Artificial blood vessel stent with biological activity as well as preparation method and application of artificial blood vessel stent

Abstract

The invention relates to an artificial blood vessel stent with biological activity as well as a preparation method and an application thereof. Specifically, the artificial blood vessel stent provided by the invention is of a multi-layer structure comprising an inner layer, an outer layer, a first middle layer and a second middle layer. Meanwhile, the artificial blood vessel stent provided by the invention can be used for preparing a blood vessel repair product or a blood vessel repair animal model. The various cells in the artificial blood vessel provided by the invention are uniformly distributed, good intercellular connection performance is reserved among the various cells, and the artificial blood vessel has good mechanical performance; meanwhile, compared with a real blood vessel, the artificial blood vessel stent has a similar anatomical structure, good biocompatibility and excellent mechanical strength, raw materials are easy to obtain, the preparation method is simple and easy to implement, and mass production can be achieved. The artificial blood vessel stent provided by the invention has very important clinical application basic research value and social and economic benefits.

Description

technical field [0001] The invention relates to a biologically active artificial blood vessel stent, a preparation method and application thereof, and belongs to the field of medical implant materials. Background technique [0002] Cerebrovascular disease has become the disease with the highest disability and mortality rate in human beings. Extracranial and extracranial vascular bypass surgery is one of the important surgical treatments for moyamoya disease, intracranial complex aneurysm and ischemic cerebrovascular disease. At present, the blood vessels commonly used in intracranial and intracranial vascular bypass surgery are mainly autologous blood vessels, allogeneic blood vessels and traditional artificial blood vessels. However, no matter whether it is an autologous blood vessel, an allogeneic blood vessel, or a traditional artificial blood vessel, there are certain defects. [0003] On the one hand, autologous blood vessels are obtained by intercepting the blood vess...

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Problems solved by technology

However, the construction process of this cross-scale blood vessel is complicated, and the mechanical strength is low, and the lining cells are unevenly distributed.

[0005] At the same time, some researchers used four-channel coaxial technology to fabricate solid multi-level structures ( figure 1 ), but its solid structure cannot be used for blood transport and vascular grafting (He J, Shao J, Li X, et al.Bioprinting of coaxialmulticellular structures for a 3D co-culture model[J].Bioprinting,2018,11); further Yes, there are also researchers using three-channel coaxial technology to make a hollow multi-layered vascular structure, the innermost layer is hollow, and the outer two layers are injected with two kinds of bio-inks of printed cell mixed support materials ( figure 2 ), but this method cannot achieve the effect of separating the printed cells from the non-cellular support material, which is likely to cause poor growth and reproduction of cells in bioactive blood vessels (Qingmeng P, Sushila M, Xiang Y, et al. Digitally Tunable Microfluidic Bioprinting of Multilayered Cannular Tissues[J].Advanced Materials,2018:1706913)

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