Method for determining content of clindamycin phosphate vaginal tablets

A clindamycin phosphate and assay method technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of unclear separation of the main peak, large decrease in the content of the main peak, long retention time of the main peak, etc.
CN112684056AActive Publication Date: 2021-04-20HAINAN HAISHEN TONGZHOU PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HAINAN HAISHEN TONGZHOU PHARM CO LTD
Publication Date
2021-04-20

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Abstract

The invention provides a method for determining the content of clindamycin phosphate vaginal tablets. The method adopts high performance liquid chromatography for detection, selects mobile phase components, adopts scientific proportioning, adopts gradient elution and sets elution conditions, and can rapidly and accurately detect the content of clindamycin hydrochloride for injection so as to achieve the purpose of simply, conveniently, rapidly and accurately controlling the product quality.
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Description

technical field

[0001] The invention relates to the field of drug analysis, in particular to a method for determining the content of clindamycin phosphate vaginal tablets. Background technique

[0002] Clindamycin phosphate is a semi-synthetic antibacterial drug widely used in serious infections caused by Gram-positive cocci and anaerobic bacteria. It is a semi-synthetic antibiotic and a derivative of lincomycin. Clindamycin phosphate is ineffective in vitro and can be rapidly converted into antibacterially effective clindamycin in vivo. The clindamycin phosphate vaginal tablet has a high cure rate and a short course of treatment for bacterial vaginosis, and has the characteristics of convenient production and use and quick onset of effect.

[0003] Patent CN103487518B, using octadecylsilane bonded silica gel as filler; potassium dihydrogen phosphate solution-methanol as mobile phase, using high performance liquid chromatography for detection, the key control detection cond...

Claims

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