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Oral cavity acid etching agent as well as preparation method and application thereof

An oral cavity and acid etching technology, applied in dental preparations, pharmaceutical formulations, active ingredients of anhydride/acid/halide, etc., can solve problems such as patients’ inability to open their mouths for a long time, time limit for action, and large biological toxicity

Pending Publication Date: 2021-06-08
南昌大学附属口腔医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although glutaraldehyde has good cross-linking reaction characteristics, its effective time (high concentration requires at least 30s or more reaction time) is still limited for practical clinical application (due to the clinical diagnosis and treatment process, the patient cannot open it for a long time). mouth for doctors to perform diagnosis and treatment operations), and its high biological toxicity is also a defect that cannot be ignored in clinical applications

Method used

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  • Oral cavity acid etching agent as well as preparation method and application thereof
  • Oral cavity acid etching agent as well as preparation method and application thereof
  • Oral cavity acid etching agent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A kind of mouth acid etchant, in 100 grams, its specific component content is as follows:

[0038] Theaflavins 3g

[0039] Glycolic acid 35g

[0040] Ascorbic acid 0.01g

[0041] Carboxymethylcellulose 0.01g

[0042] Sodium dihydrogen phosphate dihydrate 0.1g

[0043] Sodium alkylbenzene sulfonate 0.01g

[0044] Sodium carboxymethylcellulose 0.01g

[0045] Water 55.85g

[0046] Preparation:

[0047] S1. Weigh 3g theaflavin, 35g glycolic acid, 0.01g ascorbic acid, 0.01g zinc citrate, 0.1g sodium dihydrogen phosphate dihydrate, 0.01g sodium alkylbenzenesulfonate, 0.01g sodium carboxymethylcellulose, 55.85g deionized water, set aside;

[0048] S2. Add the glycolic acid and antioxidant weighed in S1 into deionized water and dissolve to obtain a mixed solution;

[0049] S3. Add theaflavin, zinc citrate, sodium dihydrogen phosphate dihydrate, surfactant, and deflocculant to the above mixed solution, stir for 30-60 minutes, and fill it to obtain the mouth acid etchant...

Embodiment 2

[0052] A kind of mouth acid etchant, in 100 grams, its specific component content is as follows:

[0053] Theaflavin-3-monogallate 5g

[0054] Glycolic acid 30g

[0055] Alpha-tocopherol 0.1g

[0056] Carboxymethylcellulose 0.1g

[0057] Sodium dihydrogen phosphate dihydrate 1g

[0058] Sodium alkylbenzene sulfonate 0.1g

[0059] Sodium carboxymethylcellulose 0.1g

[0060] Water 58.6g

[0061] Preparation:

[0062] S1. Weigh 5g theaflavin-3-monogallate, 30g glycolic acid, 0.1g ascorbic acid, 0.1g zinc citrate, 1g sodium dihydrogen phosphate dihydrate, 0.1g sodium alkylbenzenesulfonate, 0.1g carboxylate Sodium methylcellulose, 58.6g deionized water, for subsequent use;

[0063] S2. Add the glycolic acid and antioxidant weighed in S1 into deionized water and dissolve to obtain a mixed solution;

[0064] S3. Add theaflavin, zinc citrate, sodium dihydrogen phosphate dihydrate, surfactant, and deflocculant to the mixed solution, stir for 30-60 minutes, and fill it to obtai...

Embodiment 3

[0067] A kind of mouth acid etchant, in 100 grams, its specific component content is as follows:

[0068] Theaflavin-3'-monogallate 6g

[0069] Glycolic acid 38g

[0070] Ascorbic acid 0.1g

[0071] Hydroxypropyl methylcellulose 0.1g

[0072] Sodium dihydrogen phosphate dihydrate 1g

[0073] Sodium alkylbenzene sulfonate 0.1g

[0074] N-Dodecylmethylamine 0.1g

[0075] Water 65.6g

[0076] Preparation:

[0077] S1. Weigh 6g theaflavin-3'-monogallate, 38g glycolic acid, 0.1g ascorbic acid, 0.1g zinc citrate, 1g sodium dihydrogen phosphate dihydrate, 0.1g sodium alkylbenzenesulfonate, 0.1g Sodium carboxymethylcellulose, 65.6g deionized water, for subsequent use;

[0078] S2. Add the glycolic acid and antioxidant weighed in S1 into deionized water and dissolve to obtain a mixed solution;

[0079] S3. Add theaflavin, zinc citrate, sodium dihydrogen phosphate dihydrate, surfactant, and deflocculant to the mixed solution, stir for 30-60 minutes, and fill it to obtain the mo...

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PUM

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Abstract

The invention belongs to the technical field of oral cavity bonding, and particularly relates to an oral cavity acid etching agent and a preparation method and application thereof. The oral cavity acid etching agent comprises theaflavin and glycolic acid. According to the oral cavity acid etching agent provided by the invention, the theaflavin is added, so that the strength of demineralized dentin collagen fibers is enhanced, the MMPs activity is inhibited, the process of caries is blocked, and meanwhile, the durability of a dental resin filling body is improved.

Description

technical field [0001] The invention belongs to the technical field of oral cavity bonding, and in particular relates to an oral acid etchant and a preparation method and application thereof. Background technique [0002] Dental caries, commonly known as caries and tooth decay, is the main common and frequently-occurring disease of the oral cavity, and it is also one of the most common human diseases. The World Health Organization has listed it as one of the three major human diseases for prevention and treatment, along with cancer and cardiovascular diseases. Dental caries is a progressive lesion of tooth hard tissue caused by a combination of factors in the oral cavity. It is manifested in the demineralization of inorganic matter and the decomposition of organic matter. With the development of the disease, it changes from color change to the formation of substantial lesions. Secondary pulpitis and periapical periodontitis can even cause alveolar bone and jaw inflammation. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61K31/19A61P1/02A61K6/60A61K6/69
CPCA61K31/353A61K31/19A61P1/02A61K6/69A61K6/60
Inventor 郭菁杨茗淇花琪张锦胜
Owner 南昌大学附属口腔医院
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