3D printing ginkgo biloba extract tablet and preparation method thereof

A ginkgo ketone ester tablet, 3D printing technology, applied in the direction of medical raw materials derived from Ginkgo biloba, pill delivery, pharmaceutical formulations, etc., can solve the problem of inability to meet the needs of patients with chronic diseases, focus on immediate release preparations, poor flexibility and selectivity of preparations, etc. problems, to achieve the effects of flexible release, high drug loading, and low dosage of excipients

Active Publication Date: 2021-07-09
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commercially available ginkgo tablet preparations are prepared in an integrated manner, and the preparation flexibility and selectivity are poor
The latest research has used 3D printing technology to improve the drug preparation, but it only focuses on immediate release preparations, which cannot meet the needs of patients with chronic diseases

Method used

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  • 3D printing ginkgo biloba extract tablet and preparation method thereof
  • 3D printing ginkgo biloba extract tablet and preparation method thereof
  • 3D printing ginkgo biloba extract tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 The printing path is the preparation of Z-shaped 3D printing ginkgo ketone ester tablet

[0030] 2.0g ginkgo ketone ester extract and 2.1g croscarmellose sodium powder (viscosity is 3000mpa.s) are mixed and added to molten 3.1g polyethylene glycol (molecular weight is 3500) feed liquid, and Stir evenly, add it to the printer barrel immediately, and fix the barrel position. According to the pre-set parameters: path: Z-shaped, tablet diameter: 3mm, tablet thickness: 1.5mm, layer height: 0.2mm, gap 0.5mm, needle diameter 0.2mm, printing temperature 54°C, printing speed 8mm / s, the gas pressure is 100psi for printing. After printing, place the tablet in a desiccator to dry.

Embodiment 2

[0031] Embodiment 2 The printing path is the preparation of the 3D printing ginkgo ketone ester tablet of concentric circle type

[0032] 1.6g ginkgo ketone ester extract and 1.7g croscarmellose sodium powder (viscosity is 5000mpa.s) are mixed and added to molten 4.0g polyethylene glycol (molecular weight is 6000) feed liquid, and Stir evenly, add it to the printer barrel immediately, and fix the barrel position. According to the pre-set parameters: path: concentric circle, tablet diameter: 8mm, tablet thickness: 3mm, layer height: 0.3mm, gap 0.6mm, needle diameter 0.4mm, printing temperature 59°C, printing speed 6mm / s, the gas pressure is 110psi for printing. After printing, place the tablet in a desiccator to dry.

Embodiment 3

[0033] Example 3 The printing path is the preparation of grid-type 3D printing ginkgo ketone ester tablet

[0034] 3.4g ginkgo ketone ester extract and 3.0g croscarmellose sodium powder (viscosity is 4000mpa.s) are mixed and added to molten 3.0g polyethylene glycol (molecular weight is 4000) feed liquid, and Stir evenly, add it to the printer barrel immediately, and fix the barrel position. According to the pre-set parameters: path: grid type, tablet diameter: 13mm, tablet thickness: 6mm, layer height: 0.5mm, gap 0.8mm, needle diameter 0.3mm, printing temperature 50°C, printing speed 12mm / s, the gas pressure is 100psi for printing. After printing, place the tablet in a desiccator to dry. Figure 1-3 SEM images of 3D printed ginkgo ketone ester tablets with Z-shaped, concentric circle and grid-shaped printing paths, respectively. Figure 4 A is the Fourier transform infrared spectrum of the 3D printed ginkgo ketone ester tablet, b is the Fourier transform infrared spectrum ...

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Abstract

The invention provides a 3D printing ginkgo biloba extract tablet. The tablet is prepared from the following components in percentage by weight: 22-36% of a ginkgo biloba extract, 22-34% of croscarmellose sodium and 34-57% of polyethylene glycol. The 3D printing ginkgo biloba extract tablet disclosed by the invention is prepared by adopting a simple fused deposition type 3D forming process, an internal printing path can be conveniently adjusted, and various flexible release requirements of medicines can be met. The dosage of auxiliary materials is small, the drug loading capacity is high, the in-vivo release time is long, and the requirements of chronic cardiovascular and cerebrovascular diseases can be well met.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a 3D printed ginkgo ketone ester tablet and a preparation method thereof. Background technique [0002] Due to the accelerated pace of life, irregular eating habits and other factors, the incidence of cardiovascular and cerebrovascular diseases has increased year by year, and people's awareness of cardiovascular and cerebrovascular disease prevention and treatment has gradually increased. Ginkgo biloba extract is sweet, bitter, damp, flat, heart-guiding, and lung meridian. The curative effect is remarkable in dizziness, coronary heart disease, angina pectoris and other symptoms, so the ginkgo tablet preparation has received extensive attention. Since the incidence of cardiovascular and cerebrovascular diseases tends to be younger, higher requirements are placed on the effectiveness and selectivity of ginkgo tablet preparations. Commercially available ginkgo tablet pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38A61K47/10A61K36/16A61P9/00A61P9/10A61P9/02B33Y70/10B33Y80/00
CPCA61K9/2054A61K9/2031A61K36/16A61P9/00A61P9/10A61P9/02B33Y70/10B33Y80/00
Inventor 王海霞李永圆陈晨李正王苹
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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