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Derivatives of carbocyclic compounds derived from turnip and uses thereof

A compound and derivative technology, applied in the field of redevelopment and utilization of natural plant-derived carbocyclic compounds, can solve problems such as roughness, and achieve the effects of easy process control, improved yield, and improved bioavailability

Active Publication Date: 2021-07-09
西藏甘露藏药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the current way of medicinal use of Manjing extract is relatively rough, and it is necessary to develop Manjing extract and its derivatives in order to achieve more precise and efficient medicinal methods

Method used

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  • Derivatives of carbocyclic compounds derived from turnip and uses thereof
  • Derivatives of carbocyclic compounds derived from turnip and uses thereof
  • Derivatives of carbocyclic compounds derived from turnip and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] Embodiment 1: a kind of dry paste of Manjing:

[0101] Such as image 3 and Figure 4 As shown, the present embodiment prepares a kind of manjing dry cream through the following steps:

[0102] 1) After cleaning, slicing, and drying 6.6kg of mandarin greens, add 63.58L of water to a 500L sandwich pot for the first decoction. The decoction temperature is 180°C and the decoction time is 190min. , stirring at 120r / min every 20min for 1min, filtering through a 100-mesh sieve to obtain medicinal residue Ⅰ and medicinal liquid Ⅰ; take medicinal residue Ⅰ and add 57.4L of water to a sandwich pot with a capacity of 500L, and decoct for the second time at a temperature of 180°C , decocting time 120min, stirring at 120r / min every 20min for 1min; filtering through a 100-mesh sieve to obtain medicinal residue II and medicinal liquid II; medicinal residue II wrapped in fine gauze bags and squeezed hard to obtain medicinal residue III and medicinal liquid III Ⅲ is used separately;...

Embodiment 2

[0119] Example 2: Carbocyclic compounds derived from Brassica chinensis:

[0120] In this embodiment, the carbocyclic compound derived from turmeric shown in formula (2) is prepared from the dried turmeric paste obtained in Example 1, and the specific steps include:

[0121] A, get the manjing dry extract of embodiment 1, add 88vol% ethanol solution of 16 times of weight, contain 1.0vol% oxalic acid in the ethanol solution, be heated to 50 ℃ of reflux extractions 3 times, each 1.5h, combine extracting solution, reduce After recovering under pressure until there is no alcohol smell, add water to dilute, filter through medium-speed filter paper, and concentrate the filtrate to 1 / 10 volume at 50°C to obtain an extract;

[0122] B. The extract is decolorized twice with petroleum ether, the lower layer liquid is extracted twice with ethyl acetate, and the lower layer liquid is taken to obtain a crude extract, which is concentrated under reduced pressure and extracted with ethyl ace...

Embodiment 3

[0129] Example 3: Carbocyclic compounds derived from Brassica chinensis:

[0130] In this example, the carbocyclic compound derived from turmeric shown in the formula (2) of the present application is prepared from the dried turmeric paste obtained in Example 1. The specific steps include:

[0131] A. Take the dried manjing extract of Example 1, add 16 times the weight of 88vol% ethanol solution, heat to 50°C for reflux extraction 3 times, each time for 1.5h, combine the extracts, recover under reduced pressure until there is no alcohol smell, then add water to dilute , filtered through medium-speed filter paper, and the filtrate was concentrated to 1 / 10 volume at 50°C to obtain an extract;

[0132] B, with step B in embodiment 2;

[0133] C, with step C in embodiment 2

[0134] D, with step D in embodiment 2.

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Abstract

The invention relates to the technical field of natural plant-derived carbocyclic compounds, in particular to a derivative of a carbocyclic compound derived from turnip and application of the derivative, the derivative has a structural formula shown in the formula (1), and the preparation process mainly comprises the following steps: decocting turnip, concentrating and drying to obtain turnip dry paste; carrying out alcohol extraction on a turnip dry extract, extracting the turnip dry extract with an ethyl acetate and ethyl acetate-methanol mixed solution, carrying out silica gel column chromatography separation and semi-preparative liquid chromatography separation to obtain a carbocyclic compound derived from turnip, and reacting the carbocyclic compound with 3-bromomethyl-oxetane to obtain the derivative disclosed by the invention. The preparation method is simple, the process is easy to control, and the target product yield is high. The derivative provided by the invention has an excellent effect of inhibiting pancreatic lipase activity so as to achieve the purpose of losing weight without dieting, also has an excellent effect of resisting pulmonary fibrosis, and can reduce the degree of pulmonary fibrosis induced by BLM; therefore, the medical application value of the carbocyclic compound derived from turnip and the derivative thereof is expanded.

Description

technical field [0001] The invention relates to the technical field of redevelopment and utilization of natural plant source carbocyclic compounds, in particular to the derivatives and applications of carbocyclic compounds derived from Brassica chinensis. Background technique [0002] Manjing is the dried root and seed of Brassica rapa L. in the family Brassicaceae. It is harvested in autumn when the root and seed are mature. It is sweet in taste and warm in nature. , cure Bacon's disease, dragon's disease, weak body, poisoning. The name of the Tibetan medicine is "Niuma" ("Four Medical Codes"), and the common names in Tibet are "Manjing" and "Yuangen" (or "Xianggen", "Yuangen", etc.). In the Uyghurs, the turnip is also known as "Qiamagu", and it only refers to the root of the turnip plant. Both Tibetans and Uyghurs have a long history of the same source of medicine and food. Uyghur medicine believes that turnips are sweet, pungent, bitter, and warm in nature. It is used ...

Claims

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Application Information

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IPC IPC(8): C07J63/00A61P11/00A61P3/04A61K31/58
CPCC07J63/008A61P11/00A61P3/04
Inventor 周凤旦增洛布平措南加左谷白玛
Owner 西藏甘露藏药股份有限公司
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