Combined application of arabinose and silicone oil-based defoamer to intestinal preparation

An arabinose and intestinal preparation technology, applied in the field of arabinose and silicone oil defoamer and intestinal preparation, can solve the problems of affecting the clarity of intestinal mucosa, reducing the detection rate of polyps, and lack of drugs to reduce intestinal cleaning agents.

Active Publication Date: 2021-06-01
ZHONGSHAN HOSPITAL FUDAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] When the existing bowel cleansing agent is used in the intestinal preparation process, the air bubbles attached to the intestinal mucosa in the intestinal tract adversely affect the colonoscopy observation. Clinical observations have found that when PEG is used as a intestinal preparation drug, air bubbles often appear and affect the clarity of the intestinal mucosa , reducing the polyp detection rate
However, among the existing bowel preparation drugs, there is a lack of drugs that can effectively reduce the generation of intestinal gas bubbles during bowel cleansing.

Method used

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  • Combined application of arabinose and silicone oil-based defoamer to intestinal preparation
  • Combined application of arabinose and silicone oil-based defoamer to intestinal preparation
  • Combined application of arabinose and silicone oil-based defoamer to intestinal preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0178] The present embodiment 1 prepares a kind of defoaming milk, and the prescription of defoaming milk and preparation method thereof are as follows:

[0179] The prescription of defoaming milk is shown in Table 1 below:

[0180] Table 1 The prescription composition of antifoaming milk

[0181]

[0182]

[0183] Preparation method of defoaming milk:

[0184] (1) Stir and mix the prescribed amount of water, L-arabinose and polysorbate-80, then heat to 70°C to obtain the aqueous phase A;

[0185] (2) Stir and mix the prescribed amount of simethicone and sorbitan monooleate and heat to 70°C to obtain oily phase B;

[0186] (3) Slowly inject the oily phase B into the watery phase A under stirring, continue to stir evenly for 6 minutes, homogenize at 12000 rpm for 5 minutes with a homogenizer, and fully emulsify to obtain an oil-in-water emulsion (that is, an oil-in-water emulsion) defoaming milk).

[0187] Particle size performance determination:

[0188] The average...

Embodiment 2

[0190] This example 2 investigates the defoaming effect of simethicone and L-arabinose on PEG in intestinal preparation process

[0191] 1. Compound polyethylene glycol electrolyte powder:

[0192] The compound polyethylene glycol electrolyte powder is prepared by mixing the following components: 1.46g of sodium chloride, 5.68g of anhydrous sodium sulfate, 0.74g of potassium chloride, 1.68g of sodium bicarbonate and 400060g of polyethylene glycol.

[0193] 2. Experimental method:

[0194] Healthy and clean beagle dogs, weighing 20-21kg, were randomly divided into experimental group 1, experimental group 2, experimental group 3, experimental group 4 and experimental group 5, with 20 dogs in each group, half male and half male.

[0195] The beagle dogs in each group were fasted at 12:00 noon on the same day, and the beagle dogs in each group were administered orally as follows at 8:00 pm;

[0196] Experimental group 1: Gastrointestinal compound polyethylene glycol electrolyte ...

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Abstract

The invention relates to combined application of arabinose and a silicone oil type defoaming agent to intestinal preparation. Specifically, the invention provides application of the composition, the composition is used for preparing a medicine, and the medicine is used for (i) reducing the generation of intestinal bubbles in a bowel cleaning process of a bowel cleaning agent; and/or (ii) in combination with a gut purging agent for gut preparation; wherein the composition comprises arabinose and a silicone oil defoaming agent. The combination of the arabinose and the silicone oil defoaming agent can effectively reduce intestinal bubbles in the process of cleaning the intestines by the gut cleaning agent, so that the clarity of intestinal mucosa and the quality of intestinal preparation are improved.

Description

technical field [0001] The invention relates to the field of medicines, in particular to an arabinose and silicone oil defoamer used in combination for bowel preparation. Background technique [0002] With the development of endoscopic technology, colonoscopy has been widely used clinically and has become one of the main means of diagnosis and treatment of various intestinal diseases. Colonoscopy is affected by bowel preparation to some extent. It is extremely important to make adequate bowel preparation before surgery to improve the image quality of colonoscopy to improve the detection rate of colonic diseases. [0003] The visibility of the intestinal mucosa is an index to evaluate the cleanliness of the intestinal tract, and an important factor affecting the visibility of the intestinal mucosa is intestinal air bubbles. In the human body, gas in intestinal air bubbles is mainly caused by the following factors: ① gas swallowed consciously or unconsciously; ② bacteria in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
CPCA61K49/0004Y02A50/30
Inventor 周平红蔡明琰石国良王羽娟林卫军
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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