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Ultrahigh-voltage nanosecond pulsed electric field controllable extracorporeal circulation erythrocyte electroporation treatment device

A nanosecond pulse, treatment device technology, applied in the medical field, can solve problems such as inability to remove uremic toxins, and achieve the effects of achieving treatment efficiency, reducing economic burden, and increasing safety

Pending Publication Date: 2021-07-16
北京大学国际医院
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  • Abstract
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Problems solved by technology

Red blood cells in the blood are also important carriers of uremic toxins, but none of the above conventional treatments can remove uremic toxins in red blood cells

Method used

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  • Ultrahigh-voltage nanosecond pulsed electric field controllable extracorporeal circulation erythrocyte electroporation treatment device
  • Ultrahigh-voltage nanosecond pulsed electric field controllable extracorporeal circulation erythrocyte electroporation treatment device
  • Ultrahigh-voltage nanosecond pulsed electric field controllable extracorporeal circulation erythrocyte electroporation treatment device

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Embodiment Construction

[0029] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the drawings in the embodiments of the present invention.

[0030] Such as Figure 1-3 As shown, the present invention provides a technical solution: ultra-high voltage nanosecond pulse electric field controllable extracorporeal circulation erythrocyte electroporation treatment device, including a four-way tube 100 that can be connected to extracorporeal circulation, and a high-voltage electrode for pulsed high-voltage treatment field 200. Square-wave high-voltage output device 300 with adjustable ultra-high voltage nanosecond pulse, high-voltage cable 400, electroporation treatment field 500 for reversible and controllable electroporation of extracorporeal circulation red blood cells, and insulating protective sheath for electrode cable connection 600;

[0031] The four-way pipe (100) is made of polyvinyl chloride, and the four-way p...

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Abstract

The invention discloses an ultrahigh-voltage nanosecond pulsed electric field controllable extracorporeal circulation erythrocyte electroporation treatment device. The device comprises a four-way pipe capable of being connected with extracorporeal circulation, a high-voltage electrode used for a pulse high-voltage treatment field, a square-wave high-voltage output device capable of adjusting ultrahigh-voltage nanosecond pulses, a high-voltage cable, an electroporation treatment field capable of generating reversible and controllable electroporation on extracorporeal circulation red blood cells, and an insulating protective sleeve used at the joint of the electrode and the cable, the four-way pipe is made of a polyvinyl chloride material, the four-way pipe comprises two groups of transverse pipes, two groups of longitudinal pipes and a converging part, and the transverse pipes and the longitudinal pipes are connected to four end surfaces of the converging part. According to the invention, the release of pathogenic substances carried by red blood cells can be promoted without affecting the conventional blood purification treatment, the treatment effect is greatly improved through the substance removal effect, and the electric field in the treatment field is regulated and controlled through the electrodes, so that the continuous treatment is carried out on blood passing through the treatment field.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to an ultrahigh voltage nanosecond pulse electric field controllable extracorporeal circulation red blood cell electroporation treatment device. Background technique [0002] The components of blood include plasma and formed components, and the formed components include red blood cells, white blood cells, and platelets. The volume ratio of red blood cells in normal blood can reach 37%-50%. In addition to carrying and transporting oxygen and carbon dioxide, red blood cells also store and transport other metabolites. Red blood cells can flow throughout the body with the blood and are extremely important material transport carriers for the body. At present, the most widely used treatment for uremia patients at home and abroad is blood purification, including hemodialysis, hemofiltration, hemodiafiltration, hemoperfusion and many other treatment methods, but these treatments can only ...

Claims

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Application Information

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IPC IPC(8): A61M1/36A61N1/00
CPCA61M1/36A61N1/00
Inventor 张东亮张策杨成宇柳竹青罗莉
Owner 北京大学国际医院
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