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Water-insoluble temperature and pH double-sensitive microgel and preparation method thereof

A water-insoluble, micro-gel technology, applied in the field of daily chemical industry, can solve problems such as limitations, and achieve a wide range and efficient control effect

Active Publication Date: 2021-04-20
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the prepared microgels are water-soluble. At present, there is no report on the preparation of oil-soluble multi-responsive microgels. The drug encapsulation conditions are limited, and the release rate is high. Large room for improvement

Method used

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  • Water-insoluble temperature and pH double-sensitive microgel and preparation method thereof
  • Water-insoluble temperature and pH double-sensitive microgel and preparation method thereof
  • Water-insoluble temperature and pH double-sensitive microgel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) The temperature-sensitive hydrogel monomer N-isopropylacrylamide with a mass fraction of 10%, the mass fraction of 5% pH-sensitive hydrogel monomer dimethylaminoethyl methacrylate, the mass fraction 2% of the cross-linking agent N,N-methylenebisacrylic acid amine was placed in deionized water and vortexed until it was completely dissolved; in order to simulate the entrapment release experiment, a certain amount of dyeing agent was also added in this example, Specifically, add methylene blue dye with a mass fraction of 5%, and then vortex until completely dissolved;

[0042] (2) placing ethyl cellulose with a mass fraction of 0.5% in the oil phase of 2-n-octyl-1-dodecanol, heating and stirring until completely dissolved;

[0043] (3) The initiator azobisisobutylamidine hydrochloride with a mass fraction of 0.5% is placed in deionized water, and vortexed until completely dissolved;

[0044] (4) Nitrogen is passed into the oil phase solvent gained in step (2), to get ...

Embodiment 2

[0050] (1) The temperature-sensitive hydrogel monomer N-isopropylacrylamide with a mass fraction of 10%, the mass fraction of 5% pH-sensitive hydrogel monomer dimethylaminoethyl methacrylate, the mass fraction 2% of the cross-linking agent N,N-methylenebisacrylic acid amine was placed in deionized water and vortexed until it was completely dissolved; in order to simulate the entrapment release experiment, a certain amount of dyeing agent was also added in this example, Specifically, add methylene blue dye with a mass fraction of 5%, and then vortex until completely dissolved;

[0051] (2) placing ethyl cellulose with a mass fraction of 5% in the oil phase of 2-n-octyl-1-dodecanol, heating and stirring until completely dissolved;

[0052] (3) The initiator azobisisobutylamidine hydrochloride with a mass fraction of 0.5% is placed in deionized water, and vortexed until completely dissolved;

[0053] (4) Nitrogen is passed into the oil phase solvent gained in step (2), to get ri...

Embodiment 3

[0063] (1) The temperature-sensitive hydrogel monomer N-isopropylacrylamide with a mass fraction of 10%, the mass fraction of 5% pH-sensitive hydrogel monomer dimethylaminoethyl methacrylate, the mass fraction 2% of the cross-linking agent N,N-methylenebisacrylic acid amine was placed in deionized water and vortexed until it was completely dissolved; in order to simulate the entrapment release experiment, a certain amount of dyeing agent was also added in this example, Specifically, add methylene blue dye with a mass fraction of 5%, and then vortex until completely dissolved;

[0064] (2) placing ethyl cellulose with a mass fraction of 10% in the oil phase of 2-n-octyl-1-dodecanol, heating and stirring until completely dissolved;

[0065] (3) The initiator azobisisobutylamidine hydrochloride with a mass fraction of 0.5% is placed in deionized water, and vortexed until completely dissolved;

[0066] (4) Nitrogen is passed into the oil phase solvent gained in step (2), to get r...

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Abstract

The invention discloses water-insoluble temperature and pH double-sensitive microgel and a preparation method thereof. The preparation method comprises the steps: placing a temperature-sensitive hydrogel monomer, a pH-sensitive hydrogel monomer and a cross-linking agent in water to be dissolved, to obtain an aqueous phase solution; adding an initiator solution into the aqueous phase solution to obtain a mixed solution; placing a high-molecular polymer in an oil phase, dissolving and introducing nitrogen into the solution to remove oxygen, so as to obtain an oil phase solution; adding the mixed solution into the oil phase solution, and shearing and mixing to obtain an emulsion; and carrying out ultraviolet irradiation crosslinking on the emulsion, washing, and carrying out freeze drying. A layer of ethyl cellulose film is attached to the surface layer of the microgel, so that the prepared microgel has water insolubility, the slow release effect of the microgel is greatly improved, and the application of the microgel in an oily environment is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of daily chemical industry, and in particular relates to a water-insoluble temperature-pH double-sensitive microgel and a preparation method thereof. Background technique [0002] Hydrogel is a natural hydrophilic polymer, which is generally cross-linked by physical or chemical behavior to form a three-dimensional network structure, and has extremely strong swelling properties in water. It is mainly divided into two categories, one is environment-responsive gel, which can change hydrophilicity and hydrophobicity according to changes in external temperature, pH, electromagnetic, etc.; the other is environment-unresponsive hydrogel, which is sensitive to the outside world Changes have not changed significantly. Due to the special properties of environment-responsive gels, it has attracted extensive attention. The temperature / pH dual-stimulation corresponding microgels have become a research hotspot in recent ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/54C08F220/34C08F222/38C08J3/075C08J3/28C08J3/24
Inventor 孙亚娟齐佳悦吕妍杨成
Owner JIANGNAN UNIV
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