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A kind of water-insoluble temperature pH double sensitive microgel and preparation method thereof

A water-insoluble, micro-gel technology, applied in the field of daily chemical industry, can solve problems such as limitations, and achieve a wide range and efficient control effect

Active Publication Date: 2022-04-15
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the prepared microgels are water-soluble. At present, there is no report on the preparation of oil-soluble multi-responsive microgels. The drug encapsulation conditions are limited, and the release rate is high. Large room for improvement

Method used

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  • A kind of water-insoluble temperature pH double sensitive microgel and preparation method thereof
  • A kind of water-insoluble temperature pH double sensitive microgel and preparation method thereof
  • A kind of water-insoluble temperature pH double sensitive microgel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) The temperature-sensitive hydrogel monomer N-isopropylacrylamide with a mass fraction of 10%, the mass fraction of 5% pH-sensitive hydrogel monomer dimethylaminoethyl methacrylate, the mass fraction 2% of the cross-linking agent N,N-methylenebisacrylic acid amine was placed in deionized water and vortexed until it was completely dissolved; in order to simulate the entrapment release experiment, a certain amount of dyeing agent was also added in this example, Specifically, add methylene blue dye with a mass fraction of 5%, and then vortex until completely dissolved;

[0042] (2) placing ethyl cellulose with a mass fraction of 0.5% in the oil phase of 2-n-octyl-1-dodecanol, heating and stirring until completely dissolved;

[0043] (3) The initiator azobisisobutylamidine hydrochloride with a mass fraction of 0.5% is placed in deionized water, and vortexed until completely dissolved;

[0044] (4) Nitrogen is passed into the oil phase solvent gained in step (2), to get ...

Embodiment 2

[0050] (1) The temperature-sensitive hydrogel monomer N-isopropylacrylamide with a mass fraction of 10%, the mass fraction of 5% pH-sensitive hydrogel monomer dimethylaminoethyl methacrylate, the mass fraction 2% of the cross-linking agent N,N-methylenebisacrylic acid amine was placed in deionized water and vortexed until it was completely dissolved; in order to simulate the entrapment release experiment, a certain amount of dyeing agent was also added in this example, Specifically, add methylene blue dye with a mass fraction of 5%, and then vortex until completely dissolved;

[0051] (2) placing ethyl cellulose with a mass fraction of 5% in the oil phase of 2-n-octyl-1-dodecanol, heating and stirring until completely dissolved;

[0052] (3) The initiator azobisisobutylamidine hydrochloride with a mass fraction of 0.5% is placed in deionized water, and vortexed until completely dissolved;

[0053] (4) Nitrogen is passed into the oil phase solvent gained in step (2), to get ri...

Embodiment 3

[0063] (1) The temperature-sensitive hydrogel monomer N-isopropylacrylamide with a mass fraction of 10%, the mass fraction of 5% pH-sensitive hydrogel monomer dimethylaminoethyl methacrylate, the mass fraction 2% of the cross-linking agent N,N-methylenebisacrylic acid amine was placed in deionized water and vortexed until it was completely dissolved; in order to simulate the entrapment release experiment, a certain amount of dyeing agent was also added in this example, Specifically, add methylene blue dye with a mass fraction of 5%, and then vortex until completely dissolved;

[0064] (2) placing ethyl cellulose with a mass fraction of 10% in the oil phase of 2-n-octyl-1-dodecanol, heating and stirring until completely dissolved;

[0065] (3) The initiator azobisisobutylamidine hydrochloride with a mass fraction of 0.5% is placed in deionized water, and vortexed until completely dissolved;

[0066] (4) Nitrogen is passed into the oil phase solvent gained in step (2), to get r...

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Abstract

The invention discloses a water-insoluble temperature-pH double-sensitive microgel and a preparation method thereof. The preparation method comprises: dissolving a temperature-sensitive hydrogel monomer, a pH-sensitive hydrogel monomer, and a cross-linking agent in water , to obtain an aqueous phase solution; add an initiator solution to the aqueous phase solution to obtain a mixed solution; place the polymer in the oil phase for dissolution, feed nitrogen into the solution to get rid of oxygen, and obtain an oil phase solution; The mixed solution is added to the oil phase solution, sheared and mixed to obtain an emulsion; the emulsion is cross-linked by ultraviolet light, washed and then freeze-dried. In the present invention, a layer of ethyl cellulose film is attached to the surface of the microgel, so that the prepared microgel is water-insoluble, and the slow-release effect of the microgel and its application in an oily environment are greatly improved.

Description

technical field [0001] The invention belongs to the technical field of daily chemical industry, and in particular relates to a water-insoluble temperature-pH double-sensitive microgel and a preparation method thereof. Background technique [0002] Hydrogel is a natural hydrophilic polymer, which is generally cross-linked by physical or chemical behavior to form a three-dimensional network structure, and has extremely strong swelling properties in water. It is mainly divided into two categories, one is environment-responsive gel, which can change hydrophilicity and hydrophobicity according to changes in external temperature, pH, electromagnetic, etc.; the other is environment-unresponsive hydrogel, which is sensitive to the outside world Changes have not changed significantly. Due to the special properties of environment-responsive gels, it has attracted extensive attention. The temperature / pH dual-stimulation corresponding microgels have become a research hotspot in recent ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/54C08F220/34C08F222/38C08J3/075C08J3/28C08J3/24
Inventor 孙亚娟齐佳悦吕妍杨成
Owner JIANGNAN UNIV
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