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Long-term preserved hemostatic composition, preparation method thereof and preparation method of long-term preserved antibacterial hemostatic mixture
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A technology for long-term storage and composition, which is applied in surgical adhesives, medical science, surgery, etc., and can solve problems such as uncontrollable effective substance content, high impurity content, and poor hemostatic effect
Inactive Publication Date: 2021-04-20
HUNAN UNIV OF TECH
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[0006] The purpose of the present invention is to make up for the deficiencies in the above-mentioned prior art, to provide a long-term preservation of the hemostatic composition, through the extraction of kapok root polysaccharides, effectively avoiding the existing kapok products with high impurity content and active substance content Unable to control, poor hemostatic effect and other problems
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[0032] The preparation method of the hemostatic composition preserved for a long time is obtained by introducing ionomycin calcium through kapok polysaccharide; the weight percentage of the added formula is as follows:
[0039] The long-term preservation hemostatic composition of the present embodiment, its calcification agent is calcium chloride, and the added formula component and its weight percentage are:
[0044] Unless otherwise specified, the ingredients are added according to the formula, kapok polysaccharide is added with ionomycin and calcifier, and the above-mentioned alcohol is used as the medium, stirred in a magnetic heating stirrer, the speed is 200r / min, and the temperature is maintained at 30°C. After reacting for 2 hours, the kapok polysaccharide compound ionomycin calcium precipitate was obtained, and the washing of the kapok polysaccharide compound ionomycin calcium was washing with 75% alcohol solution respectively, centrifuging twice, each time at 8000-10000r / min, centrifuging for 20 minutes, and then It can be obtained by drying at 80°C, filtering and crush...
Embodiment 2
[0048] The long-term preservation of the hemostatic composition of the present embodiment, its calcifying agent is calcium gluconate, the added formula components and their weight percentages are:
[0053] Unless otherwise specified, all materials are added according to the formula amount. Ionomycin and calcifier are added to the kapok polysaccharide, and the alcohol of the above content is used as the medium, stirred in a magnetic heating stirrer, the speed is 200r / min, and the temperature is maintained at 35°C. After reacting for 2 hours, the kapok polysaccharide compound ionomycin calcium precipitate was obtained, and the washing of the kapok polysaccharide compound ionomycin calcium was washing with 75% alcohol solution respectively, centrifuging twice, each time at 8000-10000r / min, centrifuging for 20 minutes, and then It can be obtained by drying at 80°C, ...
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Abstract
The invention provides a long-term preserved hemostatic composition. The hemostatic composition is obtained by introducing ionomycin calcium into kapok polysaccharide. The added formula comprises the following components in percentage by weight: 5%-10% of kapok polysaccharide, 75%-87% of ethanol, 5%-10% of ionomycin and 3%-5% of a calcifying agent. By extracting kapok root polysaccharide, the problems that an existing kapok product is high in impurity content, the content of effective substances cannot be controlled, the hemostatic effect is poor and the like are effectively solved. The ionomycin calcium is introduced into the kapok polysaccharide, and the hemostatic effect of kapok is combined with effective movable calciumion carriers. Because calcium ions (Ca<2+>) can react with blood coagulation factorsin vivo, a blood coagulation system is activated, an active hemostatic mechanism is realized, and the hemostatic effect is improved; and the hemostatic effect of the whole hemostatic composition can be optimal. Meanwhile, the invention provides a preparation method of the long-term preserved hemostatic composition. The preparation method of the long-term preserved hemostatic composition is simple to operate, high in operability and suitable for large-scale production and popularization.
Description
technical field [0001] The invention relates to the field of biotechnology, in particular to a long-term storage hemostatic composition and a preparation method thereof, and a preparation method of a long-term storage antibacterial hemostatic mixture. Background technique [0002] Studies have shown that when the blood volume loss of the wounded bleeding reaches 20%, about 800mL, the symptoms of shock may occur, and even life-threatening. How to quickly solve the problem of hemorrhage has attracted more and more people's attention. Especially in the case of large wound surface injury or arterial injury caused by an accident, the blood pressure is high, blood spurts out, a large amount of bleeding occurs in a short period of time, and the success rate of rescue is low. How to avoid shock or death caused by bleeding has become a difficult problem for scientists. Complete hemostasis within the golden minute after bleeding, reduce the incidence of hemorrhagic shock, buy time t...
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