrapure water (the concentration of sodium alginate can be 1-3% (w / w), the present embodiment Preferred 1% (w / w)), high concentration calcium chloride solution 200g (5% w / w) (the concentration of calcium chloride solution can be 5-10% (w / w), the preferred 5% of the present embodiment ( w / w)) and low concentration calcium chloride solution 200g (0.2%w / w) (the concentration of calcium chloride solution can be 0.1-0.3% (w / w), the preferred 0.2% (w / w) of the present embodiment ), and the pH of the prepared sodium alginate and calcium chloride solution is adjusted to 4 (the pH range can be 3-5, preferably 4 in this embodiment). Draw the sodium alginate solution through a syringe (needle diameters of 0.19mm, 0.3mm, 0.45mm, 0.6mm and 1.2mm), drop in 0.2% (w / w)...

Embodiment 3

[0047] Example 3: Preparation of fibrous hydrophilic-hydrophobic core-shell microcapsule particles.

[0048] 1) Preparation of hydrophilic nucleosome gel particles: prepare 100 g (1% w / w) of sodium alginate solution with ultrapure water (the concentration of sodium alginate can be 1-3% (w / w), the present embodiment Preferred 1% (w / w)) and calcium chloride solution 200g (5% w / w) (the concentration of calcium chloride solution can be 5-10% (w / w), the preferred 5% (w / w) of present embodiment w)), and adjust the pH of the prepared sodium alginate and calcium chloride solution to 4 (the pH range can be 3-5, preferably 4 in this embodiment). Draw the sodium alginate solution through a syringe (needle diameters of 0.6mm, 0.7mm, 0.8mm, 0.9mm and 1.2mm), and extend it into the 5% (w / w) calcium chloride solution below the liquid surface for continuous extrusion. Let stand for 30min to prepare fibrous hydrophilic nucleosome gel particles of different sizes. The first row and the first ...

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Abstract

The invention relates to the technical field of core-shell structure microcapsule particle preparation, in particular to a preparation method and application of core-shell structure microcapsule particles, and the preparation method comprises the following steps of: (1) taking a sodium alginate solution with a certain pH and a certain mass concentration as a water phase, dropwise adding the sodiumalginate solution into a Ca<2+> solution with a certain concentration, and performing curing to form gel particles; and (2) adding the obtained gel particles into an ethanol aqueous solution of zeinwith a certain pH value and a certain mass concentration while stirring, separating out the zein, adsorbing the zein on the surfaces of the gel particles to form shells, and finally forming core-shellstructure microcapsule particles taking the zein as a shell layer and adopting gel particles as the core body. The shape-adjustable hydrophilic and hydrophobic core-shell structure microcapsule particles are prepared on the basis of an electrostatic interaction principle, so that the microcapsule has the common characteristics of a hydrophilic material and a hydrophobic material, has a better digestion slowing effect on embedded grease, and has a better slow-release effect on embedded functional factors.

Description

technical field [0001] The invention relates to the technical field of preparation of core-shell structure microcapsule particles, in particular to a preparation method and application of core-shell structure microcapsule particles. Background technique [0002] In the industrial production of food, medicine and biomedicine, microcapsules are widely used as an encapsulation technology. Hydrophilic-hydrophobic core-shell structure microcapsules can further enrich and enhance the functional properties of microcapsules by integrating the hydrophilic and hydrophobic characteristics of the two materials inside and outside, and regulating the shape of the microcapsules. The heterosexuality makes it difficult to assemble, and the shape of the microcapsule is relatively simple. [0003] Sodium alginate is a natural source of anionic polymeric polysaccharides. Due to factors such as easy extraction and low cost, it is widely used in the food industry and pharmaceutical fields. Sod...

Claims

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Application Information

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IPC IPC(8): B01J13/02
CPCB01J13/02
Inventor 方亚鹏张讯胡冰麻瑞祥杨易俗
Owner HUBEI UNIV OF TECH
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