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Chitosan sodium hyaluronate antibacterial liquid film and preparation method thereof

A technology of sodium hyaluronate and chitosan, applied in medical science, bandages, etc., can solve the problems of inability to take into account the waterproof and breathable wounds, moisturizing the skin and resisting ultraviolet rays, poor biocompatibility and degradability, and poor waterproof and breathable permeability. Easy to observe the wound condition, good skin comfort, and the effect of preventing wound infection

Pending Publication Date: 2021-06-04
周建大
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional dressings mainly include natural gauze, synthetic fiber inner dressings, foaming polymer dressings, hydrocolloid dressings, etc., which have poor biocompatibility and degradability, and these dressings are easy to provide a breeding ground for the invasion of bacteria and other microorganisms , so the requirements for sterilization are extremely high; in addition, the traditional dressing is not tightly adhered, and the tape will cause the skin to turn white, and the waterproof and breathable properties are poor
Although there are products similar to liquid band-aids on the market, these products cannot take into account the waterproof and breathable properties of the wound, moisturizing the skin, and resisting ultraviolet rays.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A chitosan sodium hyaluronate antibacterial liquid film, comprising the following components in parts by weight: 4-6 parts of chitosan, 1-2 parts of cell growth factor FGF, 10-12 parts of sodium hyaluronate, 2-2 parts of glycerophospholipids 4 parts, 6-8 parts of coconut oil, 2-4 parts of propylene glycol, 48-52 parts of butyl acetate, 12-15 parts of ethyl acetate.

[0019] The preparation method of above-mentioned chitosan sodium hyaluronate antibacterial liquid film is as follows:

[0020] S1: Put butyl acetate, ethyl acetate and propylene glycol in a container and mix evenly to obtain a mixed solution;

[0021] S2: Add cell growth factors, sodium hyaluronate, glycerophospholipids, and coconut oil weighed according to the ratio to the mixed solution, and ultrasonically dissolve them to completely dissolve each component to form solution A;

[0022] S4: Use lactic acid to dissolve chitosan, adjust the pH to 5.5-6.5, add to the solution A in step S3, heat to 35-40°C, s...

Embodiment 2

[0028] A chitosan sodium hyaluronate antibacterial liquid film, comprising the following components in parts by weight: 4-6 parts of chitosan, 1-2 parts of cell growth factor, 10-12 parts of sodium hyaluronate, 2-4 parts of glycerophospholipids 6-8 parts of coconut oil, 2-4 parts of propylene glycol, 48-52 parts of butyl acetate, 12-15 parts of ethyl acetate, 3-5 parts of antibacterial nanoparticles, 10-12 parts of active protective agent, polyethylene glycol 1-2 parts of alcohol. The antibacterial nanoparticles in this embodiment are nano silver, and the active protective agent in this embodiment is trehalose.

[0029] The preparation method of above-mentioned chitosan sodium hyaluronate antibacterial liquid film comprises the following steps:

[0030] S1: Put butyl acetate, ethyl acetate and propylene glycol in a container and mix evenly to obtain a mixed solution;

[0031] S2: Add polyethylene glycol weighed according to the proportion to the mixed solution in step S1, st...

Embodiment 3

[0040] A chitosan sodium hyaluronate antibacterial liquid film, comprising the following components in parts by weight: 48 parts of butyl acetate, 12 parts of ethyl acetate, 6 parts of chitosan, 8 parts of coconut oil, 3 parts of propylene glycol, polyethylene glycol 2 parts of alcohol (molecular weight is 4000), 2 parts of cell growth factor, 5 parts of antibacterial nanoparticles, 12 parts of active protective agent, 4 parts of glycerophospholipid. The cell growth factor in this embodiment is FGF, the antibacterial nanoparticles are nano silver, and the active protective agent is trehalose.

[0041] The preparation method of above-mentioned liquid film comprises the following steps:

[0042] S1: Put butyl acetate, ethyl acetate and propylene glycol in a container and mix evenly to obtain a mixed solution;

[0043] S2: Add polyethylene glycol weighed according to the proportion to the mixed solution in step S1, stir evenly, and wait until the components are stable;

[0044]...

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PUM

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Abstract

The invention relates to the technical field of medical liquid dressings, and discloses a chitosan sodium hyaluronate antibacterial liquid film which comprises chitosan, cell growth factors, sodium hyaluronate, glyceryl phospholipid, coconut oil, propylene glycol, butyl acetate and ethyl acetate. The chitosan sodium hyaluronate antibacterial liquid film can form a film quickly, is tightly attached to the skin after film formation, not only can sterilize and inhibit bacteria, promote wound healing and prevent wound infection, but also has the advantages of isolating invasion of ultraviolet rays, harmful substances and pollutants and deeply moistening the skin; The chitosan sodium hyaluronate antibacterial liquid film is waterproof, breathable, good in skin affinity and good in skin comfort, and the protective film has the characteristics of being good in ductility, free of influence on flexibility of joint parts, convenient to use, easy to observe wound conditions, capable of promoting wound recovery and the like, and can naturally fall off in the later period without worries.

Description

technical field [0001] The invention relates to the technical field of medical liquid dressings, in particular to a chitosan sodium hyaluronate antibacterial liquid film and a preparation method thereof. Background technique [0002] Skin damage happens from time to time in life. Wound repair is a complex process. The use of dressings plays a very important role in promoting wound healing. It can protect the wound from external aggression, and the body also uses its own healing and repairing ability to wait wound healing. Wound healing is also a process of tissue repair, and the interaction between extracellular matrix (ECM) and cells during tissue repair can significantly affect the occurrence or reconstruction of tissue morphology. [0003] Dressing is a medical material widely used clinically to cover sores, wounds or other damages. Traditional dressings mainly include natural gauze, synthetic fiber inner dressings, foaming polymer dressings, hydrocolloid dressings, etc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0019A61L26/0023A61L26/0047A61L26/0057A61L26/0061A61L26/0066A61L2300/104A61L2300/232A61L2300/236A61L2300/30A61L2300/402A61L2300/404A61L2300/408A61L2300/412A61L2300/414A61L2300/418C08L5/08C08L89/00C08L71/02
Inventor 周建大耿金秀曾寒凌陈政陈佳唐封杰
Owner 周建大
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