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Composition for promoting skin regeneration and hair growth, containing apigenin

A technology for skin regeneration and hair growth, which can be used in medical preparations containing active ingredients, skin diseases, drug combinations, etc. The effect of cell differentiation

Pending Publication Date: 2021-06-22
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Thus, although there has been continuous technical development of products related to skin regeneration or hair loss using apigenin, consumer satisfaction with its efficacy is still at a low level

Method used

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  • Composition for promoting skin regeneration and hair growth, containing apigenin
  • Composition for promoting skin regeneration and hair growth, containing apigenin
  • Composition for promoting skin regeneration and hair growth, containing apigenin

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0067] Preparation Example 1: Preparation of Apigenin

[0068] Large thistle (circium japonicum) is harvested from the mountainous area of ​​Chungbuk, Korea and dried for use. Purchased from Gyeongdong Market (Seoul, Korea) and used after drying. Add 95% alcohol to dry thistle (circium japonium) for extraction, and concentrate through a vacuum concentration device to obtain a crude alcohol extract.

[0069] The alcohol crude extract was dissolved in distilled water and ethyl acetate, mixed with a ratio of 1:1 (v / v), and the distribution between different phases was repeated 3 times, and the ethyl acetate extract was decompressed, Concentrate and dry.

[0070] Carry out silica gel flash column chromatography (solvent meter: chloroform / acetic acid acetic acid=2:1) ​​to described dry thing, after depressurizing and drying active component again, dissolve in a small amount of methanol in a saturated state, use microporous filtration Filter (0.45nm), through high-performance ana...

preparation example 2

[0071] Preparation Example 2: Preparation of Caffeine

[0072] Caffeine was purchased from Sigma Chemicals (St. Louis, MO, USA).

preparation example 3

[0073] Preparation Example 3: Preparation of Ginseng Extract

[0074] After pulverizing 1 kg of dried white ginseng with a mixer, add 5 L of purified water, stir and extract with warm water at 38°C to 42°C for 24 hours, and deposit at 15°C for 1 day. Afterwards, filter through a filter cloth and centrifuge to separate the residue and filtrate, and concentrate the separated filtrate under reduced pressure to obtain 270 g of its extract.

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PUM

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Abstract

The present invention relates to a composition for promoting skin regeneration and hair growth, containing apigenin. More specifically, the composition for promoting skin regeneration and hair growth promotes cell differentiation through Wnt / beta-catenin signaling, thereby exhibiting effects of promoting skin regeneration and hair growth.

Description

technical field [0001] This application claims the benefit of priority based on Korean Patent Application No. 10-2018-0140423 filed on November 15, 2018, and all the contents disclosed in the documents of this Korean Patent Application are incorporated as a part of this specification . [0002] The present invention relates to a composition for promoting skin regeneration and hair growth containing apigenin. Background technique [0003] Skin (skin) exists in the outermost layer of the human body and directly contacts the external environment, so it protects the human body from external damage and plays a role in preventing excessive loss of water and heat in the body. The skin is composed of three layers: epidermis, dermis, and subcutaneous tissue. Most of the outermost epidermis is composed of keratinocytes. Keratinocytes in the epidermis proliferate, move, and differentiate from the base layer. It forms keratin to protect the skin, and produces various cytokines to part...

Claims

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Application Information

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IPC IPC(8): A61K8/49A61K8/9789A61Q19/00A61Q7/00A23L33/10A23L33/105A61K31/352A61K31/522A61K36/258
CPCA23L33/105A61P17/00A61K31/522A61K8/9789A61Q19/00A61Q7/00A23L33/10A61K36/82A61K8/49A61K31/352A61K36/258A61K8/498A61K8/4953A61P17/14A61K2300/00
Inventor 辛承炫金秀娜朴元锡
Owner AMOREPACIFIC CORP
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