Composite pipe as well as preparation method and application thereof

A composite tube and composite sheet technology, applied in the field of medical materials, can solve problems such as the release time only covering one to three months, the metabolism of degradation products, and the increase in the amount of materials, so as to achieve lightweight, reduce metabolic burden, prevent mutual influence

Active Publication Date: 2021-02-19
SHANDONG HUAAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the degradable tubular stent with a three-dimensional textile structure has a large number of stent rods, which leads to an increase in the amount of materials used. During the degradation process of the degradable tubular stent, a large number of degradation products will be produced, and the tissue cannot completely degrade these in a short time. Metabolism of products, which may cause intestinal re-infarction
In addition, the release time of the outer drug film layer can only cover one to three months, and most of the drugs are released within one month after implantation, especially there will be a burst release period within one or two weeks after implantation , after one year of implantation, it is difficult to have effective drugs to play a role in the patient's body

Method used

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  • Composite pipe as well as preparation method and application thereof
  • Composite pipe as well as preparation method and application thereof
  • Composite pipe as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0128] A composite pipe comprising three orientation layers and two drug-carrying layers, the orientation layers and the drug-carrying layers are arranged alternately, and the innermost and outermost layers of the pipe wall of the composite pipe are both orientation layers; each orientation layer The number of orientation directions is one, and each orientation layer is composed of a single-layer orientation film prepared from a uniaxially stretched film material (polylactic acid (PLLA) film material); The drug layer contains polycaprolactone and rapamycin, and the drug-carrying layer near the inner side of the tube wall of the composite tube contains polycaprolactone and sodium bicarbonate; the wall thickness of the composite tube is 0.06mm, and the drug-carrying amount of the composite tube is Rapamycin 1.5mg / g, sodium bicarbonate 0.5mg / g.

[0129] Its specific preparation method is as follows:

[0130] (1) 100g polycaprolactone is mixed with 0.5g sodium bicarbonate to obta...

Embodiment 2

[0135] A composite pipe comprising three orientation layers and two drug-carrying layers, the orientation layers and the drug-carrying layers are arranged alternately, and the innermost and outermost layers of the pipe wall of the composite pipe are both orientation layers; each orientation layer The number of orientation directions is one, and each orientation layer is made of a single-layer orientation film prepared by a uniaxially stretched film material (PLLA film material); Lactone and rapamycin, the drug-carrying layer near the inner side of the tube wall of the composite tube contains polycaprolactone and sodium bicarbonate; the wall thickness of the composite tube is 0.06mm, and the drug-carrying amount of the composite tube is 1.5% rapamycin mg / g, sodium bicarbonate 0.5mg / g.

[0136] The only difference between the preparation method and Example 1 is that in step (2), the superimposition of the orientation layers adopts alignment and superposition, so that the number ...

Embodiment 3

[0138] A composite pipe comprising three orientation layers and two drug-carrying layers, the orientation layers and the drug-carrying layers are arranged alternately, and the innermost and outermost layers of the pipe wall of the composite pipe are both orientation layers; each orientation layer The number of orientation directions is one, and each orientation layer is made of a single-layer orientation film prepared by a uniaxially stretched film material (PLLA film material); Lactone and rapamycin, the drug-carrying layer near the inner side of the tube wall of the composite tube contains polycaprolactone and sodium bicarbonate; the wall thickness of the composite tube is 0.05mm, and the drug-carrying amount of the composite tube is 1.5% rapamycin mg / g, sodium bicarbonate 0.5mg / g.

[0139] The only difference between the preparation method and Example 1 is that in step (4), it also includes applying a pulling force of 3N / mm to the two ends of the nascent composite pipe 2 T...

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Abstract

The invention provides a composite pipe as well as a preparation method and application thereof. The pipe wall of the composite pipe comprises at least two orientation layers and at least two medicine-carried layers, the orientation layers and the medicine-carried layers are alternately arranged, the innermost layer of the pipe wall is the orientation layer, the outermost layer of the pipe wall isthe orientation layer or the medicine-carried layer, the orientation layers comprise orientation films, and the medicine-carried layers comprise first binders and medicine. According to the compositepipe, the orientation layers and the medicine-carried layers are alternately arranged, so that on one hand, the medicine-carried layers are separated, and on the other hand, the release speed of themedicine is effectively controlled; and the composite pipe has excellent biocompatibility and degradability, has the advantages that the supporting force is strong, the medicine release speed is adjustable, and the like, and has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a composite pipe and its preparation method and application. Background technique [0002] Interventional medical engineering refers to medical engineering technology that uses interventional devices, interventional materials and modern digital diagnostic equipment for diagnosis and treatment operations. [0003] Stent surgery as an interventional surgery has been clinically implemented for many years. With the development of science and technology and the improvement of people's requirements for quality of life, stent products made of new bioabsorbable materials have come out and are being used in clinical practice one after another. Compared with traditional non-absorbable metal stents, bioabsorbable materials can be gradually absorbed by human tissue after completing the supporting mission, which fundamentally avoids the late risk of permanent implantati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M25/00A61L29/08A61L29/14
CPCA61M25/0045A61M25/0009A61L29/085A61L29/148A61M2025/0056
Inventor 穆云泓魏征
Owner SHANDONG HUAAN BIOTECH CO LTD
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