Traditional Chinese medicine composition for assisting ovarian cancer treatment, preparation and preparation method

A composition and ovarian cancer technology, applied in the field of medicine, can solve problems such as severe radiation reactions, concurrent infections, and decreased immunity, and achieve the effects of enhanced curative effect, reasonable process, and strong process innovation

Inactive Publication Date: 2021-04-09
JIANGSU ZHENGYANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Further control the survival rate of tumor cells by increasing the local radiation dose, but it will cause more serious radiation reactions, especially acute radiation reactions, such as decreased immunity, concurrent infection, nausea and vomiting, and more serious systemic reactions

Method used

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  • Traditional Chinese medicine composition for assisting ovarian cancer treatment, preparation and preparation method
  • Traditional Chinese medicine composition for assisting ovarian cancer treatment, preparation and preparation method
  • Traditional Chinese medicine composition for assisting ovarian cancer treatment, preparation and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Process optimization of traditional Chinese medicine granules for adjuvant treatment of ovarian cancer

[0021] 1. Sample preparation

[0022] Scheme 1: Step 1, weigh 15 parts of Guizhi decoction pieces according to the parts by weight, add 20 times the volume of purified water according to the weight-to-volume ratio, extract by steam distillation for 1 hour, and collect the aromatic water; Step 2, according to the parts by weight Weigh the decoction pieces of Smilax smilax, Fotanmu, and Commelina chinensis, add cinnamon twig dregs and liquid medicine in step 1, add 10 times the volume of purified water according to 45 parts of Smilax smilax, 15 parts of Fotanmu, and 15 parts of Commelina chinensis, Reflux extraction 2 times, 1 hour each time, extract, filter, combine to obtain the total extract; step 3, take the aromatic water in step 1 and combine the total extract in step 2, add 5 parts of cyclodextrin, stir Suspended, separated by a nanofiltration membrane with a m...

Embodiment 2

[0037] Embodiment 2 Granules

[0038] Step 1: Take 15 parts by weight of Guizhi decoction pieces, add 20 times the volume of purified water according to the weight-to-volume ratio, extract by steam distillation for 1 hour, and collect the aromatic water; Step 2: Take the soil according to the parts by weight Poria cocos, fotanmu, and commelina decoction pieces, add cinnamon twig dregs and liquid medicine in step 1, add 10 times the volume of purified water to extract 2 Each time, 1 hour each time, extract, filter, and combine to obtain the total extract; Step 3: Take the total extract of step 2, adjust the pH of the solution to 3.0, and refine it by polyamide resin adsorption. After the sample is loaded, use step 1 Elute with aromatic water, then 2 times the column volume of purified water, then elute with 75% ethanol for 6 times the column volume, and collect the eluate; step 4: take the eluate in step 3 and add 5 parts of cyclopaste Refined, stirred and suspended, separated...

Embodiment 3

[0039] Example 3 tablet

[0040] Step 1: Take 10 parts by weight of Guizhi decoction pieces, add 20 times the volume of purified water according to the weight-to-volume ratio, extract by steam distillation for 1 hour, and collect the aromatic water; Step 2: Take the soil according to the number of parts by weight Poria cocos, fotanmu, and commelina decoction pieces, add cinnamon twig dregs and liquid medicine in step 1, add 10 times the volume of purified water according to 47 parts of smilax, 18 parts of fotanmu, and 15 parts of commelina, and reflux to extract 2 1 hour each time, the extract was filtered and combined to obtain the total extract; step 3: take the total extract of step 2, adjust the pH of the solution to 2.0, and refine it by adsorption of AB8 macroporous resin. After the sample loading is completed, use the step 1 elution with aromatic water, followed by elution with 2 times column volume of purified water, and then 4 times column volume with 70% ethanol to c...

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Abstract

The invention belongs to the technical field of medicines, and relates to a traditional Chinese medicine composition for assisting ovarian cancer treatment, a preparation and a preparation method. The traditional Chinese medicine composition is prepared from extracts of crude drugs, by weight, 30-60 parts of rhizoma smilacis glabrae, 10-20 parts of polygonum chinense, 10-20 parts of dayflower and 10-20 parts of cassia twigs. Refining is conducted by extracting aromatic water and water decoction through resin adsorption, eluent cyclodextrin inclusion is conducted, an intermediate extract is prepared by combining nanofiltration concentration and spray drying technologies, and auxiliary materials are added to prepare granules, tablets, capsules, vaginal effervescent tablets and suppositories. According to the composition, a preparation process is optimized according to the thermal stability and volatility of the medicinal components, so that the conversion of heat-sensitive components and the loss of volatile components are effectively avoided, the process innovativeness is strong, and the curative effect of the preparation is strong. The traditional Chinese medicine composition is used for treating ovarian cancers according to a qi-tonifying and toxin-clearing prescription principle, and can be combined with western medicines for treating ovarian cancer tumors, so that the curative effect of chemoradiotherapy is enhanced, the body immunity of a patient can be adjusted, and various side effects and adverse reactions caused by the chemoradiotherapy are reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition, preparation and preparation method for assisting the treatment of ovarian cancer. Background technique [0002] Ovarian cancer is one of the common malignant tumors in gynecology. Early lesions generally have no obvious symptoms and are usually diagnosed in the late stage. The mortality rate is high and the prognosis is poor. Its incidence rate ranks third among gynecological malignant tumors. Studies have shown that the crude incidence of ovarian cancer in my country may be relatively stable by 2020, and there is no downward trend. The current treatment methods for ovarian cancer include chemotherapy, surgery, and radiotherapy. Chemotherapy can effectively inhibit the growth of ovarian malignant tumors, but chemotherapy drugs have serious side effects, and long-term use is prone to drug resistance. The survival rate of tu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/896A61P35/00
CPCA61K36/54A61K36/704A61K36/88A61K36/896A61K36/90A61K2236/331A61K2236/39A61K2236/51A61K2236/55A61P35/00A61K2300/00
Inventor 荣汝成
Owner JIANGSU ZHENGYANG PHARM CO LTD
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