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Photoinduced dielectrophoresis particle separation method based on continuous flow

A technology of light-induced dielectrophoresis and separation method, which is applied in the field of microfluidics to achieve the effects of reasonable design, weakening hydrolysis phenomenon and simple structure

Pending Publication Date: 2021-06-01
HAINAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The technical problem to be solved by the present invention is how to overcome the limitation that the existing two kinds of particle separation devices need to preset complicated physical electrodes, so as to provide a light-induced dielectrophoretic particle separation method based on continuous flow, which has at least simple structure, Advantages of low cost, flexible operation and strong scalability

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  • Photoinduced dielectrophoresis particle separation method based on continuous flow
  • Photoinduced dielectrophoresis particle separation method based on continuous flow
  • Photoinduced dielectrophoresis particle separation method based on continuous flow

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Embodiment Construction

[0030] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments. It should be appreciated, however, that the embodiments provide many applicable concepts that can be implemented in a wide variety of specific contexts. The discussed and disclosed embodiments are for illustration only, and are not intended to limit the scope of the present invention.

[0031] Furthermore, terms that are relative in space, such as center, vertical, horizontal, up, down, front, back, left, right, top, bottom, inside, outside, vertical, horizontal, surface, etc., are for ease of explanation The relationship between one element or feature and another element or feature in a drawing. These spatially relative terms cover different orientations in use and operation of the device in addition to the orientation depicted in the figures. These devices may also be rotated (eg, 90 degrees or to other orientations), and spatially relative d...

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Abstract

The invention belongs to the field of micro-fluidic chips, and discloses a photoinduced dielectrophoresis particle separation method based on continuous flow. The method is characterized in that illumination is applied to different positions of a photoinduced dielectrophoresis chip, conductivity of corresponding positions is changed, a non-uniform electric field is generated, two particles in a microfluid channel are driven to move, and due to the fact that the radiuses and dielectric constants of the two particles are different, photoinduced dielectrophoresis forces borne by the particles are different, and thus different particles are separated out. The method has the advantages that the separation efficiency is high; particle samples needing to be collected are few; two kinds of particles do not need to be marked respectively so that the damage to a separated object is small; a complex microfluid channel does not need to be designed, a complex electrode does not need to be designed, and the two kinds of particles can be separated only by applying light to different positions according to needs.

Description

technical field [0001] The invention relates to the field of microfluidics, in particular to the field of microfluid separation, and mainly relates to a continuous flow-based light-induced dielectrophoretic particle separation method. Background technique [0002] Microfluidic chips have become a hot field of research due to their miniaturization, portability, high degree of integration, and low cost. New technologies in many fields; microfluidic chips can be applied to the manipulation, separation and screening of biological cells and micro-nano particles, especially in the research fields of tumor cell research, somatic cell research, and genome mapping; It is of great significance to isolate target cells from their surrounding environment during the diagnosis and treatment of cancer. [0003] In microfluidic technology, the separation of micro-nano particles and cells can be divided into two categories: one is to use special microchannel structure and microfluidic dynami...

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Application Information

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IPC IPC(8): B01D57/02
CPCB01D57/02
Inventor 史留勇钟翔涛丁行行邓鲁豫黄志维何孝涵周腾
Owner HAINAN UNIVERSITY
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