Water-soluble tilmicosin premix and preparation method thereof

A technology of tilmicosin and premix, which is applied in medical formulas, organic active ingredients, medical preparations of non-effective ingredients, etc., and can solve problems such as difficult feeding for farmers, poor feeding effect, and difficult operation , to achieve the effects of less water content, improved solubility and high bioavailability

Inactive Publication Date: 2021-03-23
江西邦诚动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing tilmicosin mixture has a bitter taste, and the feeding effect is not good, and its existing products have poor water solubility and need to be fed directly. The operation is difficult and extremely inconvenient, which brings inconvenience to the current farmers when feeding. great difficulty

Method used

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  • Water-soluble tilmicosin premix and preparation method thereof
  • Water-soluble tilmicosin premix and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0024] A taste-masking water-soluble synergistic tilmicosin premix, which consists of the following components by weight: 22 parts of tilmicosin, 20 parts of polyethylene glycol, 40 parts of anhydrous glucose, hydroxypropyl methyl Cellulose phthalate 18 parts.

[0025] The specific operation steps are:

[0026] (1) 20 parts of polyethylene glycol and 18 parts of hydroxypropyl methylcellulose phthalate are added to 40 parts of ethanol to fully dissolve the polyethylene glycol and hydroxypropyl methylcellulose phthalate, and then heated to 60 ℃ to make it completely dissolved;

[0027] (2) Add 22 parts of tilmicosin while stirring, and stir to dissolve completely;

[0028] (3) Add 40 parts of anhydrous glucose and stir well;

[0029] (4) be placed in the hot air circulating oven of 55 ℃ and dry;

[0030] (5) Pass through an 80-mesh sieve after crushing.

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Abstract

The invention provides a water-soluble tilmicosin premix and a preparation method thereof. The premix is characterized by comprising the following components of tilmicosin, a taste masking agent, a medicinal filling auxiliary material and a coating material. The preparation method comprises the following steps of 1, adding the taste masking agent and the coating material into a cosolvent, and performing stirring dissolving; 2, adding the tilmicosin, and performing stirring dissolving; and 3, performing drying to obtain the tilmicosin premix. According to the premix and the method, the limitation of the masking effect of a traditional taste masking process is solved, and the specific bitter taste of the tilmicosin is effectively masked so that the palatability of animals can be improved; and the solubility of the tilmicosin in water is improved, and the animals can eat medicines by drinking water, so that the premix is popular among a large number of farmers.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, in particular to a water-soluble tilmicosin premix and a preparation method thereof. Background technique [0002] In the prior art, it is an over-the-counter drug. It is a semi-synthesized antibiotic for livestock and poultry from a hydrolyzate of tylosin, and its phosphate is used for medicine. The existing tilmicosin mixture has a bitter taste, and the feeding effect is not good, and its existing products have poor water solubility and need to be fed directly. The operation is difficult and extremely inconvenient, which brings inconvenience to the current farmers when feeding. great difficulty. Contents of the invention [0003] In view of this, the present invention aims to propose a water-soluble tilmicosin premix and preparation method thereof, which solves the limitations of traditional bitterness masking technology masking effect, can improve the palatability of animals, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/706A61K47/32A61K47/10A61P31/04
CPCA61K31/706A61K9/146A61P31/04
Inventor 夏振波
Owner 江西邦诚动物药业有限公司
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