43 results about "Hexacosenoic acid" patented technology

The invention provides application of a mo-based catalyst loaded by an unreduced or partially reduced polymetallic oxide in preparation of an organic chemical product with lignin. The application comprises the steps of after the lignin, the catalyst and a reaction solvent are mixed, adding a mixture into a sealed reaction container, introducing gas into the container, increasing the temperature at230-350 DEG C, stirring the mixture and making the mixture react for 0.5-12 h, after reaction, filtering out the catalyst, conducting rotary evaporation, and obtaining the liquid product. The application of the mo-based catalyst loaded by the unreduced or partially reduced polymetallic oxide in preparation of the organic chemical product with the lignin has the advantages that the catalyzing process has a high yield of product, on the optimized reaction condition, the total mass yield of a micromolecule organic product reaches 349%, which is because solvent molecules and lignin depolymerizedsmall molecules are combined further to generate useful molecules such as ethyl caproate, ethyl cis-3-hexenoate, 4-ethyl cis-3-hexenoate, ethyl 3-methylvalerate, 3-ethyl trans-2-octenoate and ethyl caprylate, the product contains aromatic compounds such as monophenol applied to industry in large amounts, the additional value of the catalyst is high, and the catalyst has a good industrial application prospect.

The invention belongs to the technical field of biological pharmacy, and particularly discloses a carbonyl reductase/isopropanol dehydrogenase co-immobilized catalyst as well as a preparation method and application thereof. According to the invention, carbonyl reductase and isopropanol dehydrogenase are co-embedded in a solid phase carrier obtained from polyvinyl alcohol and polyethylene glycol; the obtained co-immobilized enzyme catalyst can realize efficient and high stereoselectivity reduction of 3-carbonyl-5-hexenoic acid ester to generate (R)-3-hydroxy-5-hexenoic acid ester through catalysis of carbonyl reductase and circulation of isopropanol dehydrogenase on coenzyme NADPH. The catalyst can be used for preparing (R)-3-hydroxy-5-hexenoic acid ester by taking 3-carbonyl-5-hexenoic acid ester as a substrate, and the co-immobilized catalyst prepared by the method disclosed by the invention is high in catalytic efficiency, good in stability, reusable, concise in process and low in cost, and has excellent actual industrial application value.

The invention belongs to the technical field of daily use chemicals, and discloses a method for synthesizing racemic sclareolide. The synthetic method comprises the step of: making 4-methly-6-(2,6,6-trimethyl-1-cyclohexenyl)-3-hexene-1-acid serving as a raw material react with a solid super acid serving as a catalyst in an organic solvent to obtain racemic sclareolide. The method for synthesizing the racemic sclareolide is environmentally-friendly, is easy to operate, and has high yield; and the catalyst used in the synthetic method can be used repeatedly, so that the production cost is lowered, and the method is more suitable for industrial production.

The invention discloses an amhexenoic acid preparation liquid composition and also discloses an oral solution prepared from the composition and a diluent, and the solution is suitable for treating CNS diseases, such as patients with resistant epilepsy, complex partial epileptic seizure, secondary systemic epileptic seizure, refractory complex partial seizure and infant spasm. The dosage form capable of being used for multiple times is good in stability, convenience is provided for medical staff, patient compliance is improved, human errors during dosage are reduced, and the medication safety of children and babies is also improved.

The invention discloses a preparation method of (2S, 3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride, and belongs to the technical field of preparation of a medical intermediate. The chiral product of the (2S, 3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride is obtained by performing the five reaction steps, including epoxidation, resolution, ring opening, esterification and amination, on trans-2-hexenoic acid serving as an initial raw material, wherein water is used as a reaction solvent in the first step of epoxidation. By adoption of the technology, the preparation method has the advantages of convenience in operation, mild reaction conditions, cheap and readily available used raw materials, low toxicity, high product purity reaching over 99.4 percent, high e.e. (Enantionmeric Excess) value reaching over 99.5 percent, low equipment requirement and suitability for large-scale industrial production.

