Cyclocarya paliurus extract and application thereof in preparation of anti-coronavirus drugs

A technology of coronavirus and extract, applied in the field of Cyclocarya paliurus extract and its preparation of anti-coronavirus drugs, achieving good safety, simple preparation method, and the effect of inhibiting cell pathological changes
CN112675211AActive Publication Date: 2021-04-20WEST CHINA HOSPITAL SICHUAN UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
WEST CHINA HOSPITAL SICHUAN UNIV
Publication Date
2021-04-20

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Abstract

The invention discloses a cyclocarya paliurus extract and application thereof in preparation of anti-coronavirus drugs. In the cyclocarya paliurus extract, the content of flavone is 20wt.%-40wt.%, the content of polysaccharide is 5wt.%-20wt.%, and the content ratio of the flavone to the polysaccharide is greater than or equal to 1.5: 1. Experimental results show that the cyclocarya paliurus extract with the specific flavone and polysaccharide content has SARS-CoV-2 virus neutralizing activity, can effectively inhibit cytopathy caused by the SARS-CoV-2 virus, and protects cells from being infected by the SARS-CoV-2 virus. The cyclocarya paliurus extract provided by the invention has a wide application prospect in preparation of anti-coronavirus (especially SARS-CoV-2 virus) medicines with good safety and low preparation cost.
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Description

technical field

[0001] The invention relates to the field of biomedicine, in particular to an extract of Cyclocarya paliurus and its use in preparing anti-coronavirus drugs. Background technique

[0002] There are currently 7 types of coronaviruses that can infect humans: HcoV-229E, HcoV-NL63, HcoV-HKU1, HcoV-OC43, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus ( MERS-CoV), 2019 novel coronavirus (2019-nCoV, SARS-CoV-2). Among them, SARS-CoV-2 is a new type of β-coronavirus, which belongs to single-stranded RNA virus, which is highly infectious and generally susceptible to the crowd. Although there is a certain understanding of the epidemiology, clinical characteristics, diagnosis, treatment, and prognosis of the new coronavirus pneumonia caused by SARS-CoV-2, the treatment still cannot meet the clinical needs, and there is a lack of specific drugs. Still pretty grim.

[0003] Most of the existing antiviral drugs are...

Claims

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