A kind of polyvinyl alcohol-based hydrogel film and preparation method thereof
A technology based on polyvinyl alcohol and polyvinyl alcohol, applied in the field of polyvinyl alcohol-based hydrogel film and its preparation, can solve the problems of affecting the mechanical properties of materials, unstable antibacterial effect, short antibacterial validity period, etc.
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[0030] The invention provides a kind of preparation method of polyvinyl alcohol-based hydrogel film, comprising the following steps:
[0031] a) under the action of catalyst, polyvinyl alcohol and succinic anhydride react to form succinic anhydride modified polyvinyl alcohol;
[0032] b) activating the succinic anhydride-modified polyvinyl alcohol by mixing with a catalyst and an acid solution to obtain an activation solution;
[0033] c) mixing and reacting the activation solution with polyhexamethylene monoguanidine to form polyhexamethylene monoguanidine cross-linked polyvinyl alcohol colloid solution;
[0034] d) Swelling the polyhexamethylene monoguanidine cross-linked polyvinyl alcohol colloid solution to form a film to obtain a polyvinyl alcohol-based hydrogel film.
[0035] In the present invention, polyvinyl alcohol is first reacted with succinic anhydride to obtain polyvinyl alcohol modified with succinic anhydride, a part of the side chain has carboxyl groups, and ...
Embodiment 1
[0061] 1.1 Preparation
[0062] S1. Take 20mL of DMSO after dehydration and add it to a two-necked flask, then add 1g of PVA, dissolve at 100°C for 3h; then cool down to 30°C, add 200μL of triethanolamine and 0.15g of succinic anhydride, and react under stirring 12h.
[0063] S2. Add 0.1 g of EDC and NHS (the mass ratio of the two is 1:1), 1 mL of nitric acid solution (concentration: 0.01 M) to the system after the reaction in step S1, and continue to activate at 30° C. for 1 hour to form an activation solution.
[0064] S3. Keeping at 30° C., add 0.05 g of PHMG to the activation solution to continue the reaction for 6 hours to form polyhexamethylene monoguanidine cross-linked polyvinyl alcohol colloid solution.
[0065] S4. Pour the obtained solution evenly into a petri dish (diameter 6cm), the volume of the solution poured into the petri dish is 10mL, and then place it in a 60°C oven to dry for 24h; after taking it out, add deionized water to fully swell, and peel off the s...
Embodiment 2
[0073] 1.1 Preparation
[0074] S1. Take 20 mL of DMSO after water removal and add it to a two-necked flask, then add 1 g of PVA, dissolve at 100°C for 3 hours; then cool down to 30°C, add 200 μL of triethanolamine and 0.2 g of succinic anhydride, and react under stirring conditions 12h.
[0075] S2. Add 0.1 g of EDC and NHS (the mass ratio of the two is 1:1), 1 mL of nitric acid solution (concentration: 0.01 M) to the system after the reaction in step S1, and continue to activate at 30° C. for 1 hour to form an activation solution.
[0076] S3. Keeping at 30° C., add 0.1 g PHMG to the activation solution to continue the reaction for 6 hours to form polyhexamethylene monoguanidine cross-linked polyvinyl alcohol colloid solution.
[0077] S4. Pour the obtained solution evenly into a petri dish (diameter 6cm), the volume of the solution poured into the petri dish is 10mL, and then place it in a 60°C oven to dry for 24h; after taking it out, add deionized water to fully swell, a...
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