A large-throughput cell acoustic sorting chip

Abstract

The invention discloses a large-flux cell acoustic sorting chip, which includes a piezoelectric substrate, an interdigital transducer, a sorting flow channel base and a sorting flow channel, wherein the interdigital transducer is sputtered on the piezoelectric On the substrate, the sorting channel is bonded to the sorting channel base, and the piezoelectric substrate, the interdigital transducer, the sorting channel base and the sorting channel are arranged sequentially from bottom to top. The shape of the IDT is arc-shaped or arrow-shaped, the arc-shaped IDT is a focus-type IDT, and the arrow-shaped IDT is a focus-type IDT beneficial effect: the characteristic size of the sorting channel can be increased, which helps to improve the effect of sorting flux and acoustic flow. The sorting channel substrate is an insulating layer substrate with a convex-concave structure or a wettability-optimized substrate. The regular insulating layer substrate with convex-concave structure or wettability-optimized substrate increases the difference in particle motion in the liquid in the sorting flow channel, and improves the efficiency and purity of sorting.

Description

technical field [0001] The invention relates to a sorting chip, in particular to a large-throughput cell acoustic sorting chip. Background technique [0002] At present, with the rapid development of microfluidic technology, the concept of microfluidic chips has begun to play an increasingly important role in the fields of chemistry, medicine, and biology. At present, microfluidic chips have gradually become a mature research field, and microfluidic sorting technology, as one of the important functions of microfluidic chips, has broad application prospects. In fact, sorting methods based on different mechanisms have their own advantages, disadvantages and limitations in terms of sorting throughput, purity, and precision. Acoustic microfluidic devices are powerful tools for manipulating cells at the micron or nanoscale in analytical chemistry and biomedicine using sound waves. Acoustic microfluidic chip has become an ideal platform for basic research due to its characterist...

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a large-throughput acoustic cell sorting chip in order to solve the low-throughput bottleneck problem generally existing in the existing acoustic cell sorting chips

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