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Oral care solution based on inhibition of microbial quorum sensing and preparation method of oral care solution

An oral care solution and a technology of inhibiting microorganisms, which is applied in the field of oral care, can solve problems such as raw material entrance stimulation, bitter taste, interference with the human endocrine system, and oral micro-ecological imbalance, so as to reduce oral candidiasis, improve oral microbial environment, Comfortable and soft taste

Active Publication Date: 2021-06-11
杭州伊瑟奇生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The abuse of traditional fungicides (chlorhexidine, triclosan, quaternary ammonium salt fungicides such as cetyl ammonium pyridinium chloride) will cause oral microecological imbalance, aggravate tooth aging and cause dental caries, gingivitis and periodontitis The increase of drug resistance will lead to potential risks to the human body and interfere with the human endocrine system. At the same time, the entrance of raw materials will stimulate the taste and make the taste bitter, which is not degradable

Method used

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  • Oral care solution based on inhibition of microbial quorum sensing and preparation method of oral care solution
  • Oral care solution based on inhibition of microbial quorum sensing and preparation method of oral care solution
  • Oral care solution based on inhibition of microbial quorum sensing and preparation method of oral care solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] This example provides a preparation method of an oral care solution based on inhibiting microbial quorum sensing: take 1.5g of Solidago japonica extract, 1g of rhamnolipid, 0.5g of bioactive hyaluronic acid fragments, 0.3g of toutol, 0.5g Schisandra extract, 0.5g honeysuckle extract, 0.5g tea extract, 0.1g trans-farnesol, 10g erythritol, 1g inositol, 0.5g gluconolactone, 0.1g sodium benzoate, mix well, Add water and titrate to 100 g to obtain the oral care solution.

Embodiment 2

[0042] This example provides an oral care solution based on inhibiting quorum sensing of microorganisms, prepared by the method provided in Example 1, including the following components: 1.5% of Solidago japonica extract, 1% of rhamnolipid, and biologically active hyaluronic acid Fragment 0.5%, Totarol 0.3%, Schisandra Extract 0.5%, Honeysuckle Extract 0.5%, Tea Extract 0.5%, Trans-Farnesol 0.1%, Erythritol 10%, Inositol 1%, Glucose Acid lactone 0.5%, sodium benzoate 0.1%, the balance is water.

[0043] see Figure 5 , apply the plaque revealing agent on the surface of the teeth, and you can see that the dark part is the place where the plaque adheres. After rinsing the mouth with the care solution provided in this embodiment for 30 seconds, re-testing shows that the dental plaque is obviously removed and the antibacterial effect is remarkable.

Embodiment 3

[0045] This embodiment provides an oral care solution based on the inhibition of microbial quorum sensing, which includes the following components according to the mass fraction: 3% of Solidago japonica extract, 2% of rhamnolipid, 1% of bioactive hyaluronic acid fragments, and totarol 0.5%, Schisandra Extract 1%, Honeysuckle Extract 1%, Tea Extract 1%, Trans-Farnesol 0.2%, Erythritol 20%, Inositol 2%, Gluconolactone 1%, Benzene Sodium formate 0.3%, the balance is water.

[0046] see Figure 6-7 , using Candida albicans to carry out bacteriostasis test on the oral care solution provided in this embodiment, the control group is normal saline, and other experimental conditions are the same. Figure 6 It is a microscope picture obtained after the mixed culture of physiological saline and Candida albicans, and a large number of hyphae can be seen. Figure 7 The micrograph obtained after the mixed culture of the oral care solution provided by the present embodiment and Candida alb...

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Abstract

The invention discloses an oral care solution based on inhibition of microbial quorum sensing and a preparation method of the oral care solution. The oral care solution comprises the following components in percentage by mass: 0.1-3% of a solidago decurrens extract, 0.1-2% of rhamnolipid, 0.1-1% of a schisandra chinensis extract, 0.1-1% of a honeysuckle extract, 0.1-1% of a tea leaf extract, 0.01-0.5% of totarol, 0.1-1% of a bioactive hyaluronic acid fragment, 0.05-0.2% of trans-farnesol, 2.5-22% of a sweetening agent, 0.25-1.3% of a preservative and the balance of water. The care solution provided by the invention does not damage eukaryotic cells, achieves the effect of cleaning the oral cavity by inhibiting microbial quorum sensing, and is non-toxic to a human body and free of any drug resistance.

Description

technical field [0001] The invention relates to the technical field of oral care, in particular to an oral care liquid based on inhibiting microbial quorum sensing and a preparation method of the oral care liquid based on inhibiting microbial quorum sensing. Background technique [0002] The oral cavity is the first portal of the human body and the first gateway of the digestive system. It is closely related to the respiratory system and is one of the important ways for pathogenic microorganisms to invade the body. The temperature and humidity in the oral cavity are suitable, and the earliest contact with the flora in the air provides excellent conditions for the growth and reproduction of microorganisms. Microorganisms grow in the saliva matrix and form specialized biofilms on soft and hard surfaces. [0003] The dynamic balance between host (saliva, healthy diet, oral hygiene) and biofilm limits microbial growth and creates a common inhibitory effect on opportunistic path...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/60A61K8/73A61K8/34A61Q11/00A61Q17/00A61P1/02A61P31/10A61P31/02
CPCA61K8/9789A61K8/602A61K8/735A61K8/342A61K8/347A61Q11/00A61Q17/005A61P1/02A61P31/10A61P31/02Y02A50/30
Inventor 朱国君罗晓丹邢辉
Owner 杭州伊瑟奇生物科技有限公司
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