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Medical application of Sishen pill or extract thereof

A technology of extract and use, applied in the field of medical application of Sishen Pill or its extract, to achieve the effect of preventing or treating insomnia

Pending Publication Date: 2021-02-09
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sedative-hypnotic effect and sleep structure regulation effect of Sishen Pill have not been reported yet

Method used

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  • Medical application of Sishen pill or extract thereof
  • Medical application of Sishen pill or extract thereof
  • Medical application of Sishen pill or extract thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1: the preparation of this traditional Chinese medicine combination alcohol extract

[0060] (1) Nutmeg, fortified with the weight ratio (2 parts by weight of nutmeg, 4 parts by weight of psoralen, 2 parts by weight of Schisandra chinensis, 1 part by weight of Evodia rutaecarpa, 2 parts by weight of Chinese jujube, and 2 parts by weight of ginger). Add 10 times the amount of bone fat, schisandra, evodia, jujube, and ginger (add 1ml ethanol per gram of medicinal materials), heat 70% (weight ratio) ethanol (until the ethanol boils) and reflux for 2 hours, filter, and concentrate the filtrate to a thick paste for later use ;

[0061] (2) Continue to add 10 times the amount of water to decoct the dregs for 2 times, each time for 1 hour, filter, and concentrate the filtrate to a thick paste;

[0062] (3) The water-extracted thick paste of step (2) is combined with the alcohol-extracted thick paste in step (1), and mixed to obtain an extract containing 1.26g cru...

Embodiment 2

[0063] Embodiment 2: the sedative-hypnotic effect of Sishen Wan extract

[0064] 1. The effect of Sishen Pill extract synergistically with pentobarbital sodium on righting reflex in mice.

[0065] Experimental animals: ICR mice, male, SPF grade, 22-25 g, purchased from Speiford (Beijing) Experimental Animal Co., Ltd.

[0066] Test sample: the prepared Sishen Pill extract, according to the extraction rate and the dosage of medicinal materials, weigh the corresponding quality of the extract, add normal saline to make a suspension, and give it to the stomach.

[0067] Experimental method: The mice were adaptively fed for one week after purchase, and were randomly divided into 4 groups according to body weight, 10 mice in each group, which were solvent control group (vehicle, normal saline), low dose of Sishen Pill (based on crude drug quality, 5.55 g / kg) group, Sishen Pill medium dose (based on crude drug quality, 11.09g / kg) group and Sishen Pill high dose (based on crude drug...

Embodiment 3

[0087] Embodiment 3: The insomnia intervention effect of Sishen pill extract on PCPA model

[0088] Experimental animals: ICR mice, male, SPF grade, 22-25 g, purchased from Speiford (Beijing) Experimental Animal Co., Ltd.

[0089] Test sample: the prepared Sishen Pill extract, according to the extraction rate and the dosage of medicinal materials, weigh the corresponding quality of the extract, add normal saline to make a suspension, and give it to the stomach. Diazepam was converted into the dosage for mice according to the clinical dosage, and the corresponding mass of solid was weighed to make a physiological saline solution for intraperitoneal injection.

[0090]Experimental method: The mice were adaptively fed for one week after purchase, and were randomly divided into 6 groups according to body weight, 10 mice in each group, which were solvent control group (vehicle, normal saline), positive control group (diazepam 3 mg / kg, i.p. ), PCPA model group (400mg / kg, i.p.), S...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to medical application of a Sishen pill or an extract thereof. Specifically, the medical application is application ofany one selected from the following (1) and (3) in preparation of medicines for sedation and hypnosis, treatment or prevention of insomnia, anti-anxiety, or sleep regulation: (1) a pharmaceutical composition comprising myristica fragrans, fructus psoraleae, schisandra chinensis, fructus evodiae, Chinese dates and fresh ginger; (2) an extract which is an aqueous extract and / or an ethanol extract ofthe pharmaceutical composition in the (1); and (3) a pharmaceutical preparation comprising the extract in the (2) and one or more pharmaceutically acceptable auxiliary materials. The pharmaceutical composition, the extract or the pharmaceutical preparation has good effects in sedation and hypnosis, treatment or prevention of insomnia, or sleep regulation.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to the medical application of Sishen pill or its extract. Specifically, the use is sedative hypnosis, prevention or treatment of insomnia or sleep regulation. Background technique [0002] Insomnia refers to a neuropsychiatric disease that occurs when sleep time is sufficient and the environment is suitable, and it is difficult to fall asleep or maintain sleep, which leads to daytime dysfunction. The main symptoms are difficulty falling asleep, frequent awakening, early awakening and non-restorative sleep. Insomnia is the most common sleep disorder, and the incidence rate of short-term insomnia can reach 30% to 50%. In the world's major industrial countries, chronic insomnia patients account for at least 5% to 10% of the total population, and 5% to 7% of people have been or are currently Prescription drugs are used to treat insomnia. According to the epidemiological survey o...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K31/5513A61K31/519A61K31/4985A61K9/20A61P25/20A61P25/22
CPCA61K36/185A61K36/487A61K36/79A61K36/57A61K36/754A61K36/725A61K36/9068A61K31/5513A61K31/519A61K31/4985A61K9/20A61P25/20A61P25/22A61K2236/333A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 张有志李劲草薛瑞张杨王洛萱李迎李硕董华进
Owner ACADEMY OF MILITARY MEDICAL SCI
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