Test strip for double-line detection of antibody after novel coronavirus vaccine inoculation

A virus vaccine and line detection technology, which is applied in the field of test strips for double-line detection of antibodies after vaccination against the new coronavirus, can solve the problems of invalid test strip test results and inability to explain the formation of protection at the same time, so as to prevent poor vaccination effect , less sample demand, simple method of use

Pending Publication Date: 2021-06-04
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chemiluminescence, colloidal gold/colloidal selenium, and enzyme-linked immunoassays can all be used for neutralizing antibody detection, but the inventors found for the first time that when using colloidal gold to detect neutralizing antibodies, the use of traditional control band coating strategies will lead to ...

Method used

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  • Test strip for double-line detection of antibody after novel coronavirus vaccine inoculation
  • Test strip for double-line detection of antibody after novel coronavirus vaccine inoculation
  • Test strip for double-line detection of antibody after novel coronavirus vaccine inoculation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1. A test strip and interpretation method for double-line detection of antibodies after vaccination against the new coronavirus

[0032] A test strip for dual-line detection of antibodies after vaccination against the new coronavirus, such as figure 1 As shown, the test strip includes a base plate 1, a sample pad 2, a binding pad 3, a reaction pad 4 and a water-absorbing pad 5, and the sample pad 2, the binding pad 3, the reaction pad 4 and the water-absorbing pad 5 are sequentially overlapped On the bottom plate 1, the reaction pad 4 is provided with a vaccination reaction detection zone 6, an immune efficacy detection zone 7 and a first control zone 8, and the vaccination reaction detection zone 6 is arranged at one end close to the bonding pad 3 , the first control band 8 is arranged near one end of the water-absorbent pad 5, and the immune efficacy detection band 7 is arranged between the vaccination reaction detection band 6 and the first control band 8;...

Embodiment 2

[0035] Embodiment 2. A test strip and interpretation method for detecting antibodies after vaccination with a new coronavirus vaccine with double test strips and single detection line

[0036] A test strip with double test strips and single detection line for detecting antibodies after vaccination against the new coronavirus, such as figure 2 As shown, it is divided into two test strips, including base plate 1, sample pad 2, binding pad 3, reaction pad 4 and water-absorbing pad 5, the sample pad 2, binding pad 3, reaction pad 4 and water-absorbing pad 5 Overlapped on the base plate 1 in turn, one of the reaction pads 4 of the test strip is provided with a vaccination reaction detection zone 6 and a first control zone 8, and the reaction pad 4 of the other test strip is provided with an immune efficacy detection zone 7 and a second control strip 9. The connecting length between the sample pad 2 and the binding pad 3 is 2 mm, the connecting length between the bonding pad 3 and...

Embodiment 3

[0038] Example 3. Test strips and interpretation methods for two-way detection of antibodies after vaccination against the new coronavirus

[0039] A test strip for two-way detection of antibodies after COVID-19 vaccination, such as image 3 As shown, the test strip includes a sample pad 2, a binding pad 3, a reaction pad 4 and a water-absorbing pad 5, and the sample pad 2 is arranged in the middle of the bottom plate, and the binding pad 3, the reaction pad 4 and the water-absorbing pad 5 Overlapped on the bottom plate in turn, the reaction pads 4 on both sides are provided with a vaccination reaction detection zone 6 and a first control zone 8 on one side, and an immune efficacy detection zone 7 and a second control zone 9 on the other side. The sample pad 2 is a common sample pad, and the connection length between it and the binding pad 3 is 2 mm, the connection length between the combination pad 3 and the reaction pad 4 is 2 mm, and the connection length between the reacti...

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Abstract

The invention discloses a test strip for detecting novel coronavirus vaccination antibodies, which comprises a bottom plate, a sample pad, a combination pad, a reaction pad and a water absorption pad, the sample pad, the combination pad, the reaction pad and the water absorption pad are sequentially overlapped on the bottom plate, the reaction pad is provided with a control band and two detection bands, one of the detection bands is used for detecting whether an organism generates an immune reaction after the novel coronavirus vaccine is inoculated and generating a corresponding antibody; and the other detection band is used for detecting whether the neutralizing antibody generated by the body can reach a certain titer or not to form a protective effect. The test strip is good in sensitivity, good in detection performance, low in cost and simple in use method, and can be used for rapidly, simply and conveniently detecting the effect of the novel coronavirus vaccine after inoculation without professional technicians and professional equipment in multiple scenes such as hospitals, clinics and even at home; the sample demand is low; the effective vaccination rate of the vaccine can be improved, infection caused by poor vaccination effect is prevented, and the vaccine has a good clinical application prospect.

Description

technical field [0001] The invention relates to the technical field of rapid immunochromatographic detection, in particular to a test strip for double-line detection of antibodies after vaccination against the new coronavirus. Background technique [0002] The new type of coronavirus, namely severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the SARS coronavirus in 2003 and the MERS coronavirus in 2012 belong to the genus β of the Coronaviridae family. The virus is also listed by the World Health Organization as the seventh coronavirus to infect people. After the virus is infected, the incubation period is 7-14 days. After the onset, it is accompanied by pneumonia. The common symptoms are fever, cough and myalgia or fatigue; the less common symptoms are sputum, headache, hemoptysis, diarrhea, and dyspnea. The symptoms are similar to those of the common cold, and if not diagnosed and treated in time, there will be difficulty breathing and eventually death. SARS-C...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/569G01N33/58G01N33/558
CPCG01N33/6854G01N33/56983G01N33/585G01N33/558G01N2333/165G01N2469/20
Inventor 王志增张海龙胡航展马晶晶吴梦丽郑植陈春霞张利杰王耀辉魏寅祥马远方
Owner HENAN UNIVERSITY
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