The invention discloses a method for preparing 3-amino-N-cyclopropyl-2-hydroxyhexanamide, and belongs to the technical field of the preparation of medicinal intermediates. The method comprises the step that 3-amino-N-cyclopropyl-2-hydroxyhexanamide is prepared from trans-2-hexenoic acid by epoxidation, esterification, reduction and other steps. The method has readily-available raw materials and stable process condition, and is suitable for scale industrial production. The 3-amino-N-cyclopropyl-2-hydroxyhexanamide is conveniently prepared from readily-available and low-toxicity raw materials by the step above under a mild reaction condition; the total yield is as high as above 61%, the product has high purity which is as high as above 99.4%; and furthermore, the method achieves high yield and a high-purity product, has a low requirement on the equipment and is suitable for industrial production.

The invention discloses a preparation method of aminohexenoic acid, which is characterized by comprising the following steps: with diethyl malonate and 1,4-dichloro-2-butene as raw materials, preparing 2-vinylcyclopropane-1,1-dicarboxylic acid diethyl ester; then carrying out a reaction on 2-vinylcyclopropane-1,1-dicarboxylic acid diethyl ester in the presence of ammonia and formamide to prepare 2-carbonyl-5-vinyl-pyrrolidine-3-amide; preparing a 4-amino-5-hexenoic acid crude product from the 2-carbonyl-5-vinyl-pyrrolidine-3-amide under an acidic condition; then preparing triisopropylsilyl-4-aminohexyl-5-alkenyl ester from 4-amino-5-hexenoic acid and triisopropylchlorosilane in the presence of triethylamine and ammonia; recrystallizing the triisopropylsilyl-4-aminohexyl-5-alkenyl ester inchloroform/methanol to obtain a purified product of the triisopropylsilyl-4-aminohexyl-5-alkenyl ester; wherein the volume ratio of chloroform to methanol is 1:7; and hydrolyzing the purified productof the triisopropylsilyl-4-aminohexyl-5-alkenyl ester under an alkaline condition to obtain the aminohexylenic acid.

The invention discloses a synthesis method for trans-3-hexenoic acid. According to the synthesis method, butyl aldehyde and malonic acid are used as starting raw materials, and triethanolamine is used as a catalyst. The synthesis method comprises the following steps of: preparing mixed solution, i.e., uniformly mixing and stirring the triethanolamine and the malonic acid according to the proportion of 1:3-3:1; performing dropping reaction, i.e., stirring and dropwise adding the mixed solution into the butyl aldehyde, charging N2 to protect the butyl aldehyde, heating to 60-100 DEG C, and separating by using an oil-water separator to remove water produced by the reaction, wherein the reaction time is 2-4 hours; and fractionating, i.e., removing the butyl aldehyde and front cut fraction through fractionation and then evaporating out a finished product. The trans-3-hexenoic acid synthesized by using the method has the characteristics of less isomer, mild reaction, simple process, high yield and no solvent residue.

The invention provides an aminohexenoic acid intermediate 2-vinyl cyclopropane-1, 1-diethyl dicarboxylate and a preparation method thereof, application of the aminohexenoic acid intermediate 2-vinyl cyclopropane-1, 1-diethyl dicarboxylate in preparation of aminohexenoic acid, an aminohexenoic acid product and a preparation method thereof. The preparation method of the 2-vinyl cyclopropane-1, 1-diethyl dicarboxylate comprises the steps: (1) reacting 1, 4-dichloro-2-butene with diethyl malonate in a sodium ethoxide solution to obtain a reaction solution containing 2-vinyl cyclopropane-1, 1-diethyl dicarboxylate; and (2) carrying out purification treatment on the reaction solution, wherein the purification treatment comprises the steps: directly cooling and filtering the reaction solution, and collecting a filtrate containing 2-vinyl cyclopropane-1, 1-diethyl dicarboxylate. The 2-vinyl cyclopropane-1, 1-diethyl dicarboxylate prepared by the preparation method is high in yield, high in purity, few in solvent residue and raw material residue, simple, convenient and rapid to operate, free of wastewater discharge and suitable for large-scale production.

