Vigabatrin solid preparation and preparation method thereof
A technology of vigabatrin and solid preparations, applied in pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc.
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[0047] The present invention also provides a method for preparing vigabatrin tablets, the preparation method comprising: dissolving the adhesive in the first anhydrous alcohol solvent to obtain an adhesive solution; dissolving vigabatrin, filler, disintegrant etc. (also including alginic acid) are mixed with the binding solution, granulated, and dried to obtain dried granules; the dried granules and lubricant are mixed and compressed to obtain the described Vigabatrin tablets.
[0048] In some other embodiments of the present invention, the present invention provides a method for preparing a vigabatrin coated tablet, the preparation method comprising: dissolving the binder in the first anhydrous alcohol solvent, so as to obtain A binding solution; mixing vigabatrin, fillers, disintegrants, etc. (also including alginic acid) with the binding solution, granulating, and drying to obtain dried granules; The lubricant is mixed and pressed into tablets, so as to obtain vigabatrin t...
Embodiment 1
[0054] Embodiment 1 provides a vigabatrin film-coated tablet and a preparation method thereof, wherein the ingredients of the vigabatrin film-coated tablet are shown in Table 1 below:
[0055] Table 1 Composition of vigabatrin film-coated tablets
[0056]
[0057]
[0058] The preparation method of this vigabatrin film-coated tablet is as follows:
[0059] (1) According to Table 1, ethyl cellulose and povidone K30 were weighed and dissolved in wetting agent absolute ethanol to prepare a 10% by mass adhesive solution.
[0060] (2) According to Table 1, weigh the raw materials vigabatrin, microcrystalline cellulose, sodium carboxymethyl starch, and alginic acid and place them in a wet mixing granulator, mix for a few minutes until uniform, and then add the above-mentioned ethyl cellulose containing Adhesive solution of polyvinyl alcohol and povidone K30, cutting and stirring while adding to make soft material.
[0061] (3) Pass the prepared soft material through a 24-mes...
Embodiment 2
[0066] Embodiment 2 provides a vigabatrin film-coated tablet and a preparation method thereof, wherein the ingredients of the vigabatrin film-coated tablet are shown in Table 2 below:
[0067] Table 2 Composition of vigabatrin film-coated tablets
[0068]
[0069]
[0070] Preparation:
[0071] (1) According to Table 2, ethyl cellulose and povidone K30 were weighed and dissolved in anhydrous isopropanol as a wetting agent to prepare a binding solution with a mass percentage of 12%.
[0072] (2) According to Table 2, the raw materials vigabatrin, mannitol, sodium carboxymethyl starch, and alginic acid were weighed and placed in a wet mixing granulator, mixed for a few minutes until uniform, and then added the above-mentioned The bonding solution of povidone K30 is cut and stirred while adding to make soft materials.
[0073](3) Pass the prepared soft material through a 24-mesh sieve, granulate, and then put it into an oven at 45° C. for drying.
[0074] (4) Take out th...
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