Synthetic method of methyl salicylate

Abstract

The invention discloses a synthesis method of methyl salicylate. The method comprises the following steps: preparing sodium phenolate by using caustic soda flakes and phenol as raw materials, carryingout carboxylation reaction on the obtained sodium phenolate and carbon dioxide gas to obtain sodium salicylate, reacting the obtained sodium salicylate with chloromethane gas under the action of a phase transfer catalyst to obtain a crude methyl salicylate product containing a toluene solvent, neutralizing and washing the crude methyl salicylate product, recovering the toluene solvent at normal pressure, and carrying out vacuum distillation to obtain a finished methyl salicylate product. According to the method, a strong acid catalyst is not used, so that the wastewater amount is greatly reduced, and the corrosion to equipment and the pollution to the environment are reduced. According to the method, equipment is not seriously corroded, the wastewater amount is small, and the process is more environmentally friendly.

Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, in particular to a method for synthesizing methyl salicylate. Background technique

[0002] Methyl salicylate, the chemical name is methyl o-hydroxybenzoate, also known as wintergreen oil, methyl salicylate. Appearance is colorless oily liquid with sweet, wintergreen characteristic aroma and taste. Molecular formula is C 8 h 8 o 3 , the molecular weight is 152.15, the melting point is -8°C, and the boiling point at normal pressure is 222°C. It is soluble in organic solvents such as alcohol and ether, and almost insoluble in water. Methyl salicylate occurs naturally in wintergreen, birch, tuberose, carnation, tomato, cherry, strawberry. As a fragrance, methyl salicylate is widely used in daily flavors such as acacia, tuberose, ylang-ylang, sucrose, and gardenia, especially in toothpaste and oral cleansers, and also used in strawberries, grapes, In food flavors such as vanilla; as m...