The invention discloses a preparation method of 5-methyl-5-ethyl hexenoate. The method comprises the following steps: 1) adding ethyl acrylate, benzene and a catalyst into a four-neck flask, controlling the temperature to be 25-30 DEG C, introducing isobutene, preserving heat for 24-60 hours, adding a sodium bicarbonate aqueous solution, stirring for 0.5-1 hour, adding a mixed solution of hydrochloric acid and water, stirring for 0.5 hour, standing for 0.5 hour, layering, and washing with water to obtain a water layer and a benzene layer; and 2) adding the benzene layer into a barrel, adding adehydrating agent, dehydrating, concentrating, carrying out normal pressure distillation and reduced pressure distillation in sequence, and collecting the azeotropic fraction to obtain the 5-methyl-5-ethyl hexenoate. According to the preparation method of the 5-methyl-5-ethyl hexenoate, aluminum trichloride and tungsten hexachloride are synergistically used as catalysts, the total yield can reach46.7% or above, anhydrous sodium sulfate and n-butyl alcohol are used as dehydrating agents, and the product purity can reach 97.5% or above; and the preparation method disclosed by the invention issimple to operate and relatively low in cost.

The present invention provides a process for preparing 2-isopropenyl-5-methyl-4-hexenoic acid of the following formula (4), comprising steps of:

• • subjecting a Grignard reagent of the following general formula (1), wherein R¹ represents a linear, branched, or aromatic monovalent hydrocarbon group having 1 to 8 carbon atoms, and X represents a chlorine atom, a bromine atom, or an iodine atom, and 1,1,1,3,3,3-hexamethyldisilazane to a deprotonation reaction to form a 1,1,1,3,3,3-hexamethyldisilazane derivative; and subjecting 2-methyl-3-buten-2-yl 3-methyl-2-butenoate of the following formula (3) to a rearrangement reaction in the presence of the 1, 1, 1,3,3,3-hexamethyldisilazane derivative to form 2-isopropenyl-5-methyl-4-hexenoic acid (4).

The invention discloses a synthesis method of (+/-)-lavandulol. The synthesis method comprises the following steps: (1) carrying out substitution reaction on ethyl acetoacetate and 1-bromo-3-methyl-2-butene under an alkaline condition to prepare 2-acetyl-5-methylhex-4-olefine acid ethyl ester; (2) carrying out a Wittig reaction on the ethyl 2-acetyl-5-methylhexyl-4-olefine acid ester and a methyl Wittig reagent in an organic solvent, so as to prepare ethyl lavandulamate; and (3) reducing the ester group of the ethyl lavandulate into alcohol under the action of lithium aluminum hydride to prepare the final product (+/-)-lavandulol. The method has the advantages of low raw material price, short process route, few post-treatment steps and high reaction yield, and is a production process with a relatively good production prospect.

The invention discloses the application of Z, 3-hexenyl Z, 3-hexenoate as the liriomyza sativae attractant for the first time. The Z, 3-hexenyl Z, 3-hexenoate has an attractive effect on liriomyza sativae in the field, and the attractive effect is remarkable. Therefore, liriomyza sativae can be accurately lured and killed, the number of field populations is reduced, and the method is used for liriomyza sativae prevention and control, insect situation monitoring and the like. The insecticidal composition does not harm beneficial insects, human and livestock, crops and natural enemies, target pests do not generate resistance, and the insecticidal composition has the advantages of being natural, environmentally friendly and the like.

The present invention discloses a method for preparing 3-amino-N-cyclopropyl-2-hydroxyl-hexanamide. The invention relates to the technical field of the preparation of pharmaceutical intermediates. The method uses trans-2-hexenoic acid as the starting material, through the steps of epoxidation, ring-opening by nitrile, amidation, etc., to obtain the final product 3-amino-N-cyclopropyl-2-hydroxyl-hexanamide. The method uses easily-obtainable materials, requires mild reactive conditions, and adopts stable processes. Therefore it is suitable for large scale industrial production.