Large-flux cell sound sorting chip

Abstract

The invention discloses a large-flux cell sound sorting chip, which comprises a piezoelectric substrate, an interdigital transducer, a sorting flow channel substrate and a sorting flow channel, the interdigital transducer is sputtered on the piezoelectric substrate, the sorting flow channel is bonded on the sorting flow channel substrate, and the piezoelectric substrate, the interdigital transducer and the sorting flow channel are sequentially arranged from bottom to top. The piezoelectric substrate, the interdigital transducer, the sorting flow channel substrate and the sorting flow channel are arranged in sequence. The interdigital transducer is arc-shaped or arrowhead-shaped, an arc-shaped interdigital transducer is a focusing type interdigital transducer, an arrowhead-shaped interdigital transducer is a focusing type interdigital transducer. The sound sorting chip has the beneficial effects that the characteristic size of the sorting flow channel can be increased, so that the sorting flux and the sound streaming effect can be improved. The substrate of the sorting flow channel is an insulating layer substrate with a convex-concave structure or an wettability optimized substrate. The regularized insulating layer substrate with the convex-concave structure or the wettability optimization substrate increases the movement difference of particles in the liquid in the separation flow channel, and the separation efficiency and the separation purity are improved.

Description

technical field [0001] The invention relates to a sorting chip, in particular to a large-throughput cell acoustic sorting chip. Background technique [0002] At present, with the rapid development of microfluidic technology, the concept of microfluidic chips has begun to play an increasingly important role in the fields of chemistry, medicine, and biology. At present, microfluidic chips have gradually become a mature research field, and microfluidic sorting technology, as one of the important functions of microfluidic chips, has broad application prospects. In fact, sorting methods based on different mechanisms have their own advantages, disadvantages and limitations in terms of sorting throughput, purity, and precision. Acoustic microfluidic devices are powerful tools for manipulating cells at the micron or nanoscale in analytical chemistry and biomedicine using sound waves. Acoustic microfluidic chip has become an ideal platform for basic research due to its characterist...

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a large-throughput acoustic cell sorting chip in order to solve the low-throughput bottleneck problem generally existing in the existing acoustic cell sorting chips

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