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A large-throughput cell acoustic sorting chip

A high-throughput, sorting technology, applied in laboratory containers, biomass post-processing, specific-purpose bioreactors/fermenters, etc., can solve problems such as low-throughput bottlenecks, reduce energy loss, The effect of avoiding corner effects, improving efficiency and sorting purity

Active Publication Date: 2022-04-08
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a large-throughput acoustic cell sorting chip in order to solve the low-throughput bottleneck problem generally existing in the existing acoustic cell sorting chips

Method used

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  • A large-throughput cell acoustic sorting chip
  • A large-throughput cell acoustic sorting chip
  • A large-throughput cell acoustic sorting chip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The large-throughput cell acoustic sorting chip provided by the present invention includes a piezoelectric substrate 1, an interdigital transducer 2, a sorting channel substrate 3 and a sorting channel 4, wherein the interdigital transducer 2 is sputtered on On the piezoelectric substrate 1, the sorting channel 4 is sputtered on the sorting channel substrate 3, from bottom to top, the piezoelectric substrate 1, the interdigital transducer 2, the sorting channel substrate 3 and the sorting flow channel Lane 4 is set in turn.

[0029] The piezoelectric substrate 1 is made of lithium niobate single crystal material.

[0030] The shape of the interdigital transducer 2 is arc-shaped, and the arc-shaped interdigital transducer 2 is a focusing type interdigital transducer. The central axis of the interdigital transducer 2 and the central axis of the upper sorting channel 4 Correspondingly, the sorting channel base 3 is a sorting channel base 3 with an insulating layer of a co...

Embodiment 2

[0034] The large-throughput cell acoustic sorting chip provided by the present invention includes a piezoelectric substrate 1, an interdigital transducer 2, a sorting channel substrate 3 and a sorting channel 4, wherein the interdigital transducer 2 is sputtered on On the piezoelectric substrate 1, the sorting channel 4 is sputtered on the sorting channel substrate 3, from bottom to top, the piezoelectric substrate 1, the interdigital transducer 2, the sorting channel substrate 3 and the sorting flow channel Lane 4 is set in sequence.

[0035] The piezoelectric substrate 1 is made of lithium niobate single crystal material.

[0036] The shape of the interdigital transducer 2 is arrow-shaped, and the arrow-shaped interdigital transducer 2 is a focusing-type interdigital transducer. The axes are arranged correspondingly, the sorting channel base 3 is a sorting channel base with optimized wettability, and the regional wettability structures on the sorted channel base 3 with opti...

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Abstract

The invention discloses a large-flux cell acoustic sorting chip, which includes a piezoelectric substrate, an interdigital transducer, a sorting flow channel base and a sorting flow channel, wherein the interdigital transducer is sputtered on the piezoelectric On the substrate, the sorting channel is bonded to the sorting channel base, and the piezoelectric substrate, the interdigital transducer, the sorting channel base and the sorting channel are arranged sequentially from bottom to top. The shape of the IDT is arc-shaped or arrow-shaped, the arc-shaped IDT is a focus-type IDT, and the arrow-shaped IDT is a focus-type IDT beneficial effect: the characteristic size of the sorting channel can be increased, which helps to improve the effect of sorting flux and acoustic flow. The sorting channel substrate is an insulating layer substrate with a convex-concave structure or a wettability-optimized substrate. The regular insulating layer substrate with convex-concave structure or wettability-optimized substrate increases the difference in particle motion in the liquid in the sorting flow channel, and improves the efficiency and purity of sorting.

Description

technical field [0001] The invention relates to a sorting chip, in particular to a large-throughput cell acoustic sorting chip. Background technique [0002] At present, with the rapid development of microfluidic technology, the concept of microfluidic chips has begun to play an increasingly important role in the fields of chemistry, medicine, and biology. At present, microfluidic chips have gradually become a mature research field, and microfluidic sorting technology, as one of the important functions of microfluidic chips, has broad application prospects. In fact, sorting methods based on different mechanisms have their own advantages, disadvantages and limitations in terms of sorting throughput, purity, and precision. Acoustic microfluidic devices are powerful tools for manipulating cells at the micron or nanoscale in analytical chemistry and biomedicine using sound waves. Acoustic microfluidic chip has become an ideal platform for basic research due to its characterist...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00C12M1/42C12M1/00
CPCB01L3/502761C12M23/16C12M35/04C12M47/04
Inventor 刘国君李星奇董轮涛刘晓鹏沈望皓王聪慧李新波孙晓东
Owner JILIN UNIV
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