Micro-liquid node surface extractant and application thereof in surface extraction and mass spectrometry of photoinitiator sample of cigarette material

A technology of photoinitiator and extraction agent, applied in the field of mass spectrometry detection pretreatment, to reduce false negatives, improve universality and detection rate, and avoid false negatives

Pending Publication Date: 2021-02-12
CHINA TOBACCO HUNAN INDAL CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no method for rapid sampling and detection of photoinitiators in smoking materials using micro-liquid junction mass spectrometry

Method used

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  • Micro-liquid node surface extractant and application thereof in surface extraction and mass spectrometry of photoinitiator sample of cigarette material
  • Micro-liquid node surface extractant and application thereof in surface extraction and mass spectrometry of photoinitiator sample of cigarette material
  • Micro-liquid node surface extractant and application thereof in surface extraction and mass spectrometry of photoinitiator sample of cigarette material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] The optimum extraction solvent composition was determined by condition screening experiments. The specific steps are as follows:

[0077] (1) Extraction solvent preparation: prepare 50% acetonitrile water, 70% acetonitrile water and 90% acetonitrile water respectively. Additive selection 0.1%, 0.5% toluene, 0.1%, 0.5%, 1% acetic acid, 0.1%, 0.5%, 1% benzoic acid

[0078] (2) Production of simulated paper: add a certain concentration of photoinitiator to the ink without photoinitiator, and use a wire bar coater to coat the paper, based on the area coated, the amount of ink used, and the amount added to the standard sample The content of photoinitiator in the simulated paper can be calculated (mg / m 2 ).

[0079] (4) Microfluidic node scanning of simulated paper under different solvent conditions: the simulated paper was placed on a three-axis platform and fixed in a single-point extraction mode. The syringe pump pumps the extract into the probe at a rate of 5 μL / min. ...

Embodiment 2

[0083] Detection of Photoinitiators in Quantitative Gradient Spiked Mimic Paper Using Microliquid Junction Mass Spectrometry. The specific steps are as follows:

[0084] (1) Production of simulated paper: add a photoinitiator with a certain concentration gradient to the ink without photoinitiator, use a wire bar coater to coat the paper, and use the coated area, the amount of ink and the amount added by the standard sample The amount can be calculated to simulate the content of photoinitiator in the paper (mg / m 2 ) are 0.4, 2, 6.64, 13.3 respectively.

[0085] (2) Scanning of simulated paper microfluidic nodes: place the simulated paper on a three-axis platform and fix it. The microfluidic junction probe scans the selected rectangular area in zigzag at a speed of 500 μm / s. At the same time, the syringe pump pumped the extraction solution (0.5% acetic acid-90% acetonitrile-water) onto the probe at a speed of 10 μL / min. The extract is drawn into the quantitative loop by the ...

Embodiment 3

[0094] Real samples were detected by microliquid junction mass spectrometry. The specific steps are as follows:

[0095] (1) Actual sample: The actual sample for this test is a cigarette case of a certain brand.

[0096] (2) Scanning of simulated paper microfluidic nodes: place the simulated paper on a three-axis platform and fix it. The microfluidic junction probe scans the selected rectangular area in zigzag at a speed of 500 μm / s. At the same time, the syringe pump pumped the extract solution (0.5% acetic acid-90% acetonitrile water) to the probe at a speed of 10 μL / min. The extract is drawn into the quantitative loop by the vacuum pump.

[0097] (3) On-line mass spectrometry detection of the photoinitiator: After the probe scans for 1 min, the six-way valve switches the valve position so that the liquid phase pump pushes the analyte in the quantitative loop into the mass spectrometer for detection. At the same time the probe stops scanning. The detection condition of ...

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Abstract

The invention belongs to the technical field of detection, and particularly discloses a photoinitiator micro-liquid node surface extractant which comprises 0.1-5 v% of acetic acid, 5-9.9 v% of water and the balance of acetonitrile. The invention also discloses a method and a system for carrying out surface sampling (surface extraction) on a cigarette sample by using the surface extraction agent, and also comprises a method and a system for obtaining a sample to be detected by using the surface sampling method and carrying out mass spectrometric determination. According to the method, in-situ real-time detection of the photoinitiator in the cigarette material is realized, the problems that the photoinitiator detection treatment process in the existing cigarette material is complicated, thedetection time is long and a large amount of solvent is consumed are solved, and the method has huge advantages in detection efficiency, accuracy and environmental protection.

Description

technical field [0001] The invention belongs to the field of pretreatment for mass spectrometry detection, and in particular relates to a method for rapid sampling and detection of photoinitiators in smoking materials. Background technique [0002] In recent years, UV printing has been widely used in the printing of tobacco materials due to its outstanding advantages. The photoinitiator used is a class of compounds that can absorb light in the ultraviolet band and generate free radicals or cations to initiate polymerization and curing reactions. It is the main component of UV inks, UV glues and UV coatings. Studies have shown that after the photocuring reaction is completed, the residual initiators, especially some initiators with smaller molecular weights, will migrate under certain conditions, and will pose a threat to human health when in contact with people, such as carcinogenic, carcinogenic sensitization and reproductive toxicity. [0003] Standard photoinitiator det...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/40G01N27/62
CPCG01N1/4055G01N27/62G01N2001/4061
Inventor 梁秋菊梅雨王志国吴倩周世文刘巍杜文
Owner CHINA TOBACCO HUNAN INDAL CORP
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